Phytochemical profile of Paulownia tomentosa (Thunb). Steud.

Abstract

Paulownia tomentosa, a member of the plant family Paulowniaceae and a rich source of biologically active secondary metabolites, is traditionally used in Chinese herbal medicine. Flavonoids, lignans, phenolic glycosides, quinones, terpenoids, glycerides, phenolic acids, and miscellaneous other compounds have been isolated from different parts of P. tomentosa plant. Recent interest in this species has focused on isolating and identifying of prenylated flavonoids, that exhibit potent antioxidant, antibacterial, and antiphlogistic activities and inhibit severe acute respiratory syndrome coronavirus papain-like protease. They show cytotoxic activity against various human cancer cell lines and inhibit the effects of human cholinesterase, butyrylcholinesterase, and bacterial neuraminidases. Most of the compounds considered here have never been isolated from any other species of plant. This review summarizes the information about the isolated compounds that are active, their bioactivities, and the structure-activity relationships that have been worked out for them. major flavonoid of citrus, activity reviewed by Khan and Zill-E-Huma (2014) 114 R1= R2= R3=R4= H 121 R1= R2=R3=R4 = H 115 R1= OH (6S), R2= R3=R4= H 122 R1= OH (6S), R2=R3= R4= H 116 R1= R3=R4= H, R2= OH (7R) 123 R1= R3=R4= H, R2= OH (7R) 117 R1= R2=R4= H, R3= OH (8R) 124 R1= R2=R4= H, R3= OH (8R) 118 R1= R2=R3= H, R4= OH (9R) 125 R1= R2=R3= H, R4= OH (9R) 119 R1= R3=R4= H, R2= OAc (7R) 126 R1= R2=R4= H, R3= OAc (8R) 120 R1= R2=R4= H, R3= OAc (8R) 127 R1= R2=R3= H, R4= OAc (9R)

C-Geranylated Flavanones from Paulownia tomentosa Fruits as Potential Anti-inflammatory Compounds Acting via Inhibition of TNF-α Production

“…The reverse transcription step was performed with a Transcriptor Universal cDNA Master (Roche) using cell lysate as the template. The reaction consisted of three steps: (1) primer annealing at 29°C for 10 min, (2) reverse transcription at 55°C for 10 min, and (3) transcriptase inactivation at 85°C for 5 min. A Fast Start Universal Probe Master (Roche) and Gene Expression assays (Applied Biosystems) were used for qPCR.…”

“…1 This species is rich mainly in phenolics, such as flavonoids, phenylpropanoid glycosides, phenolic acids, and lignans. 2 Iridoids, sesquiterpene lactone, furanoquinone, and acylglycerols have also been isolated. 2 In particular, C-geranyl flavonoids obtained from P. tomentosa fruits have become the focus of phytochemical research because of their wide spectrum of biological activities.…”

“…2 Iridoids, sesquiterpene lactone, furanoquinone, and acylglycerols have also been isolated. 2 In particular, C-geranyl flavonoids obtained from P. tomentosa fruits have become the focus of phytochemical research because of their wide spectrum of biological activities. So far, 38 geranylated and two preny lated fl av onoids have be en isolated from P. tomentosa.…”

Paulownia tomentosa (Princess Tree) Extract Reduces DNA Damage and Induces DNA Repair Processes in Skin Cells

“…Paulownia plants are a rich source of phytochemistry documented by many studies and are reviewed comprehensively [41]. Expressed phytochemistry as a function of a part of the Paulownia tomentosa plant is shown in Table-1 below.…”

Identification of C -geranylated flavonoids from Paulownia catalpifolia Gong Tong fruits by HPLC-DAD-ESI-MS/MS and their anti-aging effects on 2BS cells induced by H 2 O 2

“…Previous phytochemical studies on Paulownia plants have led to the isolation of quinones [2] , lignans [3] , phenylpropanoid glycosides [4] , and C-geranylated flavonoids [5][6][7][8][9] . Up to date, more than 40 C-geranylated flavanones have been isolated from Paulownia plants, especially from P. tomentosa [10] . Some C-geranylated flavanones display cytotoxic [7,11] , antioxidant [5,11] , antiviral [12] , antibacterial [6,9] , anti-inflammatory [13] , and anti-cholinesterase activities [14] .…”