Phytochemical profiles of the leaves of Stizolophus balsamita and Psephellus sibiricus and their chemotaxonomic implications

Nawrot, Joanna; Budzianowski, Jaromir; Nowak, Gerard

doi:10.1016/j.phytochem.2018.12.022

Cited by 11 publications

(14 citation statements)

References 26 publications

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“…Moreover, compounds from natural products, including resveratrol, carvacrol, and apamin, also inhibit VSMC proliferation and neointima formation . As described previously, scoparone affects cellular functions, including VSMC proliferation, via control of intracellular signals . In the present study, we found that PDGF‐BB‐stimulated migration and wound healing were inhibited in VSMCs treated with scoparone, which reverted to the basal conditions of VSMC proliferation and migration without PDGF‐BB stimulation.…”

Section: Discussionsupporting

confidence: 84%

Inhibitory effects of scoparone from chestnut inner shell on platelet‐derived growth factor‐BB‐induced vascular smooth muscle cell migration and vascular neointima hyperplasia

et al. 2019

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BACKGROUND: Compounds of the inner shell of chestnut (Castanea crenata) have diverse biological activities, including anti-cancer and anti-oxidant activities. Here we explored the effects of an extract of chestnut inner shells and of its bioactive component scoparone on vascular smooth muscle cell migration and vessel damage. RESULTS:The ethanol extract of chestnut inner shells, containing 11 major compounds, inhibited platelet-derived growth factor (PDGF)-BB-induced migration of rat aortic smooth muscle cells (RASMCs). Among these compounds, scoparone (6,7-dimethoxycoumarin) suppressed RASMC migration and wound healing in response to PDGF-BB but did not affect RASMC proliferation. In RASMCs, scoparone inhibited the PDGF-BB-induced rat aortic sprout outgrowth and attenuated the PDGF-BB-mediated increase in phosphorylation of mitogen-activated protein kinases (MAPKs), p38 MAPK and extracellular signal-regulated kinase 1/2. The in vivo administration of scoparone resulted in the attenuation of neointima formation in balloon-injured carotid arteries of rats.CONCLUSION: These findings demonstrate that scoparone, found in chestnut inner shells, may inhibit cell migration through suppression of the phosphorylation of MAPKs in PDGF-BB-treated RASMCs, probably contributing to the reduction of neointimal hyperplasia induced after vascular injury. Therefore, scoparone and chestnut inner shell may be a potential agent or functional food, respectively, for the prevention of vascular disorders such as vascular restenosis or atherosclerosis. Cell isolation and cultureAll experiments were performed, and animal care was undertaken, in accordance with the institutional guidelines of Konkuk University. RASMCs were isolated from the thoracic aortas of five-week-old male Sprague Dawley (SD) rats (n = 6) and were cultivated in Dulbecco's modified Eagle medium (DMEM; Welgene, Korea) supplemented with 10% fetal bovine serum (FBS), 100 U mL −1 penicillin, 100 mg mL −1 streptomycin, and 200 mmol L −1 L-glutamine. For all experiments, RASMCs at passages 5-8 were grown to 70-80% confluence.

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Section: Discussionsupporting

confidence: 84%

Inhibitory effects of scoparone from chestnut inner shell on platelet‐derived growth factor‐BB‐induced vascular smooth muscle cell migration and vascular neointima hyperplasia

et al. 2019

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“…28) recorded in DMSO- d 6 , is also provided in this article. The typical NMR data for these compounds, including OH resonances, like chemical shifts, multiplicity and coupling constants, are reported in the main article [1]. Generally, as can be seen in the case of compound 5 , two OH groups resonated much more downfield in DMSO- d 6 (range 5.2–5.8 ppm) than in CDCl 3 (range 2.0–2.6 ppm).…”

Section: Datamentioning

confidence: 91%

“…In the course of our investigations [1], it emerged that hydroxyl groups (OH) are best detected in the NOESY spectrum, which usually serves for the stereochemical studies (e.g. [2], [3], [4]).…”

Section: Datamentioning

confidence: 99%

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NMR data for the hydroxyl groups detected by NOESY spectra in sesquiterpene lactones

2019

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In this article we present the correlations observed in the NOESY spectra, which provide direct and unequivocal detection of hydroxyl groups occurring in the chemical structures of three sesquiterpene lactones - a germacranolide (8α-( E ) - 4′-hydroxysenecioyloxy-9α-hydroxyparthenolide) and two guaianolides (cynaropicrin and desacylcynaropicrin 8α-( Z )-(4′-hydroxy-2′-methyl)butenoate). The NOESY spectra and other NMR spectra, which served for the structural determination, are also presented. The data provided in this article are associated with the research article “Phytochemical profiles of the leaves of Stizolophus balsamita and Psephellus sibiricus and their chemotaxonomic implications” Nawrot et al., 2019.

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“…For this study, Stizolophus balsamita ( S. balsamita ) (Lam.) K.Koch from Iran was chosen, as no less than seven parthenolide derivatives were found in it [14].…”

Section: Introductionmentioning

confidence: 99%

The Anti-Serotonin Effect of Parthenolide Derivatives and Standardised Extract from the Leaves of Stizolophus balsamita

Nawrot

Napierała²,

Kaczerowska-Pietrzak

et al. 2019

Molecules

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The presence of dominant active compounds in standardised methanol extract from the leaves of Stizolophus balsamita (S. balsamita) was examined using HPLC with a diode-array detector. The extract and three dominant parthenolide derivatives were tested with Serotonin Research ELISA for their ability to inhibit the serotonin release from platelets. The antiserotonin effect of the extract was compared with that of parthenolide, a compound with proven antiserotonin and antimigraine effects. This study aimed to evaluate the ability of natural parthenolide derivatives to inhibit serotonin release from platelets. Izospiciformin, stizolin and stizolicin were analysed along with the standardised alcohol extract of S. balsamita leaves, which also contained four other parthenolide derivatives. All the analysed substances were found to inhibit serotonin release from platelets as compared with the control sample, which had 100% of serotonin released. Izospiciformin had the most significant impact (97.98% serotonin release inhibition). The effect of the methanol extract of S. balsamita on the serotonin release inhibition was also statistically significant.

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Phytochemical profiles of the leaves of Stizolophus balsamita and Psephellus sibiricus and their chemotaxonomic implications

Cited by 11 publications

References 26 publications

Inhibitory effects of scoparone from chestnut inner shell on platelet‐derived growth factor‐BB‐induced vascular smooth muscle cell migration and vascular neointima hyperplasia

Inhibitory effects of scoparone from chestnut inner shell on platelet‐derived growth factor‐BB‐induced vascular smooth muscle cell migration and vascular neointima hyperplasia

NMR data for the hydroxyl groups detected by NOESY spectra in sesquiterpene lactones

The Anti-Serotonin Effect of Parthenolide Derivatives and Standardised Extract from the Leaves of Stizolophus balsamita

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