Phytochemical Investigation of <i>Annulohypoxylon ilanense</i>, an Endophytic Fungus Derived from <i>Cinnamomum</i> Species

Wu, Ming-Der; Cheng, Ming‐Jen; Chen, Ih-Sheng; Su, Ying-Jhen; Hsieh, Sung‐Yuan; Chang, Hung‐Chun; Chang, Chun‐Wei; Yuan, Gwo‐Fang

doi:10.1002/cbdv.201200418

Cited by 21 publications

(9 citation statements)

References 58 publications

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“…Within this category, loliolide (Figure 1), first characterized from Lolium perenne [100], has been reported from a strain of Annulohypoxylon ilanense from the wood of a plant of Cinnamomum sp. [101]. Xanthatin (Figure 1), first isolated from cockleburs (Xanthium spp.)…”

Section: Other Terpenoidsmentioning

confidence: 99%

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

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Abstract:It is known that plant-based ethnomedicine represented the foundation of modern pharmacology and that many pharmaceuticals are derived from compounds occurring in plant extracts. This track still stimulates a worldwide investigational activity aimed at identifying novel bioactive products of plant origin. However, the discovery that endophytic fungi are able to produce many plant-derived drugs has disclosed new horizons for their availability and production on a large scale by the pharmaceutical industry. In fact, following the path traced by the blockbuster drug taxol, an increasing number of valuable compounds originally characterized as secondary metabolites of plant species belonging to the Spermatophyta have been reported as fermentation products of endophytic fungal strains. Aspects concerning sources and bioactive properties of these compounds are reviewed in this paper.

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Section: Other Terpenoidsmentioning

confidence: 99%

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

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“…Annulohypoxylon ilanense , an endophytic fungus, has been isolated from the wood of Cinnamon species (Wu et al . 2013). In the present study, Annulohypoxylon sp.…”

Section: Resultsmentioning

confidence: 99%

Fungal pretreatment to enhance the yield of phytochemicals and evaluation of α‐amylase and α‐glucosidase inhibition usingCinnamomum zeylanicum(L.) quills pressurized water extracts

Wariyapperuma

Kannangara

Wijayasinghe

et al. 2020

Lett Appl Microbiol

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Bioactive compounds entrapped in plant materials can be effectively recovered using fungal enzymes. Cinnamomum zeylanicum Sri Wijaya (SW) and Sri Gemunu (SG) accessions and commercially available C. zeylanicum (CC) were subjected to fungal pretreatment and extracted with pressured water (PWE, 0·098 MPa). Thirteen fungal species were isolated and the substrate utilization ability of the species was tested using cellulose, pectin and lignin (indirectly). Total phenolic content (TPC, Folin–Ciocalteu method), proanthocyanidin content (PC, vanillin method) and α‐amylase and α‐glucosidase inhibitory potential of the extracts were evaluated. The anti‐diabetic drug, Acarbose was used as the positive control. Trichoderma harzianum (MH298760) showed the highest cell lysis ability and hence was used for the microbial pretreatment process. Extracts of SW treated with T. harzianum species (Pre‐SW) gave the highest percentage yield (4·08% ± 0·15%), significantly potent inhibition (P < 0·05) of α‐amylase and α‐glucosidase activities (IC50 57 ± 8 and 36 ± 8 μg ml−1 respectively), TPC (2·24 ± 0·02 mg gallic acid equivalent g−1), and PC (48·2 ± 0·4 mg of catechin equivalent g−1) compared to Pre‐SG, Pre‐CC and nontreated samples. Trichoderma harzianum treatment can enhance the hypoglycaemic properties, PC and TPC of Cinnamon extracts and provide new insights into the recovery of phytochemicals.

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“…15 Cinnamomum mercadoi (Lauraceae) is a tree endemic to the Philippines. It is traditionally used as expectorant and for the treatment of digestion problem and tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Endophytic Fungi Isolated from the Bark of Cinnamomum mercadoi

Marcellano¹,

Collanto²,

Fuentes³

2017

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Introduction: Cinnamomum mercadoi is a medicinal tree endemic to the Philippines. Cinnamomum species have been extensively studied for their endophytic fungi with pharma cological importance. This study aims to isolate and evaluate the antibacterial activity of endophytic fungi associated with the bark of C. mercadoi. Materials and Methods: Endophytic fungi were isolated from surface sterilized bark samples aseptically. The pure isolates were identified through their morphological characteristics. Agar plug diffusion assay was employed in the primary screening of their antibacterial activity against Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. Four active endophytes were fermented and extracted with ethyl acetate (EtOAc). The antibacterial activity of the EtOAc extracts was screened using the disk diffusion assay. The minimum inhibitory activity (MIC) was evaluated using the microdilution method. Results: Twelve (12) endophytes were isolated from the bark of C. mercadoi. All endophytes exhibited antibacterial activity on at least one of the test pathogens. However, only two of the four endophytes subjected to the secondary screening showed wide-spectrum activity and inhibited the growth of all test bacteria. Fusarium sp. 2 was identified to have the most promising activity with MIC values ranging from 2.1 -4.2 mg/mL. Conclusion: C. mercadoi harbors endophytes, particularly Fusarium sp. 2, which possess antibacterial activity and thus a potential source of antibacterial compounds. endophytic fungi, particularly those isolated from medicinal plants for their potential as source of new antibiotics. [8][9][10] Several Cinnamomum species has been studied for their associated endophytes because of their promising antibacterial activity.11-13 Moreover, active compounds have been isolated from endophytic fungi associated with this species. Cinnamomum zeylanicum, collected from Honduras, was the host of a novel endophyte Muscador albus which was reported to contain volatile organic compounds with antimicrobial activities.14 Antimycobacterial compounds were isolated from Annulohypoxylon ilanense, an endophyte of a Cinnamomum species from Taiwan. 15 Cinnamomum mercadoi (Lauraceae) is a tree endemic to the Philippines. It is traditionally used as expectorant and for the treatment of digestion problem and tuberculosis. 16,17 Biological studies of C. mercadoi had shown that its crude extract exhibited analgesic, antimicrobial, antioxidant and antidiarrheal properties. [17][18][19] No previous study on its endophytic fungi has been reported to the best of our knowledge. In this study, we have isolated 12 endophytic fungi and screened them for their antibacterial activity. An Ascomycete isolate, Fusarium sp. 2, is being reported to have a broad spectrum and promising antibacterial activity. MATERIALS AND METHODS Sample CollectionBark samples were collected from a healthy Cinnamomum mercadoi tree in Barangay Patag, Baybay, Leyte, Philippines (10.74 °N, 124.79°E,31.5 m elevation) i...

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Phytochemical Investigation of Annulohypoxylon ilanense, an Endophytic Fungus Derived from Cinnamomum Species

Cited by 21 publications

References 58 publications

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Fungal pretreatment to enhance the yield of phytochemicals and evaluation of α‐amylase and α‐glucosidase inhibition usingCinnamomum zeylanicum(L.) quills pressurized water extracts

Antibacterial Activity of Endophytic Fungi Isolated from the Bark of Cinnamomum mercadoi

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