Phytochemical Loaded Nanovehicles of Biopolymer for Breast Cancer: A Systemic Review

Chavda, Vivek P.; Vuppu, Suneetha; Bezbaruah, Rajashri; Nalla, Lakshmi Vineela; Gajula, Siva Nageswara Rao; Balar, Pankti C.; Mishra, Toshika; Sharma, Nikita; Kamaraj, Sathvika; Suresh, Thushar; Sairam, Anand; Bhattacharjee, Bedanta

doi:10.1016/j.ccmp.2023.100114

Cited by 4 publications

(3 citation statements)

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“…The efficacy however, can be reduced attributed to their low bioavailability on oral consumption and low solubility in water (Koklesova et al, 2023). The encapsulation of the phytochemicals in nanostructures enhances its efficacy by promoting targeted delivery to the specific location in the human body (Chavda et al, 2023).…”

Section: Phytochemical-loaded Nanoparticlesmentioning

confidence: 99%

“…The nanoformulations of phytocompounds can be developed using common nanoparticle carriers like micelles, polymeric dendrimers, nanoemulsions, metallic nanoparticles and liposomes. The nanoparticle carriers also protect by pharmaceutic molecule from the external environment providing extended systemic circulation (Chavda et al, 2023). The combination of nanoparticles with phytocompounds results in improved antimicrobial activity due to enhanced mechanical, biopharmaceutical, physicochemical, morphological, release and bioavailability characteristics.…”

Section: Phytochemical-loaded Nanoparticles In Covid-19mentioning

confidence: 99%

“…This approach can also be utilized against antibiotic resistant bacteria (Díaz-Puertas et al, 2023). The domain of nanotechnology has transformed management of infectious and non-infectious diseases by facilitating targeted drug release improving the health of patients (Chavda et al, 2023).…”

Section: Phytochemical-loaded Nanoparticles In Covid-19mentioning

confidence: 99%

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Phytochemical-loaded Nanoparticles in COVID-19 Management

Vuppu,

Mishra,

Mishra

et al. 2023

NRFHH

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A phytochemical-loaded nanoparticle is an important therapeutic agent that aids in enhancing the bioavailability of phytochemicals of lower water solubility and delivering the phytochemicals to the site of infection in a targeted manner. This strategy has also been developed for the management of COVID-19. They can be used as antiviral medication carriers, causing the direct death of viral particles and imitating the host in order to neutralize viral processes. In the formulation of phytochemical-loaded nanoparticles against SARS-CoV-2, different categories of nanoparticles, including inorganic, lipid-based, and polymeric nanoparticles, are used. Numerous phytochemicals belonging to the classes of alkaloids, flavonoids, terpenes, terpenoids, saponins, glycosides, polyphenols, and lignans, that demonstrate effective antiviral properties are utilized for the phytochemical-loaded nanoparticles. This approach results in increased solubility and stability of the phytochemicals with lower systemic toxicity, in addition to site-specific delivery. The combination therapy delivers multiple therapeutic agents at the site of infection. It can also be administered directly to the respiratory system by inhalation delivery. Therefore, this approach can potentially inhibit the application of phytochemical-loaded nanoparticles for the treatment of COVID-19, which is still in its replication of the SARS-CoV-2 virus and reduces the severity of the disease. The infancy and a number of obstacles must be overcome prior to their widespread use.

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Section: Phytochemical-loaded Nanoparticlesmentioning

confidence: 99%

Section: Phytochemical-loaded Nanoparticles In Covid-19mentioning

confidence: 99%