Phytochemical profile and antioxidant activity of Dracocephalum moldavica L. seed extracts using different extraction methods

Song, Eunsu; Choi, Jae-Ho; Gwon, Hyeeun; Lee, Kyo-Yeon; Choi, Sung‐Gil; Islam, Md. Atiqual; Chun, Jiyeon; Hwang, Jae Ryoung

doi:10.1016/j.foodchem.2020.128531

Cited by 17 publications

(11 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Logo, a polaridade do solvente demonstra ser um fator de extrema importância no processo de extração de compostos vegetais, devido à discrepância entre os resultados de rendimento dos solventes mais polares dos mais apolares. Outros estudos também demonstram variação nos rendimentos de extratos brutos, de acordo com o tipo de solvente e parte da planta (VIEIRA et al, 2020;ZHAO et al, 2022), pois cada parte possui maior ou menor concentração de compostos hidrofóbicos ou hidrofílicos, como cascas, que costumam ser ricas em proteínas e carboidratos (GRABEZ et al, 2020;MAYASANKARAVALLI et al, 2020;SHEHATA et al, 2021), e as sementes, que possuem maior conteúdo lipídico (ABDALLA et al, 2021;SONG et al, 2021).…”

Section: Discussionunclassified

Avaliação De Diferentes Extratos Da Casca De Annona Squamosa Para Potencial Analgésico

et al. 2022

View full text Add to dashboard Cite

Plantas medicinais são cada vez mais investigadas no intuito de encontrar compostos de interesse biotecnológico. Nesse contexto, partes pouco utilizadas de plantas reportadas como medicinais são de alto interesse para bioprospecção e sustentabilidade. Pinha, Annona squamosa, é uma planta frutífera bem utilizada no Brasil e se enquadra nesse perfil. Com isso, o objetivo deste estudo foi comparar a extração de compostos da casca da pinha por diversos solventes e avaliar qual possui melhor atividade analgésica. Pinhas foram coletadas no município de Recife, PE, e o pó da casca foi submetido a extração por água, metanol, acetato de etila, clorofórmio e ciclohexano. Foi realizada triagem para identificação de vários metabólitos primários e secundários e foi realizado teste de analgésico para confirmação do potencial biológico. O rendimento foi de acordo com o grau de polaridade do extrato, extratos com maior polaridade apresentaram maior rendimento. Além disso, os extratos aquoso e metanólico apresentaram maior variedade de constituintes e maior potencial analgésico, pouco mais de 50 %. Água e Metanol se mostraram eficientes na extração de compostos de interesse medicinal da casca da pinha. Destes, a água é tida como o solvente de melhor escolha, tendo em vista o risco de toxicidade causada pelo metanol.

show abstract

Section: Discussionunclassified

Avaliação De Diferentes Extratos Da Casca De Annona Squamosa Para Potencial Analgésico

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Actually, total bioactive component content can affect the biological activities of plant extracts [ 24 ]. In the present study, radical scavenging (ABTS and DPPH), reducing power (FRAP, CUPRAC, and potassium ferricyanide), and phosphomolybdenum assays were applied to evaluate the antioxidant capacity of O. indicum .…”

Section: Discussionmentioning

confidence: 99%

“…When it comes to time consumption, cost, extraction efficiency, and environmental impact, each extraction method shows its own merits and drawbacks [21]. In addition, there are differences in the composition and content of bioactive substances in extracts obtained by different extraction processes, resulting in certain differences in biological activities [22][23][24]. In other words, the characteristics of extracts depend on the choice of extraction procedures [25].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Different Extraction Techniques on the Chemical Profile and Biological Properties of Oroxylum indicum: Multifunctional Aspects for Potential Pharmaceutical Applications

Yan¹,

Cheng

Bian

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Oroxylum indicum (L.) Kurz (Bignoniaceae), a traditional Chinese herbal medicine, possesses various biological activities including antioxidant, anti-inflammatory, antibacterial, and anticancer. In order to guide the practical application of O. indicum in the pharmaceutical, food, and cosmetic industries, we evaluated the effects of five different extraction techniques (maceration extraction (ME), oxhlet extraction (SOXE), ultrasound-assisted extraction (UAE), tissue-smashing extraction (TSE), and accelerated-solvent extraction (ASE)) with 70% ethanol as the solvent on the phytochemical properties and biological potential. The UHPLC-DAD Orbitrap Elite MS technique was applied to characterize the main flavonoids in the extracts. Simultaneously, the antioxidant and enzyme inhibitory activities of the tested extracts were analyzed. SOXE extract showed the highest total phenolic content (TPC, 50.99 ± 1.78 mg GAE/g extract), while ASE extract displayed the highest total flavonoid content (TFC, 34.92 ± 0.38 mg RE/g extract), which displayed significant correlation with antioxidant activity. The extract obtained using UAE was the most potent inhibitor of tyrosinase (IC50: 16.57 ± 0.53 mg·mL−1), while SOXE extract showed the highest activity against α-glucosidase (IC50: 1.23 ± 0.09 mg·mL−1), succeeded by UAE, ME, ASE, and TSE extract. In addition, multivariate analysis suggested that different extraction techniques could significantly affect the phytochemical properties and biological activities of O. indicum. To sum up, O. indicum displayed expected biological potential and the data collected in this study could provide an experimental basis for further investigation in practical applications.

show abstract

“…Polyphenols have the same average reduction potential as vitamin E and are considered to be the richest antioxidants in the daily diet [ 20 , 21 ]. The biological activity depends on chemical structure, including the hydroxylation position of a single compound and the substitution of specific hydroxyl groups.…”

Section: Polyphenol Anti-gc Mechanismmentioning

confidence: 99%

Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review

Zheng

Zhao

et al. 2022

Current Oncology

View full text Add to dashboard Cite

The lack of new drugs and resistance to existing drugs are serious problems in gastric cancer(GC) treatment. The research found polyphenols possess anti-Helicobacter pylori(Hp) and antitumor activities and may be used in the research and development of drugs for cancer prevention and treatment. However, polyphenols are affected by their chemical structures and physical properties, which leads to relatively low bioavailability and bioactivity in vivo. The intestinal flora can improve the absorption, utilization, and biological activity of polyphenols, whereas polyphenol compounds can increase the richness of the intestinal flora, reduce the activity of carcinogenic bacteria, stabilize the proportion of core flora, and maintain homeostasis of the intestinal microenvironment. Our review summarizes the gastrointestinal flora-mediated mechanisms of polyphenol against GC.

show abstract

Phytochemical profile and antioxidant activity of Dracocephalum moldavica L. seed extracts using different extraction methods

Cited by 17 publications

References 36 publications

Avaliação De Diferentes Extratos Da Casca De Annona Squamosa Para Potencial Analgésico

Avaliação De Diferentes Extratos Da Casca De Annona Squamosa Para Potencial Analgésico

The Influence of Different Extraction Techniques on the Chemical Profile and Biological Properties of Oroxylum indicum: Multifunctional Aspects for Potential Pharmaceutical Applications

Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review

Contact Info

Product

Resources

About