Phytochemical Constituents from the Rhizomes of<i>Osmunda japonica</i>Thunb and Their Anti-oxidant Activity

Woo, Kyeong Wan; Jung, Ja Kyun; Lee, Hyun Joo; Kim, Tae Muk; Kim, Min Suk; Jung, Ho Kyung; An, Byeong‐Kwan; Ham, Seong Ho; Jeon, Byung Hun; Cho, Hyun Woo

doi:10.20307/nps.2017.23.3.217

Cited by 10 publications

(2 citation statements)

References 13 publications

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“…The structures of 29 known compounds were confirmed as bersimoside I ( 1 ), 22 abrisaponin L ( 2 ), 23 kuzusapogenol A methyl ester ( 3 ), 24 subproside I methyl ester ( 4 ), 25 subproside IV methyl ester ( 5 ), 26 subproside I ( 6 ), 25 sophoraflavone A ( 8 ), 27 vitexin-2″- O -rhamnoside ( 9 ), 17 bayin ( 10 ), 6 lyoniresinol ( 11 ), 28 (+) - isolariciresinol ( 12 ), 29 maltol- O -β- d -glucopyranoside ( 13 ), 30 licoagroside B ( 14 ), 31 5″-methyl-licoagroside B ( 15 ), 31 oxymatrine ( 16 ), 32 dimethyl (2 S ,3 R )-(+)-2-(4-hydroxybenzyl)tartrate ( 18 ), 20 2-(4-hydroxybenzyl) tartrate ( 19 ), 33 4-methyl eucomate ( 20 ), 34 dimethyl eucomate ( 21 ), 34 5-methyluracil ( 22 ), 35 uracil ( 23 ), 35 1,4-dihydroxy-2-methoxybenzene 4- O -β- d -glucopyranoside ( 24 ), 36 4-hydroxybenzoic acid 4-O-β- d -glucopyranoside ( 25 ), 37 gallic acid ( 26 ), 38 4-hydroxybenzoic acid ( 27 ), 39 trimethyl citrate ( 28 ), 40 3-hydroxy-3-methyl- 1,5-dimethyl ester ( 29 ), 41 ethyl-β- d -glucopyranoside ( 30 ), 42 and 1- O -methyl-inositol ( 31 ) 43 ( Figure S1 ) by comparing the measured spectroscopic data with the published values.…”

Section: Resultsmentioning

confidence: 99%

Chemical Constituents from the Roots and Rhizomes of Sophora tonkinensis and Their Effects on Proprotein Convertase Substilisin/Kexin Type 9 Expression

et al. 2022

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This study was conducted to further investigate bioactive molecules from Sophora tonkinensis that can inhibit proprotein convertase substilisin/kexin type 9 (PCSK9) expression. After interpreting NMR spectroscopic data and MS spectral data of all isolates, a new naturally occurring compound, 6-hydroxy-vitexin-2″- O -rhamnoside ( 7 ), was identified along with 30 known compounds. The calculation of the gauge-including atomic orbital (GAIO) and electronic circular dichroism (ECD) proposed the absolute configuration of 17 as (2 S ,3 R )-methyl-2-(4-hydroxybenzyl)tartrate by comparing the calculated ECD with experimental data. All isolates were tested for their inhibitory effects on PCSK9 mRNA expression. Of the tested compounds, (+) - isolariciresinol ( 12 ) inhibited PCSK9 expression via downregulation of HNF1α and SREBPs.

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Section: Resultsmentioning

confidence: 99%

Chemical Constituents from the Roots and Rhizomes of Sophora tonkinensis and Their Effects on Proprotein Convertase Substilisin/Kexin Type 9 Expression

et al. 2022

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“…It has been reported that B. striata contains stilbenes (bibenzyls and phenanthrenes) and polysaccharides [9,10]. There has been evidence that stilbenes from B. striata (BSS) possess anti-inflammatory, antitumor, and antibacterial properties [11,12], indicating that BSS has medical benefits to be promising healthcare products.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Stilbenes from Bletilla striata against Cutibacterium acnes and Its Effect on Cell Membrane

Yu,

Sun,

Peng

et al. 2023

Microorganisms

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The abnormal proliferation of Cutibacterium acnes is the main cause of acne vulgaris. Natural antibacterial plant extracts have gained great interest due to the efficacy and safety of their use in skin care products. Bletilla striata is a common externally used traditional Chinese medicine, and several of its isolated stilbenes were reported to exhibit good antibacterial activity. In this study, the antimicrobial activity of stilbenes from B. striata (BSS) against C. acnes and its potential effect on cell membrane were elucidated by determining the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), bacterial growth curve, adenosine triphosphate (ATP) levels, membrane potential (MP), and the expression of genes related to fatty acid biosynthesis in the cell membrane. In addition, the morphological changes in C. acnes by BSS were observed using transmission electron microscopy (TEM). Experimentally, we verified that BSS possessed significant antibacterial activity against C. acnes, with an MIC and MBC of 15.62 μg/mL and 62.5 μg/mL, respectively. The growth curve indicated that BSS at 2 MIC, MIC, 1/2 MIC, and 1/4 MIC concentrations inhibited the growth of C. acnes. TEM images demonstrated that BSS at an MIC concentration disrupted the morphological structure and cell membrane in C. acnes. Furthermore, the BSS at the 2 MIC, MIC, and 1/2 MIC concentrations caused a decrease in the intracellular ATP levels and the depolarization of the cell membrane as well as BSS at an MIC concentration inhibited the expression of fatty acid biosynthesis-associated genes. In conclusion, BSS could exert good antimicrobial activity by interfering with cell membrane in C. acnes, which have the potential to be developed as a natural antiacne additive.

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Chemical Constituents of the Husk of Xanthoceras sorbifolium

et al. 2023

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Phytochemical Constituents from the Rhizomes ofOsmunda japonicaThunb and Their Anti-oxidant Activity

Cited by 10 publications

References 13 publications

Chemical Constituents from the Roots and Rhizomes of Sophora tonkinensis and Their Effects on Proprotein Convertase Substilisin/Kexin Type 9 Expression

Chemical Constituents from the Roots and Rhizomes of Sophora tonkinensis and Their Effects on Proprotein Convertase Substilisin/Kexin Type 9 Expression

Antimicrobial Activity of Stilbenes from Bletilla striata against Cutibacterium acnes and Its Effect on Cell Membrane

Chemical Constituents of the Husk of Xanthoceras sorbifolium

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