Phytochemical screening and anti-implantation activity of Asparagus africanus root extract in female Sprague–Dawley rats

El-Ishaq, Abubakar; Alshawsh, Mohammed Abdullah; Mun, Kein Seong; Chik, Zamri

doi:10.1016/j.bjp.2019.06.003

Cited by 9 publications

(3 citation statements)

References 19 publications

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“…Among the plants that help raise testosterone levels and produce pro-sexual stimulatory effects in male rats are Citropsis articulata, Cola acuminata, Ekebergia capensis, Plumbago zeylanica, Tarenna graveolens, Urtica massaica, and Zingiber officinale [Table 2]. [37] ANTI-IMPLANTATION ACTIVITY Ethanolic root extract of Asparagus africanus [38] and Calotropis gigantea showed in strong anti-implantation activity in female rats. [39,40] This activity may be due to presence of active principles of glycosides, cardenolides, and calotropin.…”

Section: Anti-ovulation Activitymentioning

confidence: 99%

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2024

IJGP

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This review examines the effects of plant origin various contraceptives on ovulatory events, egg transport, toxic action on eggs, end of implantation stages, and implantation through hypothalamic and pituitary controls. Plant-origin products modify the hormonal environment of fertilized eggs or developing ovums by the use of steroids and other chemicals. These herbal contraceptives affect spermatogenesis and lowers down the number of spermatocytes, intromission, and ejaculation frequencies. These also inhibit sperm production in males and obstruct fertilization in females. These herbal agents successfully obstruct reproduction and control the production, release, and action of hormones. Plant natural products work by blocking the effects of antiandrogens, which affect menstruation and pregnancy, cause birth, and birth control. This review explains the anti-fertility action of many plant species with active ingredients. It is important to understand the long-term effects of plant natural products on body metabolism to prevent undesired toxicity to other organs. These might have more effective role in the regulation of fertility and breakdown of pregnancy. These could be used for longterm family planning equally by both male and female partners. There is a great need for effective, reversible, and safe contraceptives for men and women, but the mechanisms of action of plant extracts and active compounds have yet to be determined.

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Section: Anti-ovulation Activitymentioning

confidence: 99%

Untitled

2024

IJGP

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“…Linn 43,44 Tabernaemontana divaricate 45,46 Jatropha gossypifolia 47 Alstonia scholaris 48 Curcuma longa 49 Piper betel 50 Cordia dichotoma 51 Hymenocardia acida 52 Heliotropium indicum 53 Rivea hypocratiriformis 77 Asparagus africanus 78…”

Section: Caesalpina Pulcherrimamentioning

confidence: 99%

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2022

IJPSR

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Along with increasing availability and utilization of contraception, it is also important to confirm that the effects of contraception use on resumption of fertility after discontinuation and serious adverse effects produced by synthetic steroidal contraceptives remained a major problem. However, current evidence on resumption of fertility after contraception use is inconclusive, and practically fertility after termination of contraception remains a big concern for women who are using contraception. This fear poses a negative impact on utilization and continuation of contraception. Therefore, the development of new fertility regulating drug from medicinal plants is an attractive proposition. So available reports and identifying the associating factors are important for designing a strategy to overcome the problem. Methods: The review is conducted through a systematic literature search of research articles. Few bibliographic databases and libraries: Pub Med/Medline, Global Health Database, Science direct, Embase, the Cochrane Library were used. Results: The review of different database studies that enrolled profiles of various medicinal plants used for contraception was analyzed. Conclusion and Recommendation:Contraceptive use, regardless of its duration and type, does not have a (negative) effect on the ability of women to conceive following termination of use, and it does not significantly delay fertility, but the serious adverse effects associated with synthetic steroidal contraceptives are definite and significant. So, it can be recommended to develop contraceptives from herbal medicinal plants with the least toxicity and more efficacy.INTRODUCTION: Anti-fertility agents are drugs that control fertility 1 and are also called oral contraceptives. These drugs affect and are involved in the menstrual cycle and ovulation in females. Estrogen and progesterone in combined form are QUICK RESPONSE CODE

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“…Previous phytochemical studies have led to the isolation of steroidal sapogenins (Debella et al, 1999), nor-lignans (Oketch-Rabah et al, 1997), sesquiterpenes, alkaloids, stigmasterols and phenolic compounds (El-Ishaq et al, 2019a;2019b).…”

Section: Introductionmentioning

confidence: 99%