Phytochemical investigations of Atraphaxis spinosa L (Polygonaceae)

Wang, Xinhui; Khutsishvili, Manana; Fayvush, George; Tamanyan, Kamilla; Atha, Daniel; Borris, Robert P.

doi:10.1016/j.bse.2018.02.001

Cited by 10 publications

(8 citation statements)

References 20 publications

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“…Certain Atraphaxis species produce essential oils that contain volatile compounds responsible for the characteristic aroma of the plant. These essential oils may have various uses, including in traditional medicine and as flavoring agents [ 37 ]. Phenolic acids, such as caffeic acid and ferulic acid, have been detected in Atraphaxis species.…”

Section: Bioactive Compounds From Four Atraphaxis ...mentioning

confidence: 99%

“…These compounds were characterized as N-trans-p-coumaroyl-3′,4′-dihydroxyphenylethylamine, N-trans-feruloyl-3′,4′-dihydroxyphenylethylamine, (−)-fisetinidol, (−)-catechin, butin, quercetin, quercetin-3-methyl ether, 5-deoxykaempferol, and β-sitosterol glucoside. The compounds N-trans-p-coumaroyl-3′,4′-dihydroxyphenylethylamine and N-trans-feruloyl-3′,4′-dihydroxyphenylethylamine, which were isolated from natural sources for the first time, exhibited cytotoxic effects on leukemic P388 cells [ 34 , 36 , 37 ].…”

Section: Bioactive Compounds From Four Atraphaxis ...mentioning

confidence: 99%

“…Flavonoids, specifically flavonol glycosides, such as myricitrin, have been identified in A. frutescens [ 35 ] and A. spinosa L. [ 37 ]. Myricitrin exhibits noteworthy antioxidant properties and showcases anti-inflammatory as well as anti-nociceptive effects [ 78 ].…”

Section: Bioactive Compounds From Four Atraphaxis ...mentioning

confidence: 99%

“…Phytochemical investigations of Atraphaxis species have unveiled the existence of diverse bioactive compounds, although the precise phytochemical composition can differ among various species and even within the same species [ 35 , 36 , 37 , 38 ]. Some of the typical phytochemicals identified in Atraphaxis species encompass polyphenols, triterpenoids, alkaloids, essential oils, phenolic acids, saponins, and lignans.…”

Section: Introductionmentioning

confidence: 99%

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Exploring Four Atraphaxis Species: Traditional Medicinal Uses, Phytochemistry, and Pharmacological Activities

Abilkassymova,

Turgumbayeva,

Sarsenova

et al. 2024

Molecules

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Atraphaxis is a genus of flowering plants in the family Polygonaceae, with approximately 60 species. Species of Atraphaxis are much-branched woody plants, forming shrubs or shrubby tufts, primarily inhabiting arid zones across the temperate steppe and desert regions of Central Asia, America, and Australia. Atraphaxis species have been used by diverse groups of people all over the world for the treatment of various diseases. However, their biologically active compounds with therapeutic properties have not been investigated well. Studying the biologically active components of Atraphaxis laetevirens, Atraphaxis frutescens, Atraphaxis spinosa L., and Atraphaxis pyrifolia is crucial for several reasons. Firstly, it can unveil the therapeutic potential of these plants, aiding in the development of novel medicines or natural remedies for various health conditions. Understanding their bioactive compounds enables scientists to explore their pharmacological properties, potentially leading to the discovery of new drugs or treatments. Additionally, investigating these components contributes to preserving traditional knowledge and validating the historical uses of these plants in ethnomedicine, thus supporting their conservation and sustainable utilization. These herbs have been used as an anti-inflammatory and hypertension remedies since the dawn of time. Moreover, they have been used to treat a variety of gastrointestinal disorders and problems related to skin in traditional Kazakh medicine. Hence, the genus Atraphaxis can be considered as a potential medicinal plant source that is very rich in biologically active compounds that may exhibit great pharmacological properties, such as antioxidant, antibacterial, antiulcer, hypoglycemic, wound healing, neuroprotective, antidiabetic, and so on. This study aims to provide a collection of publications on the species of Atraphaxis, along with a critical review of the literature data. This review will constitute support for further investigations on the pharmacological activity of these medicinal plant species.

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Section: Bioactive Compounds From Four Atraphaxis ...mentioning

confidence: 99%

Section: Bioactive Compounds From Four Atraphaxis ...mentioning

confidence: 99%

Section: Bioactive Compounds From Four Atraphaxis ...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Exploring Four Atraphaxis Species: Traditional Medicinal Uses, Phytochemistry, and Pharmacological Activities

Abilkassymova,

Turgumbayeva,

Sarsenova

et al. 2024

Molecules

View full text Add to dashboard Cite

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“…Earlier phytochemical studies on the genus Atraphaxis have shown that this genus is rich in various types of chemical components, including phenylpropanoids, flavonoids, anthraquinones, sterols, benzenoids, tannins and phenolic compounds [ 9 ]. Flavonoid glycosides have been found to be the major components of Atraphaxis species [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Micro-Morphological Characterization of Atraphaxis pyrifolia Bunge Growing in the Republic of Kazakhstan

Abilkassymova,

Kozykeyeva,

Aldana-Mejía

et al. 2024

Molecules

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Atraphaxis pyrifolia is a native species of Central Asia, known for curing several disorders. The species has little knowledges about its chemical composition and any information about its morphological characteristics despite its importance in traditional Asian medicine. This is one of the first approaches to the phytochemical and morphological characterization of this species. Micro-morphology was performed on the stem, and leaf parts of this plant to profile the morpho-anatomical characters using brightfield, fluorescence, polarized and scanning electron microscopy. Leaves were extracted with hexane and methanol. The hexane extract was analyzed using GC-MS analysis revealing the major presence of γ-sitosterol and nonacosane. The methanolic extract was submitted to Vacuum Liquid Chromatography and Sephadex LH-20. HPTLC, HR-ESI-MS and NMR techniques were used to identify the main compounds. Four glycosylated flavonoids were isolated: 8-O-acetyl-7-O-methyl-3-O-α-l-rhamnopyranosylgossypetin (Compound 1), and 7-O-methyl-3-O-α-l-rhamnopyranosylgossypetin (Compound 3), and two other compounds reported for the first time in the literature (Compounds 2 and 4). The findings presented herein furnish pertinent information essential for the identification and authentication of this medicinal plant. Such insights are invaluable for facilitating robust quality control measures and serve as a foundational framework for subsequent endeavours in metabolic, pharmacological, and taxonomical analyses.

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Chemical Constituents of the Fruits of Cornus Officinalis and Evaluation of their Neuroprotective Activity

Yang,

Hao,

Wang

et al. 2024

Chemistry & Biodiversity

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The phytochemical investigation of the fruits of Cornus officinalis yielded a new phenolic acid derivative, neophenolic acid A (1), and a novel flavonoid glycoside, (2R)‐naringenin‐7‐O‐β‐(6″‐galloyl‐glucopyranoside) (2a), along with six known flavonoid glycosides (2b – 7). Their structures were determined by 1D, 2D NMR and HRESIMS data. The absolute configuration of 1 was established by ECD analysis. Compounds 1 – 7 were evaluated for their neuroprotective activities against corticosterone (CORT)‐induced injury in PC‐12 cells. Compounds 1, 2a, 2b, 5, and 6 exhibited neuroprotective activities against CORT‐induced neurotoxicity in PC‐12 cells. The underlying mechanism study suggested that compounds 1, 2a, 2b, 5, and 6 were able to attenuate CORT‐induced apoptosis and damage, increase the levels of MMP and decrease Ca2+ inward flow in PC‐12 cells.

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Phytochemical investigations of Atraphaxis spinosa L (Polygonaceae)

Cited by 10 publications

References 20 publications

Exploring Four Atraphaxis Species: Traditional Medicinal Uses, Phytochemistry, and Pharmacological Activities

Exploring Four Atraphaxis Species: Traditional Medicinal Uses, Phytochemistry, and Pharmacological Activities

Phytochemical and Micro-Morphological Characterization of Atraphaxis pyrifolia Bunge Growing in the Republic of Kazakhstan

Chemical Constituents of the Fruits of Cornus Officinalis and Evaluation of their Neuroprotective Activity

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