Phytochemical, cytotoxic, hepatoprotective and antioxidant properties of Delonix regia leaves extract

Azab, Samar S.; Abdel-Daim, Mohamed M.; Eldahshan, Omayma A.

doi:10.1007/s00044-012-0420-4

Cited by 69 publications

(38 citation statements)

References 24 publications

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“…Herbal plants and plant-derived drugs have been widely used in traditional cultures everywhere in the world and have gained popularity in modern society as natural alternatives to produce new potential therapeutic agents for combating diseases Azab et al 2013;Madkour and AbdelDaim 2013). For example, 60 % of the current available anticancer agents derived from natural products.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical study, cytotoxic, analgesic, antipyretic and anti-inflammatory activities of Strychnos nux-vomica

Eldahshan

Abdel-Daim

2014

Cytotechnology

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The strychnine tree (Strychnos nux-vomica L.) (S. nux-vomica) belonging to family Loganiaceae has been a very promising medication for certain disorders. Different chromatographic methods were used to isolate the phenolic compounds from the aqueous methanolic extract of the S. nux-vomica leaves. Their identification was achieved through spectroscopic techniques. Cytotoxicity, analgesic, antipyretic and anti-inflammatory activities of S. nuxvomica leaves extract were evaluated. Five phenolic compounds were isolated and identified; Kaempferol-7 glucoside 1, 7-Hydroxy coumarin 2, Quercetin-3-rhamnoside 3, Kaempferol 3-rutinoside 4, and Rutin 5. Furthermore, the cytotoxic activity of the extract was evaluated against different cancer cell lines. The extract showed potential cytotoxic activity against human epidermoid larynx carcinoma cells (Hep-2) and against breast carcinoma cell line (MCF-7). Colon carcinoma cells (HCT) were the least one affected by the extract. In addition, the extract exhibited promising analgesic, antipyretic as well as anti-inflammatory activities. It is concluded that, leaves extract of S. nux vomica possess potent cytotoxic, analgesic, antipyretic and anti-inflammatory activities. These activities could be due to the presence of phenolic compounds revealed by our phytochemical investigations.

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Section: Discussionmentioning

confidence: 99%

Phytochemical study, cytotoxic, analgesic, antipyretic and anti-inflammatory activities of Strychnos nux-vomica

Eldahshan

Abdel-Daim

2014

Cytotechnology

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“…The cells overcome oxidative stress by either removal of the damaged nucleotides and products of the lipid peroxidation or directly scavenging free radicals via endogenous enzymatic and non-enzymatic antioxidants (Madkour and Abdel-Daim 2013;Abdel-Daim et al 2013;Azab et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

Abdel-Daim

2014

Cytotechnology

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Diazinon (DZN) is a synthetic organophosphrus acaricide and insecticide widely used for veterinary and agricultural purposes. However, its animal and human exposure leads to nephrotoxicity. Our experimental objective was to evaluate protective effects of ceftriaxone and/or ascorbic acid-vitamin C against DZN-induced renal injury in male Wistar albino rats. DZN-treated animals revealed significant elevation in serum biochemical parameters related to renal injury: urea, uric acid and creatinine. DZN intoxication significantly increased renal lipid peroxidation, and significant inhibition in antioxidant biomarkers including, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase and total antioxidant capacity. In addition, DZN significantly reduced serum acetylcholinestrase level. Moreover, It induced serum and kidney tumor necrosis factor-a level. Both ceftriaxone and vitamin C protect against DZN-induced serum as well as renal tissue biochemical parameters when used alone or in combination along with DZN-intoxication. Furthermore, both ceftriaxone and vitamin C produced synergetic nephroprotective and antioxidant effects. Therefore, it could be concluded that ceftriaxone and/or vitamin C administration are able to minimize the toxic effects of DZN by its free radical-scavenging and potent antioxidant activity.

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“…once daily once daily of hydroalcoholic extract. 13 n-hexane, ethyl acetate and remaining aqueous fractions groups; rats received 100 mg/kg p.o. once daily of each extract separately.…”

Section: Hepatoprotective Assaymentioning

confidence: 99%

“…13,7 Thus, the present study was done with three aims concerning Delonix regia; a pharmacognostical discription of the plant organs, total phenolic and flavonoid contents determination and HPLC profiling using RP-HPLC-UV, and to evaluate possible hepatoprotective activity of a hydroalcoholic leaves extract and its fractions to justify its use as a natural chemopreventive agents.…”

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Pharmacognostical and Biological Studies of Delonix regia growing in Egypt: HPLC Profiles

El-gizawy¹,

Alazzouni²,

El-Haddad³

2018

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Background: Delonix regia (Hook.) Raf. (Fabaceae) is an ornamental tree with flamboyant flowers. Objective: to carry out pharmacognostical studies to evaluate the features of different D. regia organs, quantification and HPLC profiling of phenolics and flavonoids of leaf extract, also to evaluate possible hepatoprotective activities of the leaf hydroalcoholic extract and its fractions. Materials and Methods: Total phenolic content (TPC) as gallic acid equivalent /100 g dried extract (GAE/100 g DE), and total flavonoid content (TFC) as catechin equivalent /100 g (CE/100 g DE) of the leaves were carried out using Folin-Ciocalteu's and aluminum chloride assays, respectively. Hepatoprotective activity was determined against CCl 4 induced hepatotoxicity in rats. Results: TPC and TFC were 5.5 g GAE/100 g DE and 53.3 g CE/100 g DE respectively, with identification of 13 flavonoids, and 17 phenolics. Hesperidin was present as the highest flavonoid content (48622.5 mg/100 g DE), followed by quercetrin (711.5 mg/100 g DE), whilst hydroxytyrosol was the major identified phenolic compound (1111.2 mg/100g DE) followed by catechin (1026.1 mg/100 g DE). The ethyl acetate fraction showed significant protection against the elevation in the levels of serum biochemical parameters, normal hepatocytes with minimum fatty changes, portal vain congestion and mild inflammatory cell infiltration around the portal vain comparable to CCl 4 group (P< 0.001). The potent and significant hepatoprotective activity of the ethyl acetate fraction may be attributed to its high content of antioxidant phenolic compounds. Thus, the present study may be the first to test the hepatoprotective effect of Delonix regia fractions. INTRODUCTIONThe Caesalpinioideae (Fabaceae) represent approximately 11% of all legume taxa with more than 2250 species of mostly tropical and subtropical trees and shrubs.1 Delonix is a genus of Caesalpinioideae that is widely used in folk medicine. Delonix regia (Hook.) Raf. (Poinciana regia Boj. ex Hook, Gul mohar) is an ornamental tree (10-18 m) with fern-like bipinnately compound leaves and attractive red peacock flowers. It is native to Madagascar and widely grown in Egypt (especially in Cairo and Sinai), lining the streets and gardens for its beauty.2 Delonix regia, with an impressive range of medicinal and biological properties, has been used in folk medicine for the treatment of constipation, inflammation, arthritis, hemiplagia, gynecological disorders, and rheumatism. The leaves were reported to have antidiabetic, 4 anti-inflammatory, 5 antimicrobial and antioxidant activities.6 A methanolic extract of aerial parts possesses hepatoprotective activity against CCl 4 -induced hepatotoxicity in rats.7 Chemically, the leaves are reported to contain lupeol, epilupeol, β-sitosterol 8 and phenolic acids (gallic, protocatechuic and salicylic acids).9 It is well established that phenolic antioxidants, including flavonoids and phenolic acids, are commonly distributed in plant leaves. Natural flavonoids and phenolic acids ha...

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Phytochemical, cytotoxic, hepatoprotective and antioxidant properties of Delonix regia leaves extract

Cited by 69 publications

References 24 publications

Phytochemical study, cytotoxic, analgesic, antipyretic and anti-inflammatory activities of Strychnos nux-vomica

Phytochemical study, cytotoxic, analgesic, antipyretic and anti-inflammatory activities of Strychnos nux-vomica

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

Pharmacognostical and Biological Studies of Delonix regia growing in Egypt: HPLC Profiles

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