Phytochemical profiles and antioxidant, anticholinergic, and antidiabetic activities of Odontites serotina (Lam.) Dum

Zhang, Zhenyang; Dai, Le‐yao; Wang, Hanyu; Chang, Xuejian; Ren, Shimin; Lai, Hanpeng; Liu, Liang

doi:10.1016/j.eujim.2021.101340

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…For α-glucosidase-inhibitory activity, again the PCME was more effective with an inhibition value of 1.88 ± 0.15 mmol ACAE/g, respectively, while the results of other fractions showed that PCBF was more effective (0.95 ± 0.09 mmol ACAE/g), and a decrease in activity was observed with the decrease in polarity of fraction (PCCF = 0.78 ± 0.04 > 0.46 ± 0.01 mmol ACAE/g). Our finding was consistent with the reported evidence in literature in which an intimate positive correlation was found between TPC and TFC and in vitro antioxidant activity and various enzyme inhibition assays [109]. Moreover, some compounds were identified with antioxidant and anti-inflammatory effects by GCMS analysis of PCME and PCHF, which also contribute to the antidiabetic activity of the plant [110].…”

Section: In Vitro Enzyme Inhibition Activitiessupporting

confidence: 92%

Comprehensive Phytochemical Profiling, Biological Activities, and Molecular Docking Studies of Pleurospermum candollei: An Insight into Potential for Natural Products Development

et al. 2022

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The purpose of this study was to find the biological propensities of the vegetable plant Pleurospermum candollei by investigating its phytochemical profile and biological activities. Phytochemical analysis was done by spectroscopic methods to investigate the amount of total polyphenols, and biological evaluation was done by the different antioxidant, enzyme inhibitory (tyrosinase, α-amylase, and α-glucosidase), thrombolytic, and antibacterial activities. The highest amount of total phenolic and flavonoid contents was observed in methanolic extract (240.69 ± 2.94 mg GAE/g and 167.59 ± 3.47 mg QE/g); the fractions showed comparatively less quantity (57.02 ± 1.31 to 144.02 ± 2.11 mg GAE/g, and 48.21 ± 0.75 to 96.58 ± 2.30 mg QE/g). The effect of these bioactive contents was also related to biological activities. GCMS analysis led to the identification of bioactive compounds with different biological effects from methanolic extract (antioxidant; 55.07%, antimicrobial; 56.41%), while the identified compounds from the n-hexane fraction with antioxidant properties constituted 67.86%, and those with antimicrobial effects constituted 82.95%; however, the synergetic effect of polyphenols may also have contributed to the highest value of biological activities of methanolic extract. Molecular docking was also performed to understand the relationship of identified secondary metabolites with enzyme-inhibitory activities. The thrombolytic activity was also significant (40.18 ± 1.80 to 57.15 ± 1.10 % clot lysis) in comparison with streptokinase (78.5 ± 1.53 to 82.34 ± 1.25% clot lysis). Methanolic extract also showed good activity against Gram-positive strains of bacteria, and the highest activity was observed against Bacillus subtilis. The findings of this study will improve our knowledge of phytochemistry, and biological activities of P. candollei, which seems to be a ray of hope to design formulations of natural products for the improvement of health and prevention of chronic diseases; however, further research may address the development of novel drugs for use in pharmaceuticals.

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Section: In Vitro Enzyme Inhibition Activitiessupporting

confidence: 92%

Comprehensive Phytochemical Profiling, Biological Activities, and Molecular Docking Studies of Pleurospermum candollei: An Insight into Potential for Natural Products Development

et al. 2022

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“…Moreover, emodin and artinemol may be effective antiviral drugs for the treatment of patients with COVID-19 [28]. Emodin can be found in the roots, leaves, bark and trunk of several plants, such as Senna alata (Cassia alata) [12], Rumex abyssinicus [13], Odontites serotina [14], Reynoutria japonica [15], Polygonum cuspidatum [16]. The source of emodin in the human diet is rhubarb [17].…”

Section: Pharmacological Effects Of Emodinmentioning

confidence: 99%

The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update

Stompor-Gorący

2021

IJMS

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Emodin (6-methyl-1,3,8-trihydroxyanthraquinone) is a naturally occurring anthraquinone derivative found in roots and leaves of various plants, fungi and lichens. For a long time it has been used in traditional Chinese medicine as an active ingredient in herbs. Among other sources, it is isolated from the rhubarb Rheum palmatum or tuber fleece-flower Polygonam multiflorum. Emodin has a wide range of biological activities, including diuretic, antibacterial, antiulcer, anti-inflammatory, anticancer and antinociceptive. According to the most recent studies, emodin acts as an antimalarial and antiallergic agent, and can also reverse resistance to chemotherapy. In the present work the potential therapeutic role of emodin in treatment of inflammatory diseases, cancers and microbial infections is analysed.

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Bioactivity-guided isolation of anti-acetylcholinesterase compounds from Odontites vulgaris Moench

Liu,

Chang,

Dai

et al. 2023

Med Chem Res

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Phytochemical profiles and antioxidant, anticholinergic, and antidiabetic activities of Odontites serotina (Lam.) Dum

Cited by 8 publications

References 26 publications

Comprehensive Phytochemical Profiling, Biological Activities, and Molecular Docking Studies of Pleurospermum candollei: An Insight into Potential for Natural Products Development

Comprehensive Phytochemical Profiling, Biological Activities, and Molecular Docking Studies of Pleurospermum candollei: An Insight into Potential for Natural Products Development

The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update

Bioactivity-guided isolation of anti-acetylcholinesterase compounds from Odontites vulgaris Moench

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