Phytochemical-rich vegetable and fruit juice alleviates oral mucositis during concurrent chemoradiotherapy in patients with locally advanced head and neck cancer

Chang, Hern-Jia; Huang, Meng‐Chuan; Lei, Yen-Ping; Chuang, Yun-Ju; Wang, Chun-Wei; Sheen, Lee‐Yan

doi:10.1016/j.jtcme.2022.03.004

Cited by 4 publications

(3 citation statements)

References 55 publications

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“…Once patients are introduced to these toxic agents, the body system immediately produces ROS by activating the nuclear factor-kB (NF-kB) signaling transduction cascade, which promotes proinflammatory cytokines secretions. These pro-inflammatory cytokines, such as TNF-a, IL-1b, and IL-6 secretions, reactivate the MAPK cascade, and the combination of all the above processes induces the mucosal lesion (57). Remarkably, Mentha spicata extracts exhibited reduced IL-1β cytokines and intestine histological improvement in irinotecan-induced mucositis rats (58).…”

Section: Mucositismentioning

confidence: 99%

“…Moreover, evidence stated that polyphenol in Ananas comosus speeds up the oral ulcer healing time by stimulating the fibroblast cell proliferation (57). Next, the Piper betle extract has effective antiulcerogenic properties where it protects the ulcer area by inducing mucus production, reducing damaged proteins, and increasing the free radicals scavenging process (63).…”

Section: Mucositismentioning

confidence: 99%

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Anti-Cancer Properties of Locally Available Natural Products in Malaysia Against Colorectal Cancer

Gururuloo,

Shahpudin,

Sandai

et al. 2023

JUMMEC

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Colorectal cancer (CRC) has become a significant worldwide health issue among Malaysians. It has become the second most common disease among men and women, with an increased mortality rate in recent years. CRC cases can be reduced with a healthy diet by increasing natural product intake. However, today most of the commercialized natural products for CRC prevention are imported and costly, which makes 80% of the Malaysian population could hardly afford them due to low and middle household income. Therefore, the present study summarizes the list of local tropical natural products that have remarkable medicinal properties effective on CRC, which are easily accessible for Malaysians, ways to consume them at home, and the economic prospects. This narrative review reviews the latest natural products' properties against CRC, excluding the plants examined in previous studies. The keywords utilized to identify the relevant articles were “Malaysia," "Colorectal Cancer," “Natural products," “Anticancer," "Antidiarrheal," "Mucositis," and "Vomit/Nausea" through PubMed, ScienceDirect, and Google Scholar. Conclusion: In conclusion, the locally available natural products have excellent medicinal properties against colorectal cancer with enormous potential medicinal properties in treating CRC and chemotherapy-induced toxicity that Malaysians can use to improve their well-being.

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Section: Mucositismentioning

confidence: 99%

Section: Mucositismentioning

confidence: 99%

Anti-Cancer Properties of Locally Available Natural Products in Malaysia Against Colorectal Cancer

Gururuloo,

Shahpudin,

Sandai

et al. 2023

JUMMEC

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“…The ulcerative phase is the one that harms the patient's quality of life since there is a greater susceptibility to infections due to the breakdown of the mucosal barrier [9]. OM is the most common comorbidity observed during chemoradiotherapy in virtually all patients with oral squamous cell carcinoma (SCC), being classified by the WHO from grade zero to grade V, according to the observed clinical severity [10][11][12]. The complex origin of OM involving local and systemic predisposing factors makes it difficult to adopt treatments that are at the same time effective, easy to use, and inexpensive for patients.…”

Section: Introductionmentioning

confidence: 99%

Grade IV oral mucositis treatment with Brazilian green propolis mucoadherent gel

Silva,

Caldeira,

de Sousa

et al. 2023

Explor Drug Sci

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Green propolis is collected by Apis mellifera from the flowers and buds of Baccharis dracunculifolia. It has several chemical compounds that confer anti-inflammatory, antimicrobial, healing, and antioxidant biological activities. To report a series of clinical cases in the treatment of oral mucositis (OM) in patients with cancer undergoing radiotherapy in the head and neck region. Rapid treatment of OM means restoring quality of life to patients and lowering the cost of cancer treatment for public health. There male patients with oral carcinoma undergoing radiotherapy treatment were followed between August 2018 and April 2019. The patients presented themselves to the clinics in the Faculty of Dentistry of Federal University of Minas Gerais with erythematous and ulcerated coalescing lesions with purulent fibrin pseudomembranes in the oral mucosa, classified as grade IV OM according to the World Health Organization. The patients complained about the inability to eat, drink, and speak, which caused the radiotherapy interruption. After completing the clinical forms, anamnesis, and proper oral hygiene of each patient, a mucoadherent gel containing 5% propolis was prescribed for daily use, with a 3 time-a-day application every 8 h. After 7 days of use, there was an 80% lesion reduction, with total remission after 15 days of its application. The rapid response with total remission of lesions seems to be related to the chemical composition of propolis. Clinical and cellphone monitoring of patients, weekly and daily, respectively, were essential for successful treatment. The patients were monitored for one year, being encouraged to make constant use of the gel to control hyposalivation caused by changes in the salivary glands during radiotherapy.

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Influence of the microbiome on radiotherapy-induced oral mucositis and its management: A comprehensive review

Forné¹,

Anaya

Guillot

et al. 2023

Oral Oncology

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Phytochemical-rich vegetable and fruit juice alleviates oral mucositis during concurrent chemoradiotherapy in patients with locally advanced head and neck cancer

Cited by 4 publications

References 55 publications

Anti-Cancer Properties of Locally Available Natural Products in Malaysia Against Colorectal Cancer

Anti-Cancer Properties of Locally Available Natural Products in Malaysia Against Colorectal Cancer

Grade IV oral mucositis treatment with Brazilian green propolis mucoadherent gel

Influence of the microbiome on radiotherapy-induced oral mucositis and its management: A comprehensive review

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