Phytochemical‐mediated modulation of autophagy and endoplasmic reticulum stress as a cancer therapeutic approach
Mazoun Al Azzani,
Zohra Nausheen Nizami,
Rym Magramane
et al.
Abstract:Autophagy and endoplasmic reticulum (ER) stress are conserved processes that generally promote survival, but can induce cell death when physiological thresholds are crossed. The pro‐survival aspects of these processes are exploited by cancer cells for tumor development and progression. Therefore, anticancer drugs targeting autophagy or ER stress to induce cell death and/or block the pro‐survival aspects are being investigated extensively. Consistently, several phytochemicals have been reported to exert their a… Show more
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