Phytochemical, pharmacological and ethnobotany study of some Congolese plants with potential anticonvulsant

Bassoueka, D’Avila Judicaelle; Loufoua, B. A. E.; Etou-Ossibi, A. W.; Nsondé-Ntandou, G. F.; Ondélé, R; Elion-Itou, R. D. G.; Ouamba, J. M.; Abena, Ange Antoine

doi:10.1007/s10298-015-0979-2

Cited by 9 publications

(3 citation statements)

References 5 publications

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“…Epilepsy is a corporate neurological disorder accompanied by persistent motive- https://doi.org/10.4236/jbm.2022.1012003 Journal of Biosciences and Medicines less seizures [1] [2] [3]. About 5% of the world population improves epilepsy in their lifetime while the global occurrence rate of epilepsy in Congo is 4.67 per 500 habitats [4]. Presently, various synthetic drugs like carbamazepine, ethosuximide, gabapentin, oxcarbazepine, phenobarbital, phenytoin, valproic acid, felbamate are used as effective antiepileptic agents; however, they remain not free from noticeable side effects.…”

Section: Introductionmentioning

confidence: 99%

Anticonvulsant, Sedative and Antidepressant Effects of Aqueous Extract of <i>Costus afer</i> Stems in Mice

Judicaël¹,

Lazard²,

Radar³

et al. 2022

JBM

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Epilepsy is a disorder in the nervous system which often causes a loss of consciousness. Traditional treatments are quiet a component of health care system in various populations in spite of the fact that well-established options are available. Most plants are used to treat epilepsy or those which have been verified for anticonvulsant activity were reported. Then, Costus afer is a plant of the Congolese flora used in traditional medicine for its many virtues.Therefore, the anticonvulsant activity of Costus afer was assessed with the strychnine convulsion induction test. Two tests were used for sedative activity such as the barbiturate sleep induction test and motor activity and finally the forced swimming test was also used to assess antidepressant activity. The results showed that the aqueous extract of Costus afer stems had no effects on strychnine-induced seizures at doses of 250 mg/kg and 500 mg/kg compared to the control group. However, the extract of Costus afer stems caused a very significant decrease in motricity at a dose of 500 mg/kg, showing a decrease in the onset time and a very significant increase in sleep duration like the reference molecule such as Diazepam. The aqueous extract of Costus afer stems also caused a decrease in immobility time in mice at a dose of 500 mg/kg.

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Section: Introductionmentioning

confidence: 99%

Anticonvulsant, Sedative and Antidepressant Effects of Aqueous Extract of <i>Costus afer</i> Stems in Mice

Judicaël¹,

Lazard²,

Radar³

et al. 2022

JBM

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“…The species contains a wide range of chemotypes with different bioactivities and organoleptic profiles. Several studies have demonstrated its sedative, anticonvulsive, anti-infectious, antiparasitic, and antitussive properties [ 31 , 32 , 33 , 34 , 35 , 36 ]. It has analgesic, antipyretic and anti-inflammatory proprieties [ 30 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antibacterial Activity of Lippia multiflora Moldenke Essential Oil from Different Regions of Angola

et al. 2020

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The purpose of the study was to determine the chemical composition and antibacterial activity of Lippia multiflora Moldenke essential oils (EOs) collected in different regions of Angola. Antibacterial activity was evaluated using the agar wells technique and vapour phase test. Analysis of the oils by GC/MS identified thirty-five components representing 67.5 to 100% of the total oils. Monoterpene hydrocarbons were the most prevalent compounds, followed by oxygenated monoterpenes. The content of the compounds varied according to the samples. The main components were Limonene, Piperitenone, Neral, Citral, Elemol, p-cymene, Transtagetone, and Artemisia ketone. Only one of the eleven samples contained Verbenone as the majority compound. In the vapour phase test, a single oil was the most effective against all the pathogens studied. The principal component analysis (PCA) and hierarchical cluster analysis (HCA) of components of the selected EOs and inhibition zone diameter values of agar wells technique allowed us to identify a variability between the plants from the two provinces, but also intraspecific variability between sub-groups within a population. Each group of essential oils constituted a chemotype responsible for their bacterial inhibition capacity. The results presented here suggest that Angolan Lippia multiflora Moldenke has antibacterial properties and could be a potential source of antimicrobial agents for the pharmaceutical and food industry.

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“…Medicinal plants are thought to be effective and safer with less side effects and also available to the common population in the underdeveloped and developing countries in the world. Due to the therapeutic nature of natural products, medicinal plants are being used as antidiabetic [9], antimicrobial [10,11], antitrypanosomal [12], antibacterial [13], antimalarial [14], antioxidant [15], anticonvulsant [16], and antihypertensive activities [17].…”

Section: Introductionmentioning

confidence: 99%

Isolation and characterization of spinasterol from crossopterxy febrifuga stem bark

Khan

Adeiza

Tor-Anyiin

et al. 2019

Prog. Chem. Biochem. Res.

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Phytochemical, pharmacological and ethnobotany study of some Congolese plants with potential anticonvulsant

Cited by 9 publications

References 5 publications

Anticonvulsant, Sedative and Antidepressant Effects of Aqueous Extract of <i>Costus afer</i> Stems in Mice

Anticonvulsant, Sedative and Antidepressant Effects of Aqueous Extract of <i>Costus afer</i> Stems in Mice

Chemical Composition and Antibacterial Activity of Lippia multiflora Moldenke Essential Oil from Different Regions of Angola

Isolation and characterization of spinasterol from crossopterxy febrifuga stem bark

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Phytochemical, pharmacological and ethnobotany study of some Congolese plants with potential anticonvulsant

Cited by 9 publications

References 5 publications

Anticonvulsant, Sedative and Antidepressant Effects of Aqueous Extract of &lt;i&gt;Costus afer&lt;/i&gt; Stems in Mice

Anticonvulsant, Sedative and Antidepressant Effects of Aqueous Extract of &lt;i&gt;Costus afer&lt;/i&gt; Stems in Mice

Chemical Composition and Antibacterial Activity of Lippia multiflora Moldenke Essential Oil from Different Regions of Angola

Isolation and characterization of spinasterol from crossopterxy febrifuga stem bark

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Product

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Anticonvulsant, Sedative and Antidepressant Effects of Aqueous Extract of <i>Costus afer</i> Stems in Mice

Anticonvulsant, Sedative and Antidepressant Effects of Aqueous Extract of <i>Costus afer</i> Stems in Mice