Phytochemical investigation of labdane diterpenes from the rhizomes of Hedychium spicatum and their cytotoxic activity

Reddy, P. Prabhakar; Rao, R. Ranga; Shashidhar, J.; Sastry, B. S.; Rao, J. Madhusudana; Babu, K. Suresh

doi:10.1016/j.bmcl.2009.09.032

Cited by 42 publications

(5 citation statements)

References 15 publications

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“…[1] The plant has also been evaluated for its cytotoxic activity by Reddy et al . [2] The survey published by Akhtar et al . reported the use of H. spichatum as an anthelmintic in the Indian–Pakistan region.…”

Section: Introductionmentioning

confidence: 99%

An in vitro evaluation of the anthelmintic activity of Hedychium spichatum rhizomes and Zingiber zerumbet rhizomes on the Pheritima Posthuma model: A comparative study

Goswami¹,

Awanish²,

Tripathi³

et al. 2011

Phcog Res

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Ethanolic extracts of Hedychium spichatum rhizomes and Zingiber zerumbet rhizomes were taken for in vitro comparative studies on the anthelmintic activity against Pheritima posthuma. Different concentrations (25, 50, 100 mg/ml) of both the extracts were used for the activity. Varying albendazole concentrations (25, 50, 100 mg/ml) were used as a reference standard and normal saline (0.9% NaCl) was used for the control treatment. The results were expressed in terms of time in minutes to report the paralysis and time of death of the earthworms. The results obtained from the study indicate toward the anthelmintic activity, supporting folk use of both the plants when compared with the standard. The results also established that Z. zerumbet was a more potent candidature of as compared with H. spichatum.

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Section: Introductionmentioning

confidence: 99%

An in vitro evaluation of the anthelmintic activity of Hedychium spichatum rhizomes and Zingiber zerumbet rhizomes on the Pheritima Posthuma model: A comparative study

Goswami¹,

Awanish²,

Tripathi³

et al. 2011

Phcog Res

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“…According to previous studies, the coronarin E, as the most predominant constituent in H. flavum EO, had higher cytotoxicity to human tumor cell lines (NCI-H187, HL-60, THP-1, and A-549) (IC 50 : 31.21-53.26 mM) compared to noncancerous Vero cell (IC 50 : 150.45 mM), with selective cytotoxicity against tumor cells (Reddy et al, 2009;Kumrit et al, 2010). The cytotoxic properties of other main components in EO, such as 1,8cineole, b-pinene, a-pinene, E-nerolidol, linalool, and acurcumene, have been demonstrated in previous reports (Hassan et al, 2010;Shin and Lee, 2013;Dall'Acqua et al, 2017;Salehi et al, 2019).…”

Section: Cytotoxic Activitymentioning

confidence: 86%

Phytochemical Analysis, Antioxidant, Antibacterial, Cytotoxic, and Enzyme Inhibitory Activities of Hedychium flavum Rhizome

Tian

et al. 2020

Front. Pharmacol.

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“…Dichloromethane and methanol (1:1) solvent was used to extract the Hedychium spicatum rhizome. Chrysin was isolated in an ethyl acetate/ether/hexane (25:14:61) fraction of silica gel (100–200 mesh) column chromatography [ 22 ]. Chloroform extract of the Hedychium spicatum rhizome was chromatographed over silica gel (60–120 mesh), and Teptochrysin containing fraction F2 was further purified by column chromatography over silica gel (100–200 mesh) using Methanol:Chloroform (7:93) solvent, and was characterized by IR, MS, 1D and 2D NMR [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

A Comprehensive Review on Pharmacologically Active Phyto-Constituents from Hedychium species

et al. 2023

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In this review, we describe and discuss the phytoconstituents present in Hedychium species and emphasize their potential as drug candidates. Though they are widely validated in vitro and in vivo models, to date, no efforts have been made to compile in a single review all the pharmacologically active phytoconstituents from Hedychium species, and their pharmacological and toxicity profile. In this study, we present a reinvestigation of the chemical constituents present in Hedychium species obtained from the essential oil and solvent extraction of the flowers, leaves and rhizomes under consideration. Key databases such as PubMed, Science Direct, Scopus, and Google Scholar amongst others were probed for a systematic search using keywords to retrieve relevant publications on this plant. An exhaustive electronic survey of the related literature on Hedychium species resulted in around 200 articles. Articles published between the years 1975–2021 were included. The studies conducted on either crude extracts, solvent fractions or isolated pure compounds from Hedychium species reported with a varied range of biological effects such as anti-inflammatory, analgesic, antidiabetic, potentially anti-asthmatic, and cytotoxic, among other related activities of the chemical constituents present in its essential oil and solvent extract deployed in this review. Traditional and herbal medication around the world that uses different parts of Hedychium species were considered for anti-inflammatory, skincare, analgesic, anti-asthmatic, anti-diabetic, antidotal uses, among others. These uses support the idea that chemical constituents obtained from solvent extraction may also exert the same action individually or in a synergistic manner. The review concluded that there is scope for computation and biological study to find out possible new targets for strengthening the potency and selectivity of the relevant compounds, and to find a commercial method for extraction of active pharmaceutical ingredients.

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Phytochemical investigation of labdane diterpenes from the rhizomes of Hedychium spicatum and their cytotoxic activity

Cited by 42 publications

References 15 publications

An in vitro evaluation of the anthelmintic activity of Hedychium spichatum rhizomes and Zingiber zerumbet rhizomes on the Pheritima Posthuma model: A comparative study

An in vitro evaluation of the anthelmintic activity of Hedychium spichatum rhizomes and Zingiber zerumbet rhizomes on the Pheritima Posthuma model: A comparative study

Phytochemical Analysis, Antioxidant, Antibacterial, Cytotoxic, and Enzyme Inhibitory Activities of Hedychium flavum Rhizome

A Comprehensive Review on Pharmacologically Active Phyto-Constituents from Hedychium species

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