Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity

Kontogianni, Vassiliki G.; Tomić, Goran; Nikolić, Ivana; Nerantzaki, Alexandra; Sayyad, Nisar; Stošić‐Grujičić, Stanislava; Stojanović, Ivana; Gerothanassis, Ioannis P.; Tzakos, Andreas G.

doi:10.1016/j.foodchem.2012.07.091

Cited by 304 publications

(256 citation statements)

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“…The present study, however, is based on aqueous extracts and preserved in sesame oil along with beehive wax as prepared for new treatment protocol [8][9][10][11]. Previous studies have supported the present therapy in respect to anti-inflammatory properties by the presence of phytochemicals in Calotropis gigantea [35,45], muscular pain relief and traditional treatment in osteoarthritis, rheumatoid arthritis and osteoporosis by using organic solvent extracts of Cissus quadrangularis [3,46,47], antioxidant activities by Heliotropium indicum [31] and essential oil from the areal part of plant, Rosemarinus officinalis have showed antiinflammatory, antiproliferative and antioxidant properties [32,48]. Moreover, all the previous studies with these medicinal plants traditionally and/or experimental may have served as temporarily in nature.…”

Section: Discussionmentioning

confidence: 78%

“…This is a pioneering observation that OA changes in knee joints having varus/valgus deformity can be normalised with the help of previously established medicinal plants [8][9][10][11]. However, only pain and inflammatory disorders have temporarily been relieved, which have been documented by few researchers using these medicinal plants as folk medicine traditionally [31][32][33][34][35][36] but present novel technology is based on aqueous extracts of above-mentioned plants within 42 sittings with specific treatments protocols thrice in a day with application procedure of the above-mentioned phytoconstitutents in especially postural positions of contra lateral and cross contra lateral [8,9].…”

Section: Resultsmentioning

confidence: 99%

“…The phytoconstituents such as di-and triterpenoids, phenolic acids and flavonoids were documented. Also found carnosic acid, carnosol and rosmarinic acid [32]. For Calotropis gigantea, the All above-mentioned plants were taken after drying properly, followed by pulverisation and squeezing in deionised water with occasional stirring for 48 hours at 25 ± 2ºC.…”

Section: Indian Medicinal Plants and Their Phytoconstituents Extractimentioning

confidence: 99%

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Normalization of Varus/Valgus Deformities in Osteoarthritis by External Application of Phytoconstituents: Confirmed With Anatomical Observations and Biochemical Profiles and Radiological Images

Ganguly¹

2016

Anat Physiol

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In India, a large number of patients are suffering with genu varum deformities during osteoarthritic (OA) changes in their knee joints. The malaligned knees are either varus (bow-legged) or valgus (knock-kneed) alignment. When the distal part is more medial, it is called varus deformity (≤178º) while the distal part is more lateral, it is called valgus deformity (≥182º). In OA changes of knee-joints, relieving of pain only was achieved temporarily by using medicinal plants based on traditional knowledge. However, correction of malalignment of genu varum by phytotherapeutic protocols has not been attempted as yet.The study was conducted on 196 patients (male: 65 and female: 131) aged ≥ 50 years old for genu varum deformities, normalized by the topical application of phytotherapeutic treatment protocol. To detect the normalization, anatomical measurements and biochemical parameters along with radiological images are being studied before (0 sitting) and after 42 sittings of the treatment. The present results clearly reveal that normalization of genu varum deformities are achieved by topical application of phytoconstituents (aqueous extracts) from acknowledged Indian medicinal plants (Cissus quadrangularis, Heliotropium indicum, Rosmarinus officinalis, Calotropis gigantea) with specialized treatment paradigm, within forty-two sittings.It is a pioneering study for complete recovery of malalignment of genu varum by phytotherapy, which can be an alternative novel method for normalization of genu varum. The present research is corroborated by before and after anatomical observations, biochemical parameters and radiological images.

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Section: Discussionmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Section: Indian Medicinal Plants and Their Phytoconstituents Extractimentioning

confidence: 99%

See 1 more Smart Citation

Normalization of Varus/Valgus Deformities in Osteoarthritis by External Application of Phytoconstituents: Confirmed With Anatomical Observations and Biochemical Profiles and Radiological Images

Ganguly¹

2016

Anat Physiol

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“…Moreover, both extracts exerted cytotoxic activity through dose-dependent impairment of viability and mitochondrial activity of rat insulinoma m5F (RINm5F) cells. Decrease of RINm5F viability was mediated by NO-induced apoptosis [35].…”

Section: Salvia Officinalis Salvia Officinalis L (Common Sagementioning

confidence: 95%

“…Based on literature data, carnosol, the phenolic diterpene found in rosemary, has potential to inhibit LPS-induced activation of two members of the mitogen-activated protein kinases, specifically extracellular signal-regulated kinase (ERK) and p38, and abrogated LPS-induced iNOS expression [34]. Study of Kontogianni et al [35] indicated immunomodifying activity of rosemary extract attributed to the presence of betulinic acid and higher concentration of carnosic acid in comparision to S. officinalis. Moreover, both extracts exerted cytotoxic activity through dose-dependent impairment of viability and mitochondrial activity of rat insulinoma m5F (RINm5F) cells.…”

Section: Salvia Officinalis Salvia Officinalis L (Common Sagementioning

confidence: 99%

Biological effects of four frequently used medicinal plants of Lamiaceae

Srančíková¹,

Horvathova²,

Kozics³

2014

neo

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Cancer is one of the leading causes of death characterized by uncontrolled growth and spread of cancer cells. There are several hundred thousands of new cases of cancer worldwide. Clinical oncology is still challenged by toxicity and side effects of multimodal therapy strategies in which it is associated with poor prognosis for patients. There is an urgent necessity to develop novel therapy strategies and to utilize preventive potential of natural compounds. As the majority of anticancer drugs are of natural origin, natural products represent a valuable source for the identification and development of novel treatment options and chemopreventive mechanisms for cancer. This review is focused on the summary of published knowledges on the antioxidant and potential chemopreventive effects of biologically active substances present in the extracts of four plants of the family Lamiaceae (sage, thyme, rosemary and lavander) in different animal and in vitro systems. It is assumed that the chemopreventive and chemotherapeutic potential of natural compounds is the result of a combined action of several mechanisms.

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Glassworts as Possible Anticancer Agents Against Human Colorectal Adenocarcinoma Cells with Their Nutritive, Antioxidant and Phytochemical Profiles

Altay

Celep

Yaprak

et al. 2017

Chemistry & Biodiversity

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In this study, the possible uses of glassworts as potential food ingredients and their antiproliferative activity against colorectal adenocarcinoma cells together with their antioxidant and phytochemical profiles were investigated for the first time. MeOH extracts of five different taxa collected from different localities were screened for their antioxidant capacities by DPPH (IC 2.91 - 5.49 mg/ml) and ABTS (24.4 - 38.5 μmol TE/g extract) assays. Salicornia freitagii exhibited the highest DPPH radical scavenging activity. LC/MS/MS analysis displayed that vanillic acid and p-coumaric acid were two main phenolic compounds in the extract. Salicornia freitagii extracts also exhibited high antiproliferative activity against HT-29 (IC 1.67 mg/ml) and Caco-2 (IC 3.03 mg/ml) cells for 72 h. Mineral analysis indicated that all the species with different proportions of elemental components contained high amount of cations. These results indicate that investigated glassworts, with their high phenolic and mineral contents and also notable antioxidant and cytotoxic properties, may be utilized as a promising source of therapeutics.

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Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity

Cited by 304 publications

References 29 publications

Normalization of Varus/Valgus Deformities in Osteoarthritis by External Application of Phytoconstituents: Confirmed With Anatomical Observations and Biochemical Profiles and Radiological Images

Normalization of Varus/Valgus Deformities in Osteoarthritis by External Application of Phytoconstituents: Confirmed With Anatomical Observations and Biochemical Profiles and Radiological Images

Biological effects of four frequently used medicinal plants of Lamiaceae

Glassworts as Possible Anticancer Agents Against Human Colorectal Adenocarcinoma Cells with Their Nutritive, Antioxidant and Phytochemical Profiles

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