Phytochemical Constituents and Antimicrobial Activity of Elaeocarpus sphaericus Schum Seed Extract

doi:10.26538/tjnpr/v5i10.13

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“…Kompleksitas kandungan senyawa kimia tumbuhan genitri mempunyai potensi untuk dapat digunakan sebagai antioksidan, sehingga mampu memberikan kebermanfaatan dalam pengobatan penyakit (Primiani et al, 2021;Singh et al, 2015;Talukdar et al, 2017). Berdasarkan hasil penelitian kompleksitas senyawa kimia pada tumbuhan genitri, maka perlu dilakukan penelitian secara in vivo, penggunaan biji dan buah genitri dalam menurunkan kadar gula darah serta perubahan struktur jaringan pankreas, tubulus seminiferus testis, dan ginjal.…”

Section: Pendahuluanunclassified

Uji In Vivo Elaeocarpus sphaericus Schum terhadap Kadar Gula Darah dan Struktur Jaringan Testis, Pankreas, dan Ginjal

Primiani¹,

Pujiati²,

Setiawan³

2023

Bioscientist j. ilm. bosbiol.

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Genitri plant (Elaeocarpus sphaericus Schum) has a complex chemical compound that has the potential to lower blood sugar levels. The purpose of this study was to analyze in vivo blood sugar levels and changes in tissue structure of the pancreas, testes seminiferous tubules, and sucrose-induced kidneys. The study used an experimental approach, 24 male Mus musculus mice were grouped into 4 treatment groups. Negative control (P0), positive control giving sucrose at a dose of 1.125 mg/g (P1); Sucrose induction treatment was at a dose of 1.125 mg/g and Gintri seed simplicia was at a dose of 1.300 mg/g (P2). Experimental animals before being induced by sucrose were fasted for 2 hours. Sucrose induction was carried out for 5 days, the experimental animals were given food and drink ad libitum. Checking blood sugar levels every 4 hours through the tail vein. Blood sugar levels of experimental animals P2 and P3 were 126 mg/ each followed by administration of a solution of genitri seeds and fruit for 36 days, every 6 days data was collected on blood sugar levels. On the 37th day, dislocation, surgery and organ harvesting of the testes, pancreas and kidneys were carried out, and preparation of HE staining tissue was made. Data analysis using One Way Anova. The results showed that sucrose induction reduced the diameter of the islets of Langerhans, increased the diameter of the seminiferous tubules of the testes, and reduced the diameter of the glomerulus of the kidney. Giving genitri seeds and fruit lowers blood sugar levels, affects the tissue structure of the pancreas, testes, and glomerulus. The F value of the diameter of the pancreatic islets of Langerhans 16,662; testicular seminiferous tubule diameter 13,433; Glomerular diameter 28,958.

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Section: Pendahuluanunclassified