Phytochemical Profiles of Albizia coriaria, Azadirachta indica, and Tylosema fassoglensis Used in the Management of Cancers in Elgon Sub-Region

Kudamba, Ali; Kafeero, Hussein Mukasa; Lubowa, Muhammad; Okurut, Shaban A.; Nsubuga, Hakim; Abiti, Twaha; Kayendeke, Joweria; Walusansa, Abdul; Ssenku, Jamilu E.

doi:10.26502/fjhs.073

Cited by 9 publications

(10 citation statements)

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“…All the plants scored high delity level index (above 70) and plant value (above 60). Our earlier study [52], also revealed that Tylosema fassoglensis, harvested from Elgon region had high concentration of tannin, alkaloids, polyphenols, and avonoids the than when it is grown elsewhere in the world [41].…”

Section: Discussionmentioning

confidence: 74%

Anticancer Medicinal Plants Used by Residents in the Elgon Sub-region, Eastern Uganda

Kudamba,

Kasolo,

Bbosa

et al. 2023

Preprint

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Background: In Uganda, medicinal plants have been utilized to treat a variety of ailments, including cancer. The anticancer medicinal herbs employed in the Elgon sub-region, however, have only been the subject of a relatively small number of investigations. This study's major objective was to document the anticancer medicinal plants used to treat cancer in the Elgon sub-region of eastern Uganda, with a focus on prostate cancer. Methods: A semi-structured questionnaire that was administered by the researcher, interview guides, and guided field trips were used to collect ethnobotanical data. A number of quantitative indices were assessed, including informant consensus factor (ICF), fidelity level (FL), and preference ranking. A descriptive statistical analysis and graphs were produced using SPSS version 21.0 and GraphPad Prism version 8.125 respectively. The narratives were then interpreted using major theories and hypotheses in ethnobotany. Results: A total of 50 plant species from 36 families were documented and herbal knowledge was mainly acquired through inheritance. Most of the plant species revealed in this study belonged to the Fabaceae and Asteraceae families. Hydnora abyssinica A. Br. was mostly recommended by herbalists for prostate, cervical, and breast malignancies. Tylosema fassoglensis was the most favored in regard to its ability to treat all known cancers in the area. The majority were collected from forest reserves (63%); herbal therapies were made from herbs (45%); and were primarily decocted (43%) from leaves (40%). Conclusions: The first 10 most often used plants all had FLI (71), ICF (0.8), and PV (60), values that were quite high, indicating that they are believed to be the most effective in treating the known cancers in this area. Therefore, further study is required to determine the phytochemistry, toxicity, and efficacy of these plants in order to develop a newer anticancer drug.

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Section: Discussionmentioning

confidence: 74%

Anticancer Medicinal Plants Used by Residents in the Elgon Sub-region, Eastern Uganda

Kudamba,

Kasolo,

Bbosa

et al. 2023

Preprint

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“…This is consistent with a previous study of ours that found a substantial preference for traditional cancer remedies over modern cancer therapies and other diseases among people in the rural Elgon sub-region and Butelejja district of eastern Uganda. 13 , 19 , 20 The increased use of herbal therapies has also been attributed to their affordability, claimed safety, accessibility, and, most importantly, their assumed effectiveness. 21 Gender is one of the notifiable factors influencing the use of herbal medicine, the significant use of herbal plants for disease treatment and has been linked to the region of residence, age, and education.…”

Section: Discussionmentioning

confidence: 99%

“… 12 It is expected that they rely on herbal plant extract to treat cancer, as is the case with other illnesses, due to the remoteness of most of East Africa. 13 The WHO reports that more than 80% of developing nations use traditional medicines, and they continue to be an excellent source of prospective therapeutics. 10 Several ethnobotanical surveys for plant species used to treat cancer have been undertaken in East African regional countries between 2019 and 2023.…”

Section: Introductionmentioning

confidence: 99%

Review of Herbal Medicinal Plants Used in the Management of Cancers in the East Africa Region from 2019 to 2023

Kudamba,

Kasolo,

Bbosa

et al. 2024

Integr Cancer Ther

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Background: In the East African region, herbal plants are essential in the treatment and control of cancer. Given the diverse ecological and cultural makeup of the regional states, it is likely that different ethnic groups will use the same or different plants for the same or different diseases. However, since 2019, this has not been compiled into a single study. Purpose: The study aimed to compile and record the medicinal plants utilized in East Africa from April 2019 to June 2023 to treat various cancer types. Materials and methods: The study examined 13 original studies that included ethnobotanical research conducted in East Africa. They were retrieved from several internet databases, including Google Scholar, Scopus, PubMed/Medline, Science Direct, and Research for Life. The study retrieved databases on plant families and species, plant parts used, preparation methods and routes of administration, and the country where the ethnobotanical field surveys were conducted. Graphs were produced using the GraphPad Prism 8.125 program (GraphPad Software, Inc., San Diego, CA). Tables and figures were used to present the data, which had been condensed into percentages and frequencies. Results: A total of 105 different plant species from 45 different plant families were identified, including Asteraceae (14), Euphorbiaceae (12), Musaceae (8), and Apocynaceae (7). Uganda registered the highest proportion (46% of the medicinal plants used). The most commonly mentioned medicinal plant species in cancer management was Prunus africana. Herbs (32%), trees and shrubs (28%), and leaves (45%) constituted the majority of herbal remedies. Most herbal remedies were prepared by boiling (decoction) and taken orally (57%). Conclusion: East Africa is home to a wide variety of medicinal plant species that local populations and herbalists, or TMP, frequently use in the treatment of various types of cancer. The most frequently used families are Asteraceae and Euphorbiaceae, with the majority of species being found in Uganda. The most frequently utilized plant species is Prunus africana. Studies on the effectiveness of Prunus africana against other malignancies besides prostate cancer are required.

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“…2 and Table 2). The distinctions can be attributable to the fact that different species' phytochemical compositions have been observed, even among members of the same family and plants cultivated in similar habitats [14]. With phenol at 97.58 ± 0.09 and avonoids at 97.47 ± 0.12, the levels of total phenol in our sample were higher (129.74 ± 0.587) but lower (11.01 ± 0.188) than in the report mentioned by [48].…”

Section: Fixed Oils and Fatsmentioning

confidence: 99%

Phytocphytochemical Profiles of Rhoicissus Tridentata Harvested From the Slopes of Mountain Elgon, Uganda

Kudamba,

Kasolo,

Bbosa

et al. 2023

Preprint

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Introduction: Prostate cancer remains a formidable threat in Uganda. As such, the quest to find novel, efficacious therapies with reduced side effects to avert this challenge is still ongoing. Medicinal plants are taking center stage in these efforts. In the Elgon sub-region of Eastern Uganda, Rhoicissus tridentata (L.f.) is one of the medicinal plants commonly used in the management of prostate cancer among communities and traditional herbalists but its phytochemical profiles responsible for toxicity activity have not fully been investigated. This impedes the potential usefulness of R. tridentata in developing improved anticancer biotherapeutics.to find novel, efficacious therapies with reduced side effects to avert this challenge is still ongoing. The current study investigated the phytochemical compositions of aqueous and methanol extracts of Rhoicissus tridentata used in the management of prostate harvested from the Elgon sub-region. Methods The root tubers were harvested from the mountain Elgon sub-region, identified and authenticated, cleaned, air-dried, pounded, and subjected to qualitative phytochemical profiling and spectrophotometry. The laboratory experiments were conducted at Islamic University in Uganda, Uganda Natural Chemotherapeutics Laboratories, and Makerere University. The data were analyzed using descriptive statistics with STATA version 15.0 software. Graphs were plotted using GraphPad Prism® version 9.0.0. Results The researchers found that Rhoicissus tridentata (L.f.) root tuber extracts were very rich in a number of phytochemical compounds that dissolve better in methanol than in ethanol. Polyphenols, tannins, glycosides, carotenoids, and flavonoids were significantly higher in methanol than in ethanol and water (p = 0.0022), while saponins were substantially higher in water (p = 0.0022). Conclusions Root tubers of Rhoicissus tridentata (L.f.) had several bioactive compounds, with the majority found in methanol as compared to water extract. The bioactive compounds observed were mainly polyphenols and flavonoids, and these have been reported to possess reputable anticancer properties. To help the pharmaceutical industry develop novel and more potent anticancer medications from plants such as R. tridentata, it is necessary to undertake in vitro and in vivo investigations on the plant extracts and to purify and characterize the most bioactive compounds.

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Phytochemical Profiles of Albizia coriaria, Azadirachta indica, and Tylosema fassoglensis Used in the Management of Cancers in Elgon Sub-Region

Cited by 9 publications

References 0 publications

Anticancer Medicinal Plants Used by Residents in the Elgon Sub-region, Eastern Uganda

Anticancer Medicinal Plants Used by Residents in the Elgon Sub-region, Eastern Uganda

Review of Herbal Medicinal Plants Used in the Management of Cancers in the East Africa Region from 2019 to 2023

Phytocphytochemical Profiles of Rhoicissus Tridentata Harvested From the Slopes of Mountain Elgon, Uganda

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