Phytochemical screening and antioxidant properties of methanolic extract of root of<i>Asparagus racemosus</i>Linn

Behera, Suraj K.

doi:10.1080/10942912.2018.1560310

Cited by 27 publications

(17 citation statements)

References 20 publications

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“…The present study revealed potent inhibition of H 2 O 2 radicals by the extracts in a concentration-dependent manner, with lower IC 50 values obtained from the alcoholic extracts (about 4.7 and 3.2 µg/mL for the MEEI and EEEI extracts, respectively) compared to that from the apolar one (about 18.4 µg/mL). This data is in agreement with that achieved from the methanolic extract from E. compressa (about 2.8 µg/mL) [ 9 ] but considerably lower than that from the root of Asparagus racemosus Linn (about 27.6 µg/mL) [ 33 ]. Superoxide anion radicals are well known initiators of hydrogen peroxide or singlet oxygen in living systems [ 34 ].…”

Section: Discussionsupporting

confidence: 89%

“…By getting an electron from an antioxidant molecule, DPPH • becomes diamagnetic by reduction into hydrazine derivative [ 36 ]. The MEEI extract presented very low IC 50 values (about 0.5 and 0.3 µg/mL for the DPPH • and the • OH scavenging assays, respectively) performing significantly better than ascorbic acid (about 2.6 and 2.3 µg/mL for the DPPH • and the • OH scavenging assays, respectively) and compared to the extracts from E. compressa (about 3.2 and 2.9 µg/mL, respectively) and Asparagus racemosus Linn (about 9.9 and 169.3 µg/mL, respectively) [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

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Preliminary Investigation of the Antioxidant, Anti-Diabetic, and Anti-Inflammatory Activity of Enteromorpha intestinalis Extracts

et al. 2021

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Marine algae are a promising source of potent bioactive agents against oxidative stress, diabetes, and inflammation. However, the possible therapeutic effects of many algal metabolites have not been exploited yet. In this regard, we explored the therapeutic potential of Enteromorpha intestinalis extracts obtained from methanol, ethanol, and hexane, in contrasting oxidative stress. The total phenolic (TPC) and flavonoids (TFC) content were quantified in all extracts, with ethanol yielding the best values (about 60 and 625 mg of gallic acid and rutin equivalents per gram of extract, respectively). Their antioxidant potential was also assessed through DPPH•, hydroxyl radical, hydrogen peroxide, and superoxide anion scavenging assays, showing a concentration-dependent activity which was greater in the extracts from protic and more polar solvents. The α-amylase and α-glucosidase activities were estimated for checking the antidiabetic capacity, with IC50 values of about 3.8 µg/mL for the methanolic extract, almost as low as those obtained with acarbose (about 2.8 and 3.3 µg/mL, respectively). The same extract also showed remarkable anti-inflammatory effect, as determined by hemolysis, protein denaturation, proteinase and lipoxygenase activity assays, with respectable IC50 values (about 11, 4, 6, and 5 µg/mL, respectively), also in comparison to commercially used drugs, such as acetylsalicylic acid.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Preliminary Investigation of the Antioxidant, Anti-Diabetic, and Anti-Inflammatory Activity of Enteromorpha intestinalis Extracts

et al. 2021

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“…Antioxidant activity (IC 50 value) was found to be maximum in late monsoon and minimum in monsoon. It should be recognized that the lowest IC50 value shows the most powerful activity of anti-free radicals 54 . The rabbiteye blueberry leaves collecting in November had the maximum antioxidant capacity 49 .…”

Section: Resultsmentioning

confidence: 99%

Dynamics of bioactive components of the roots of Shatamuli (Asparagus racemosus Willd.) in three different seasons

2021

IJGHC

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Dynamics of bioactive components viz. minerals, alkaloids, flavonoids, polyphenol and antioxidant activities of the roots of Asparagus racemosus Willd. were investigated in three different harvesting seasons within a year. An experiment was framed during February, 2017 to February, 2019 at Natore Kholabaria owshadi village in Bangladesh. The soil of Shatamuli growing sites was found to be clay loam. The highest minerals were measured in monsoon (July-September) and lowest in late monsoon (October-December). Whilst the maximum alkaloids and flavonoids content were estimated in the root extract of early monsoon (April-June) and the minimum in late monsoon (October-December) and monsoon (July-September). Furthermore, the highest polyphenol and antioxidant activity were determined in the root extract of late monsoon (October-December) and the lowest in monsoon (July-September) and early monsoon (April-June). The study concludes that monsoon (July-September) is the perfect time for the accumulation of minerals in the root of Asparagus and early monsoon (April-June) is for alkaloids and flavonoids synthesis and late monsoon (October-December) is suitable for collecting roots of Shatamuli to obtain highest amount of polyphenol and antioxidant activity (IC50 value) for medicinal use.

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“…Phytochemical analyses for major constituents were carried out based on the procedures of Harborne, 18 Fadeyi et al 19 and Tiwari. 20 The phytochemicals assessed were: Alkaloids, flavonoids, glycosides, tannins, saponins, triterpenoids compounds, phenols and steroids, and oxalate.…”

Section: Methodsmentioning

confidence: 99%

Reno-Hepatoprotective and Antidiabetic Properties of Methanol Leaf Extract of Laportea Aestuans in Wistar Rats

Adetunji

Olugbami

Adegoke

et al. 2021

J Evid Based Complementary Altern Med

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Toxicities due to exposure to arsenic-contaminated water and the occurrence of diabetes mellitus are major health concerns. Treatment of these concerns using therapeutic measures have recorded limited success. Traditionally, Laportea aestuans (LA) has been used in managing various diseases. Hence, we investigated the reno-hepatoprotective/antidiabetic potentials of methanol leaf extract of LA (MeLELA) in male Wistar rats. Thirty rats (100-150 g) were equally distributed into 6 groups: Group I (vehicle-treated); group II received 2.5 mg/kg sodium arsenite (SA) thrice a week for 2 weeks; group III received streptozotocin (STZ, 50 mg/kg once); group IV received 200 mg/kg LA daily for 14 days; group V received SA and LA; group VI received STZ and LA. Sodium arsenite and STZ induced reno-hepatotoxicity and diabetes, respectively. Phytochemical screening, biomarkers/enzyme activities, blood glucose levels, micronucleus assay, kidney, liver and pancreas histologies were determined according to standard procedures. Alkaloids, carotenoids and flavonoids were present in abundance. Both SA-and STZ-treated groups recorded significant (p < 0.05) reductions in serum protein concentrations, while co-treatment with LA significantly restored the levels. The SA-induced significant increase in creatinine/urea levels were significantly reduced by LA. Co-treatment of each of SA-and STZ-treated groups, respectively, with LA significantly decreased the elevated serum alanine and aspartate aminotransferases’ activities. Increased blood glucose level in diabetic group was remarkably lowered by LA. Also, the SA-induced frequency of micronucleated polychromatic erythrocytes was significantly ameliorated by LA. Conclusively, LA is protective against SA-induced toxicity and STZ-induced diabetes in Wistar rats.

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Phytochemical screening and antioxidant properties of methanolic extract of root ofAsparagus racemosusLinn

Cited by 27 publications

References 20 publications

Preliminary Investigation of the Antioxidant, Anti-Diabetic, and Anti-Inflammatory Activity of Enteromorpha intestinalis Extracts

Preliminary Investigation of the Antioxidant, Anti-Diabetic, and Anti-Inflammatory Activity of Enteromorpha intestinalis Extracts

Dynamics of bioactive components of the roots of Shatamuli (Asparagus racemosus Willd.) in three different seasons

Reno-Hepatoprotective and Antidiabetic Properties of Methanol Leaf Extract of Laportea Aestuans in Wistar Rats

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