Phytochemical Screening and in vitro evaluation of free radical scavenging activity of Cordia macleodii bark. (HOOK.F. & THOMSON)

Abstract

Antioxidant activity has been assessed by in vitro method for phytochemical fraction of plant, viz. methanolic and butanol extracts of Cordia macleodii bark. This investigation was under taken to evaluate methanolic and butanol extract of Cordia macleodii bark for possible antioxidants potential. The extracts were evaluated for their phenolic content & antioxidant activity. Phenolic content was measured using Folin-ciocalte reagent & was calculated as Gallic acid equivalents. Antiradical activity of both extracts was measured by 1, 1, diphenyl-2, picrylhydrazyl (DPPH) assay & was compared to ascorbic acid and Ferric reducing power (FRAP) of the extract was also evaluated by Oyaizu et al. In the present study three in vitro models were used for evaluate of antioxidant activity. The first two methods were for direct measurement of radical scavenging activity & remaining one method evaluated the reducing power. The present study revealed the Cordia macleodii bark has significant radical scavenging activity.

In Vitro Antioxidant Activity, Total Phenolic Contents and Phytochemical Evaluation From Crude Extracts of an Endangered Plant Cordia Macleodii Hook. F. Thomson

“…The genus Cordia macleodii, an endangered medicinal plant belongs to family Boraginaceae, traditionally known as Dahipalas or Dahiman and it is distributed in moist-dry deciduas forest of central India. It is well known that the leaf and bark extracts of C. macleodii have various pharmaceutical activity such as hepatoprotective, acute toxicity, inflammatory, antioxidant, antibacterial, antifungal, wound healing, antivenom potential activity [10,11]. In addition, screening of preliminary phytochemical analysis of leaf and bark has indicated the presence of several phytochemicals viz tannins, phenols, flavonoids, saponins, alkaloids and glycosides [12,13].…”

Antioxidant Compound Quercetin-3-O-α-L-rhamnoside(1→6)- β-D-glucose (Rutin) isolated from ethyl acetate leaf extracts of Memecylon edule Roxb (Melastamataceae)

“…1 Antioxidants have been reported to prevent oxidative damage caused by free radical, it can interfere with the oxidation process by reacting with free radicals, chelating, catalytic metals and also by acting as oxygen scavengers. 2 Imbalance of free radicals and antioxidant rustled oxidative stress. Hence, certain amounts of exog enous anti-oxidants are constantly required to maintain an adequate level of anti-oxidants in order to balance the ROS in human body.…”

Secondary metabolite credentials and in vitro free radical scavenging activity of Alpinia calcarata

“…Natural antioxidants like flavonoid, phenols, terpenoids, polyphenols, etc., present in medicinal plants are responsible for inhibiting or preventing the deleterious consequences of oxidative stress. 19 In the present work, A. calcarata rhizome was used to analyze its phytochemical constituents and in vitro antioxidant scavenging activity. The results of qualitative phytochemical screening were depicted in Table 1.…”