Phytochemical compounds from Jurinea macrocephala subsp.elbursensis and their cytotoxicity evaluation

Atabaki, Vahideh; Pourahmad, Jalal; Hosseinabadi, Tahereh

doi:10.1016/j.sajb.2020.11.011

Cited by 9 publications

(16 citation statements)

References 26 publications

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“…These chemical findings were mostly consistent with some recent phytochemical studies on J. macrocephala and J. macrocephala subsp. elburnensis [10,22] . 6‐ O ‐Methoxylated flavonoid pattern of the plant material is withal convenient with the family Asteraceae.…”

Section: Resultsmentioning

confidence: 99%

“…elbursensis ’s phytochemical ingredients and cytotoxicity assessment on human metastatic breast cancer (MDA‐MB231) and human cervical carcinoma (HeLa) cell lines were recently identified. In this study, isolated three compounds, two germacranolide‐type sesquiterpene lactones, and one furofuran‐type lignin, exhibited strong activity against HeLa cell lines [10] . Prompted by the above mentioned considerations on Jurinea species, we aimed to further investigate the possible cytotoxic effects of Jurinea macrocephala as a naturally occurring plant with potential biological activities.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, isolated three compounds, two germacranolide-type sesquiterpene lactones, and one furofuran-type lignin, exhibited strong activity against HeLa cell lines. [10] Prompted by the above mentioned considerations on Jurinea species, we aimed to further investigate the possible cytotoxic effects of Jurinea macrocephala as a naturally occurring plant with potential biological activities.…”

Section: Introductionmentioning

confidence: 99%

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Isolation, Characterization and in Silico Studies of Secondary Metabolites from Jurinea macrocephala DC. with Antiproliferative Activity

Gürbüz

Doğan

Gündüz

et al. 2022

Chemistry & Biodiversity

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In the present work, cytotoxic potential of Jurinea macrocephala DC. (Asteraceae) was evaluated on A549 lung cancer and MCF‐7 breast cancer cell lines. Isolation studies were carried out using various and repetitive chromatographic methods in order to determine the phytochemical profile of the extracts. These studies led to the identification of twelve compounds; four triterpenes (1–4) and eight flavonoids (5–12). Spectroscopic examination (1D and 2D NMR, ESI‐MS) and comparison with relevant literature data were used to deduce the structures of all isolated molecules. To rationalize the obtained cytotoxicity data against breast cancer cell lines, the isolated compounds were docked into the binding site of aromatase, an important target enzyme for the treatment of breast cancer. Molecular docking studies revealed that flavonoids without sugar moieties (5–8) showed the best binding affinities. Overall, these mentioned compounds turned out to be also the most appropriate oral drug candidates after the calculation of their Lipinski parameters.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Isolation, Characterization and in Silico Studies of Secondary Metabolites from Jurinea macrocephala DC. with Antiproliferative Activity

Gürbüz

Doğan

Gündüz

et al. 2022

Chemistry & Biodiversity

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“…Following this work, Atabaki and colleagues performed in silico and in vitro studies to evaluate the behavior of phytochemicals of Jurinea macrocephala subsp. Elbursensis in CC cell lines and their interaction with E6 HPV18 [ 54 ]. From this plant, three compounds were isolated, namely, 4-hydroxypectorolide-14- O -acetate, 4-hydroxy pectorolide, and pinoresinol monomethyl ether- β -D-glucoside (PMG), and their toxicity toward cancer cells was investigated.…”

Section: E6 Proteinmentioning

confidence: 99%

“…Of these, compound 18 , PMG ( Figure 5 ), displayed significant toxicity on HeLa cells; therefore, molecular docking was performed to understand if it could be a potential E6 inhibitor. Using doxorubicin as control, the PMG showed higher binding energy (−4.75 Kcal/mol) and interacted through H-bonds with three amino acid residues (Arg119, Leu112, and Tyr99) [ 54 ].…”

Section: E6 Proteinmentioning

confidence: 99%

In Silico Approaches: A Way to Unveil Novel Therapeutic Drugs for Cervical Cancer Management

et al. 2021

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Cervical cancer (CC) is the fourth most common pathology in women worldwide and presents a high impact in developing countries due to limited financial resources as well as difficulties in monitoring and access to health services. Human papillomavirus (HPV) is the leading cause of CC, and despite the approval of prophylactic vaccines, there is no effective treatment for patients with pre-existing infections or HPV-induced carcinomas. High-risk (HR) HPV E6 and E7 oncoproteins are considered biomarkers in CC progression. Since the E6 structure was resolved, it has been one of the most studied targets to develop novel and specific therapeutics to treat/manage CC. Therefore, several small molecules (plant-derived or synthetic compounds) have been reported as blockers/inhibitors of E6 oncoprotein action, and computational-aided methods have been of high relevance in their discovery and development. In silico approaches have become a powerful tool for reducing the time and cost of the drug development process. Thus, this review will depict small molecules that are already being explored as HR HPV E6 protein blockers and in silico approaches to the design of novel therapeutics for managing CC. Besides, future perspectives in CC therapy will be briefly discussed.

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Evaluation of Fatty Acid Contents and Biological Activities of Jurinea turcica

Bahadır Semerci,

Yıldırım,

Oztay

et al. 2023

Chemistry & Biodiversity

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The fatty acid profile, antioxidant/antibacterial, and cytotoxic effects of the extracts obtained from Jurinea turcica B.Doğan& A.Duran have been evaluated for the first time in the current study. The fatty acid profile of ethanolic extracts was determined using the Soxhlet extractor by a gas chromatography‐mass spectrometer. The antioxidant and antibacterial activities were measured by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging and ferrous reduction tests and the disc diffusion technique. Additionally, the cytotoxicity and wound healing assays were performed on A549 cells. The highest amount of component in the leaf extract was docosanoic acid methyl ester, whereas abundant arachidonic acid methyl ester was mainly found in the flower extract. The IC50 values, the 50 % scavenging value for the DPPH radical, were 179.13 and 124.67 μg/mL for the leaf and flower extracts, respectively. IC50 values (the half‐maximal inhibitory concentration) were 10.4 and 24.7 μg/mL for the flower and leaf extracts, respectively. The leaf extract showed more potent antibacterial activity on Enterococcus faecalis (17 mm) and Staphylococcus aureus (16 mm) bacteria than the flower extract. In conclusion, the extracts of J. turcica have anti‐cancerogenic and antibacterial effects. Leaf extracts have antibacterial and anti‐metastatic effects, while flower extracts show antioxidant, cytotoxic, and apoptotic properties in A549 cells.

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Phytochemical compounds from Jurinea macrocephala subsp.elbursensis and their cytotoxicity evaluation

Cited by 9 publications

References 26 publications

Isolation, Characterization and in Silico Studies of Secondary Metabolites from Jurinea macrocephala DC. with Antiproliferative Activity

Isolation, Characterization and in Silico Studies of Secondary Metabolites from Jurinea macrocephala DC. with Antiproliferative Activity

In Silico Approaches: A Way to Unveil Novel Therapeutic Drugs for Cervical Cancer Management

Evaluation of Fatty Acid Contents and Biological Activities of Jurinea turcica

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