Phytochemical Profile and Antioxidant Capacity of Viscum album L. Subsp. album and Effects on Its Host Trees

Kleszken, Eva; Purcărea, C.; Pallag, Annamária; Ranga, Floricuţa; Memete, Adriana Ramona; Miere, Florina Groza; Vicaş, Simona Ioana

doi:10.3390/plants11223021

Cited by 16 publications

(15 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most of the studies amplified the research to other constituents to evidence how they may co-operate in the activity [ 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 ], including new phenolic compounds isolated from the whole plant [ 157 ]. In several papers, more activities are considered on the basis of a connection made between inflammation and many related pathologies [ 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 ]. In the medical point of view, inflammation is divided into acute and chronic inflammation, according to causes, symptoms and medical treatment.…”

Section: Introductionmentioning

confidence: 99%

The Anti-Inflammatory Activity of Viscum album

Nicoletti

2023

Plants

View full text Add to dashboard Cite

The therapeutic story of European mistletoe (Viscum album L.) presents a seesawing profile. In ancient times, this hemiparasitic plant was considered a panacea and even to be endowed with exceptional beneficial properties. In more recent times, despite its multiple uses in traditional medicines, some parts of the plant, in particular the berries, were considered poisonous and dangerous, including concerns of cytotoxicity, which spread serious suspicion on its medicinal utility. However, since the last century, medical interest in mistletoe has come back in force due to its utilization in clinical cancer treatments, based on its selective action on tumor cells. In Central Europe, the hydro-alcoholic extracts of European mistletoe register a relevant and continuous utilization in anthroposophic medicine, which is a holistic system that includes the utilization of phytomedicinal substances. In Switzerland and Germany, most physicians and patients use these products as complementary therapy in oncological treatments. However, despite its increasing use in this field, the results of mistletoe’s use are not always convincing, and other aspects have appeared. Nowadays, products that contain mistletoe are utilized in several fields, including diet, phytotherapy, veterinary medicine and homeopathy, but in particular in cancer therapies as coadjuvant factors, in consideration of several positive effects including effects in the improvement of quality-of-life conditions and reinforcement of the immune system. In this review, based on the understanding of the association between cancer and inflammation, we propose a relationship between these recent uses of mistletoe, based on its antioxidant properties, which are supported by phytochemical and pharmacological data. The unicity of mistletoe metabolism, which is a direct consequence of its hemiparasitism, is utilized as a key interpretation element to explain its biological properties and steer its consequent therapeutic uses.

show abstract

Section: Introductionmentioning

confidence: 99%

The Anti-Inflammatory Activity of Viscum album

Nicoletti

2023

Plants

View full text Add to dashboard Cite

show abstract

“…In addition, during the seed-to-seedling transition of any seed, metabolism is maintained by protein catabolism [ 85 ], and photosynthetic transcripts are down-regulated in both parasitic and other plants [ 128 ]. Chlorophyll and nitrogen contents from seedling establishment to adult life stages have been quantified in other Psittacanthus and mistletoe species [ 127 , 129 , 130 , 131 , 132 ]. Protease activity is directly related to protein catabolism, which in consequence impacts in the nitrogen and chlorophyll content in seeds, germination, and seedling development in P. calyculatus , which are development programs previous to seedling establishment [ 82 ].…”

Section: Discussionmentioning

confidence: 99%

Protein Profiling of Psittacanthus calyculatus during Mesquite Infection

Aguilar-Venegas

Quintana-Rodríguez²,

Aguilar-Hernández³

et al. 2023

Plants

View full text Add to dashboard Cite

Psittacanthus calyculatus is a hemiparasite mistletoe that represents an ecological problem due to the impacts caused to various tree species of ecological and commercial interest. Although the life cycle for the Psittacanthus genus is well established in the literature, the development stages and molecular mechanism implicated in P. calyculatus host infection are poorly understood. In this study, we used a manageable infestation of P. laevigata with P. calyculatus to clearly trace the infection, which allowed us to describe five phenological infective stages of mistletoe on host tree branches: mature seed (T1), holdfast formation (T2), haustorium activation (T3), haustorium penetration (T4), and haustorium connection (T5) with the host tree. Proteomic analyses revealed proteins with a different accumulation and cellular processes in infective stages. Activities of the cell wall-degrading enzymes cellulase and β-1,4-glucosidase were primarily active in haustorium development (T3), while xylanase, endo-glucanase, and peptidase were highly active in the haustorium penetration and xylem connection (T4). Patterns of auxins and cytokinin showed spatial concentrations in infective stages and moreover were involved in haustorium development. These results are the first evidence of proteins, cell wall-degrading enzymes, and phytohormones that are involved in early infection for the Psittacanthus genus, and thus represent a general infection mechanism for other mistletoe species. These results could help to understand the molecular dialogue in the establishment of P. calyculatus parasitism.

show abstract

“…The equations of the curves were used for quantitative calculation for each phenolic compound as follows: hydroxybenzoic acid was calculated as gallic acid equivalent and flavones as luteolin equivalent. The phenolic compounds were identified by comparing the retention time, UV-Vis absorption, and mass spectra with those of the standard compounds and with data from the specialized literature [21][22][23]. The quantification of phenolic compounds was done by using the calibration curve with gallic acid for hydroxybenzoic acid, respectively with luteolin for flavones [21,22,24].…”

Section: Chromatographic Conditionsmentioning

confidence: 99%

“…The phenolic compounds were identified by comparing the retention time, UV-Vis absorption, and mass spectra with those of the standard compounds and with data from the specialized literature [21][22][23]. The quantification of phenolic compounds was done by using the calibration curve with gallic acid for hydroxybenzoic acid, respectively with luteolin for flavones [21,22,24].…”

Section: Chromatographic Conditionsmentioning

confidence: 99%