Phytochemical Constituents and Pharmacological Potential of Tamus communis Rhizomes

Abstract

Tamus communis L. is a plant distributed in a number of geographical areas whose rhizome has been used for centuries as an anti-inflammatory and analgesic remedy. This review aims to summarize the current knowledge of the chemical composition and biological activity of the extracts or individual compounds of the rhizome. The data for the principal secondary metabolites are systematized: sterols, steroidal saponins, phenanthrenes, dihydrophenanthrenes, etc. Results of biological tests for anti-inflammatory action, cytotoxicity, anticholinesterase effect, and xanthine oxidase inhibition are presented. Some open questions about the therapeutic properties of the plant are also addressed.

Therapeutic voyage of synthetic and natural xanthine oxidase inhibitors

“…The 4-hydroxybenzoic acid showed a noncompetitive mode of inhibition while apigenin and kaempferol inhibited XO competitively and reversibly (Loh et al, 2022). Slavova et al (2022) isolated compounds from the extracts of Tamus communis rhizomes to evaluate inhibitory activity against XO. Compounds, 5,8-dimethoxypsoralen (IC 50 = 0.099 ± 0.002 mg/mL) and heraclinin (IC 50 = 0.074 ± 0.003 mg/mL) were found to inhibit XO concentration dependently.…”

“…Moreover, some compounds in the extracts displayed a superoxide radical scavenging effect. Subsequently, the relationship between the phenolic content, XO inhibition, and antioxidant activity showed that these activities were based on the phenolic compounds in the testify fractions (Slavova et al, 2022). Liu et al (2022) identified XO inhibitors from pickled radish compounds.…”

“…Slavova et al (2022) isolated compounds from the extracts of Tamus communis rhizomes to evaluate inhibitory activity against XO. Compounds, 5,8‐dimethoxypsoralen (IC 50 = 0.099 ± 0.002 mg/mL) and heraclinin (IC 50 = 0.074 ± 0.003 mg/mL) were found to inhibit XO concentration dependently.…”

Bazi Düzce Halk İlaçlarinin Ki̇motri̇psi̇n, Üreaz İnhi̇be Edi̇ci̇ Ve Anti̇oksi̇dan Akti̇vi̇teleri̇

“…Ancak bitkinin kökleri üzerinde yapılan fitokimyasal çalışmalar fenantren ve 9,10-dihidrofenantren (nudol, konfusarin, krizotoksen, herorensol, orkinol gibi) bakımından zengin olduğunu göstermiştir. Ayrıca β-sitosterol, stigmasterol ve kampesterol gibi steroller taşıdığı da bilinmektedir [31]. Bildiğimiz kadarıyla fenatrenlerin üreaz enzimi üzerindeki etkisi henüz değerlendirilmemiştir ancak daha önceki bir çalışmada sterol yapısındaki ursolik asidin üreaz enzimini %52 oranında inhibe ettiği gösterilmiştir [32].…”