Phytochemical screening and antimicrobial activities studies of<i>Acacia nilotica</i>fruit cover

Abdalla, Abdelhamed A.; Mustafa, Mujahed I.; Makhawi, Abdelrafie M.

doi:10.1101/2020.02.11.943456

Cited by 12 publications

(23 citation statements)

References 13 publications

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“…The yield is presented in table 1. The percentage of yield is relatively close to the one earlier reported 20 .…”

Section: Collection Of Plant Materials Phytochemical Screening and Gc-ms Analysis Of Acacia Nilotica Podsupporting

confidence: 89%

“…The aqueous extracts of Acacia nilotica Pod yielded The results in this regard agree with the work of 21 for aqueous extracts. 20 also identified Glycosides, Flavonoid, Terenoid, Saponins, and Tannins in both H2O and Methanolic extracts.…”

Section: Collection Of Plant Materials Phytochemical Screening and Gc-ms Analysis Of Acacia Nilotica Podmentioning

confidence: 85%

“…Flavonoids are found in food, responsible for taste, colour, and phenolic compounds therapeutic potential has led to an upsurge in plants research 22 . They have also been found to contain antifungal activity, a wide range of antibiotics, they are a good coating agent, chelate free radicals and reactive oxygen species, increases the formation of capillaries and fibroblast, form complexes with proteins of cell wells 20 . Phenols stimulate PGE formation based on their activities as a co-substrate for peroxidase reaction 21 .…”

Section: Phytochemical Screeningmentioning

confidence: 99%

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Antifungal Potential of silver nanoparticles from Acacia nilotica Pod against Dermatophytes

Saheed

2021

J. Drug Delivery Ther.

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Background: Superficial fungal infections can lead to systemic infection in immune-compromised individuals. Acacia nilotica pod have been used ethnomedical to treat dermatophytes infection for ages. In this study, the anti-dermatophytes potential of silver nanoparticles biogenically synthesized using extracts from pod of A. nilotica against dermatophytes isolated from secondary care hospital in Damaturu, North-East Nigeria. Experimental:Phytochemical screening and GC-MS analysis were conducted to screen the phytoconstituents of the plant material. The synthesized AgNPs were characterized by Uv-vis, FT-IR, and SEM. 133 samples (skin scraping) were screened for dermatophytes and antifungal susceptibility testing were conducted against the isolates using aqueous, methanolic extracts, and AgNPs. Results: Phytochemical screening revealed the presence of alkaloids, flavonoids, glycosides, oxalate, quinones, phenols, saponins, terpenoids, GS-MS revealed the presence Polyphenolics including Hexadecenoic, Octadecanoic and Undecanoic acids, Catechol, pyrogallol, 3-methylpyridine and methylmannose. Uv-vis of synthesized AgNPs exhibited double sharp absorbance at 308nm and 311nm, FT-IR showed functional groups, thus, OH, C – H, C≡N, and C=O stretches of phenolics, alkenes, nitrile, and ketones respectively, and SEM showed various characteristic shapes and sizes. out of 133 samples collected, 54% were male and the age group with the highest clinical presentation were51 – 60, followed by 1 – 10years. according to clinical presentation, Tinea pedis (36%) and T. capitis (29%) were the commonest which may be due to constant contact with water and limited hair care. Aetiologic agents isolated include Trichophyton mentagrophyles (51%), T. rubrum (34%), and T. tonsurans (14%), although, there is no significant relationship between the clinical presentation and disease agent (p-value < 21.3 at 95% confidence level). AgNPs showed wider consistent zones of inhibitions against all the isolates. Discussion: A. nilotica is indeed very rich in polyphenolics. Foot and hair infections commonest in the study could be due to current weather conditions but sharing of footwear, caps, and brushes should be discouraged. Conclusion: This study opens up possibilities for exploration of this eco and economic approach of improving the medicinal value of plants, an opportunity the pharmaceutical industries can utilize. This study is the first to report prevalence of dermatophytes in the area &explored the AgNPs against it.

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“…The yield is presented in table 1. The percentage of yield is relatively close to the one earlier reported 20 .…”

Section: Collection Of Plant Materials Phytochemical Screening and Gc-ms Analysis Of Acacia Nilotica Podsupporting

confidence: 89%

Section: Collection Of Plant Materials Phytochemical Screening and Gc-ms Analysis Of Acacia Nilotica Podmentioning

confidence: 85%

Section: Phytochemical Screeningmentioning

confidence: 99%

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Antifungal Potential of silver nanoparticles from Acacia nilotica Pod against Dermatophytes

Saheed

2021

J. Drug Delivery Ther.

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“…The Froth test is used to detect saponins. A froth/foam formation indicates the presence of saponins (honeycomb froth) [ 25 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. Saponins are amphiphilic glycosidic secondary metabolites with foaming properties, which are produced by plants [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

Methods for Rapid Screening of Biologically Active Compounds Present in Plant-Based Extracts

et al. 2022

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In recent years, there has been an increased interest in products of natural origin. The extraction procedure of bioactive compounds from plant matrices is a crucial step in the development of useful new bioproducts for everyday life. The utilisation of analyses enabling the rapid identification of the presence of a given group of compounds can be helpful in the early stages of the development of new products in order to save time and reduce costs. Within this article, we have presented a comparison of different, accessible methods for the identification of various bioactive compounds, e.g., saponins, carboxylic acids, oils and fats, proteins and amino acids, steroids, and alkaloids in plant-based extracts. Additionally, the multielemental composition of extracts was also examined. The applied methods allowed for confirmation of the presence of biologically active compounds in bio-products obtained by ultrasound-assisted extraction. At a later stage, these procedures should be supplemented by advanced analytical techniques in order to determine the plant chemicals’ content qualitatively and quantitatively.

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“…Terpenes are essential plant oils. In human, they can induce biosynthesis of neurotransmitters such as serotonin a central nervous system neurotransmitter derived from the amino acid tryptophan involved in regulating mood, sleep, appetite, and sexuality & dopamine a neurotransmitter involved in motivation, reward, addiction, behavioral reinforcement, and coordination of bodily movement [43].…”

Section: Introductionmentioning

confidence: 99%

Biochemistry, Medicinal Properties & Toxicity of Acacia Nilotica Fruits

Abdalla¹

2021

BRCR

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Acacia nilotica tree is native to Africa, the Middle East and the Indian subcontinent. Due to its wide medicinal properties & uses this plant attracted the attention of many scientists. Its fruits are rich in more than 16 classes of different bioactive molecules & elements very beneficial for human health. These molecules & elements include tannins, saponins, phytosterols, cyclitols, alkaloids, anticoagulant agents, regulatory molecules, amines, mucilage, fibers, gums, proteins, various classes of amino acids, carbohydrates, terpenses, crude fats, oils, fatty acids & minerals. The fruits are used to treat various human disorders including cancers, heart & liver diseases, diabetes mellitus, malaria, asthma, arrhythmias, acquired immune-deficiency syndrome, coronavirus disease 2019, spleen disorders, for weight loss, colds, congestion, coughs, diarrhea, dysentery, fever, gallbladder, hemorrhage, hemorrhoids, leucorrhea, ophthalmia, sclerosis, tonsillitis, pharyngitis, skin eruptions smallpox and tuberculosis. Acacia nilotica fruits are very beneficial for human health, safe & effective to treat various human diseases if it is used in appropriate dose & period. It has been in use in Sudan & in other parts of Africa widely & safely for generations to treat various diseases without any reports of toxicity or adverse effects. Moreover, human body has efficient detoxification mechanisms to process and detoxify toxic substances and toxicity in human occurs only from known high toxic substances, overdose, regular and long period of using of herbs or medicines with known side effects. It is apparent that toxicity of acacia nilotica fruits comes from over dosage & longer than required duration of uses or regular consumption and the solvent/s as well. However, further works are needed by pharmaceutical industries to authentically formulate various components of the of acacia nilotica fruits to be used as medicines & supplements to enhance the therapy of several human diseases.

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Phytochemical screening and antimicrobial activities studies ofAcacia niloticafruit cover

Cited by 12 publications

References 13 publications

Antifungal Potential of silver nanoparticles from Acacia nilotica Pod against Dermatophytes

Antifungal Potential of silver nanoparticles from Acacia nilotica Pod against Dermatophytes

Methods for Rapid Screening of Biologically Active Compounds Present in Plant-Based Extracts

Biochemistry, Medicinal Properties & Toxicity of Acacia Nilotica Fruits

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