Phytochemical compounds involved in the anti-inflammatory effect of propolis extract

Borrelli, Francesca; Maffia, Pasquale; Pinto, Luísa; Ianaro, Angela; Russo, Alessandra; Capasso, Francesco; Ialenti, Armando

doi:10.1016/s0367-326x(02)00191-0

Cited by 222 publications

(152 citation statements)

References 21 publications

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“…Because it is very obvious that in immune system B lymphocytes are stimulated by these cytokines, and then they are changed to plasma cells which would be able to produce antibodies. On the other hand propolis have anti-oxidant (Kumazawa et al, 2004;Nagei et al, 2003;Russo et al, 2002) and antiinflammatory (Borrelli et al, 2002;Dimov et al, 1991) effects, and these are related to inhibition o f prostaglandin synthesis (Namgoong et al, 1994;Toma et al, 1981) as an anti-immune substance and resulting better humoral response. One point which should be …”

Section: Resultsmentioning

confidence: 99%

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Humoral Immunity of Broilers is Affected by Oil Extracted Propolis (OEP) in the Diet

Rahmani

Pourreza²

2005

International J. of Poultry Science

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Section: Resultsmentioning

confidence: 99%

“…macrophages activation (Kimoto et al, 1998;Dimov et al, 1991;Borrelli et al, 2002;Park et al, 2004). The objective of the present study was to evaluate the effect of oil extracted propolis on humoral immune response of the broilers which is important in broiler production.…”

Section: Methodsmentioning

confidence: 99%

Humoral Immunity of Broilers is Affected by Oil Extracted Propolis (OEP) in the Diet

Rahmani

Pourreza²

2005

International J. of Poultry Science

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“…In addition, propolis is known to be a health food that presents antibacterial, antioxidative, immunomodulatory, antifungal, antiviral, antiprotozoal, antiinflammatory and antitumor activities (3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Bosio et al (13) Though the antibacterial activity of propolis essential oil from Paraná and Piauí states has been reported, the literature on the antimicrobial activity of this oil from Rio de Janeiro State is scarce (17,21).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and antibacterial activity of Brazilian propolis essential oil

Oliveira¹,

França²,

Kuster³

et al. 2010

J. Venom. Anim. Toxins incl. Trop. Dis

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ABSTRACT:The present study aimed at investigating the chemical composition of essential oil extracted from Brazilian propolis and the susceptibility of Staphylococcus aureus, Staphylococcus epidermides, Streptococcus pyogenes and Escherichia coli to this substance. The essential oil was obtained by steam distillation of propolis and examined by gas chromatography/mass spectrometry (GC/MS). In addition, the agar diffusion method using filter paper disks was employed. Antibacterial activity was measured as equivalent diameters of inhibition zones (in millimeters) after incubation at 37C for 24 hours. From the 26 identified constituents, β-caryophyllene (12.7%), acetophenone (12.3%) and β-farnesene (9.2%) were found to be major components. New components, namely linalool, methyl hydrocinnamate, ethyl hydrocinnamate, α-ylangene, γ-elemene and valencene, are reported for the first time to be present in propolis essential oil. This oil also exhibited antibacterial activity.

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“…13,14) Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have antibacterial, anticancer, anti-inflammatory and immunomodulatory properties; the anti-inflammatory effects have been known for a long time. [15][16][17][18][19] However, its anti-inflammatory effect on hypertrophic adipocytes is not well understood. We have reported that CAPE has suppression effect on 3T3-L1 differentiation to adipocytes and production of adipocytokines during adipogenesis.…”

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confidence: 99%

Caffeic Acid Phenethyl Ester Suppresses the Production of Pro-inflammatory Cytokines in Hypertrophic Adipocytes through Lipopolysaccharide-Stimulated Macrophages

Juman

Yasui

Ikeda

et al. 2012

Biological & Pharmaceutical Bulletin

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Obesity is a condition in which excess body fat accumulates due to lipids producing adipocytes and an increased number of differentiated mature cells. Recently, new findings have shown that macrophages infiltrate into adipose tissues and produce various pro-inflammatory cytokines in obese subjects. The inflammatory changes induced by the cross-talk between adipocytes and macrophages are critical for the pathophysiology of obesity and thus of metabolic syndrome. Caffeic acid phenethyl ester (CAPE) is known to have many functions, including antibacterial, anticancer and anti-inflammatory properties, but there is no evidence of its effect on the inflammatory responses in hypertrophic adipocytes through stimulation by macrophages. We investigated the effect of CAPE on macrophages and hypertrophic adipocytes in this study. CAPE significantly suppressed the levels of lipopolysaccharide (LPS)-induced interleukin (IL)-1-beta, tumor necrosis factor (TNF)-alpha and monocyte chemoattractant protein (MCP)-1 from a macrophage cell line, RAW264.7. Supernatants of stimulated RAW264.7 macrophages drastically increased mRNA levels of pro-inflammatory cytokines such as IL-6, MCP-1 and TNF-alpha in 3T3-L1 hypertrophic adipocytes. CAPE also significantly and dose-dependently reduced the gene expression of these cytokines. Our findings indicate that CAPE has inhibitory effects on the production of pro-inflammatory cytokines from LPS-stimulated RAW264.7 macrophages. In addition, CAPE suppressed gene expressions of cytokines under inflammatory conditions of hypertrophic adipocytes, suggesting that it may have the potential to suppress inflammation by macrophage infiltration into adipose tissue in obese patients.Key words caffeic acid phenethyl ester; hypertrophic adipocyte; macrophage; pro-inflammatory cytokine Obesity is a major risk factor for metabolic syndrome, which includes a number of disorders, such as hypertension, heart diseases and diabetes.1,2) Obesity is a condition in which excess body fat accumulates due to lipids producing hypertrophic adipocytes and an increased number of differentiated mature cells. This process is regulated by genetic and environmental factors, such as nutrient intake.3,4) It is known that adipocytes in obese individuals show cell hypertrophy and chronic inflammation. The inflammatory changes induced by the cross-talk between adipocytes and macrophages are critical for the pathophysiology of obesity and thus of metabolic syndrome. 5,6) Recent studies have demonstrated that obese adipose tissue is characterized by increased infiltration of macrophages, 7,8) which produce various inflammatory proteins. The inflammation process is associated with the activation of macrophages and the release of pro-inflammatory cytokines, such as interleukin (IL)-1-beta, tumor necrosis factor (TNF)-alpha, monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-6. 9,10) MCP-1, known to play a pivotal role in macrophage trafficking and activation, is produced by macrophages and adipocytes. Several reports suggest t...

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Phytochemical compounds involved in the anti-inflammatory effect of propolis extract

Cited by 222 publications

References 21 publications

Humoral Immunity of Broilers is Affected by Oil Extracted Propolis (OEP) in the Diet

Humoral Immunity of Broilers is Affected by Oil Extracted Propolis (OEP) in the Diet

Chemical composition and antibacterial activity of Brazilian propolis essential oil

Caffeic Acid Phenethyl Ester Suppresses the Production of Pro-inflammatory Cytokines in Hypertrophic Adipocytes through Lipopolysaccharide-Stimulated Macrophages

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