Phytochemical profiling and antioxidant potential of Daphne mucronata Royle and action against paracetamol-induced hepatotoxicity and nephrotoxicity in rabbits

Nazir, Nausheen; Muhammad, Jebran; Ghaffar, Rukhsana; Nisar, Mohammad; Zahoor, Muhammad; Uddin, Faheem; Ullah, Riaz; Alotaibi, Amal

doi:10.1016/j.sjbs.2021.05.051

Cited by 14 publications

(4 citation statements)

References 36 publications

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“…In this study, the level of MDA in the lung tissue of BLM-receiving animals showed a marked increase, which was consistent with the findings of Yang et al [ 42 ]. In this context, Nazir et al [ 43 ] documented that Daphne mucronata Royle exhibit antioxidant properties in the paracetamol-induced hepatotoxicity by reducing lipid peroxidation, which was characterized by a decrease in the MDA level. Furthermore, Betulin is reported to be a direct scavenger of free oxygen radicals in high-fat diet-induced non-alcoholic fatty liver disease by mitigating oxidative stress [ 44 ] .…”

Section: Discussionmentioning

confidence: 99%

Betulin-rich hydroalcoholic extract of Daphne oleoides attenuates bleomycin-induced pulmonary fibrosis in rat

Danaei,

Sadeghi,

Asfaram

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

Betulin-rich hydroalcoholic extract of Daphne oleoides attenuates bleomycin-induced pulmonary fibrosis in rat

Danaei,

Sadeghi,

Asfaram

et al. 2023

Heliyon

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“…In addition, when combined with opioid analgesics, PTL can treat more severe pain, like post-operative pain and palliative care for advanced cancer patients (Popiolek and Porebski 2022 ). Although it is commonly considered safe and tolerable, overdose or excessive use can have serious consequences, including hematotoxicity (Yousef et al 2010 ), gastric ulcers (Rainsford and Whitehouse 2006 ), hepatotoxicity (Cairns et al 2019 ), impaired reproductive function (Pereira et al 2020 ), and kidney injury (Nazir et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase-3 immunoexpression and oxidative damage induced by paracetamol in male rats

Fadil

Behairy

Ebraheim

et al. 2023

Environ Sci Pollut Res

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This study investigated the possible protective role of mulberry leaf (MLE) and olive leaf (OLE) ethanolic extracts against paracetamol (PTL)–induced liver injury in rats compared to silymarin as a reference drug. Initially, MLE and OLE were characterized using gas chromatography–mass spectrometry (GC/MS). Then, forty male Sprague Dawley rats were divided into five groups: the negative control group orally received distilled water for 35 days, the PTL-treated group (PTG) received 500 mg PTL/kg b. wt. for 7 days, the MLE-treated group (MLTG) received 400 mg MLE/kg b. wt., the OLE-treated group (OLTG) received 400 mg OLE/kg b. wt., and the silymarin-treated group (STG) received 100 mg silymarin/kg b. wt. The last three groups received the treatment for 28 days, then PTL for 7 days. The GC–MS characterization revealed that MLE comprised 19 constituents dominated by ethyl linoleate, phytol, hexadecanoic acid, ethyl ester, and squalene. Moreover, OLE comprised 30 components, and the major components were 11-eicosenoic acid, oleic acid, phytol, and à-tetralone. MLE and OLE significantly corrected the PTL-induced normocytic normochromic anemia, leukocytosis, hypercholesterolemia, and hypoproteinemia. Moreover, the MLE and OLE pretreatment considerably suppressed the PTL-induced increment in serum levels of hepatic enzymes, including alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase. Furthermore, the PTL-induced depletion in antioxidant enzymes, including glutathione peroxidase, superoxide dismutase, and catalase, and the rise in hepatic malondialdehyde content were significantly reversed by the MLE and OLE pretreatment. Besides, MLE and OLE pretreatment significantly protected the hepatic tissue against PTL-induced DNA damage, pathological perturbations, and increased caspase 3 and CYP2E1 immunoexpression. Of note, OLTG showed better enhancement of most indices rather than MLTG. Conclusively, these findings imply that OLE, with its antioxidant and antiapoptotic capabilities, is superior to MLE in protecting against PTL-induced liver injury.

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“…Practical variations happen in the cell membrane as a consequence of the peroxidation of lipid [ 10 ]. CCl 4 is a potent lipid-soluble hepatotoxin bound to lipid and protein, and is used to enhance the peroxidative process [ 11 ]. Its toxic effect is dependent on the excessive production of the trichloromethyl peroxyl radical (CCl 3 • ) [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Renoprotective and Cardioprotective Potential of Moricandia sinaica (Boiss.) against Carbon Tetrachloride-Induced Toxicity in Rats

Shahat

Hassanein

Ullah

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The goal of the current study was to assess the nephroprotective and cardioprotective potential of Moricandia sinaica methanol extract (MOR-1), as well as its butanol (MOR-2) and aqueous (MOR-3) fractions against carbon tetrachloride (CCl4)-induced nephro and cardio-toxicity. Cardiac function was assessed using the biochemical parameters lactate dehydrogenase (LDH) and creatinine kinase (CK). Renal function was examined using the biochemical parameters creatinine and uric acid. The levels of nonprotein sulfhydryls (NPSH) and malondialdehyde (MDA) were used as markers of oxidative strain. A dose of 100 and 200 mg/kg of butanol fraction given prior to CCl4 treatment significantly ( p < 0.05 − 0.001 ) protected against elevated LDH and CK levels. Similarly, treatment with silymarin (10 mg/kg) and butanol fraction (100 and 200 mg/kg) significantly ( p < 0.05 − 0.001 ) boosted total protein levels compared to CCl4 treatment alone. The silymarin (10 mg/kg) and butanol fraction (100 and 200 mg/kg) also provided a significant ( p < 0.05 − 0.001 ) protective effect for MDA levels. Methanol extract (MOR-1) and butanol (MOR-2) showed significant results and were recommended for further pharmacological and screening for active constituents.

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Phytochemical profiling and antioxidant potential of Daphne mucronata Royle and action against paracetamol-induced hepatotoxicity and nephrotoxicity in rabbits

Abstract: Graphical abstract

Cited by 14 publications

References 36 publications

Betulin-rich hydroalcoholic extract of Daphne oleoides attenuates bleomycin-induced pulmonary fibrosis in rat

Betulin-rich hydroalcoholic extract of Daphne oleoides attenuates bleomycin-induced pulmonary fibrosis in rat

The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase-3 immunoexpression and oxidative damage induced by paracetamol in male rats

Renoprotective and Cardioprotective Potential of Moricandia sinaica (Boiss.) against Carbon Tetrachloride-Induced Toxicity in Rats

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