Phytochemical composition, antiparasitic and α–glucosidase inhibition activities from Pelliciera rhizophorae

Lopéz, Dioxelis; Chérigo, Lilia; Spadafora, Carmenza; Loza-Mejía, Marco A.; Martínez-Luis, Sergio

doi:10.1186/s13065-015-0130-3

Cited by 25 publications

(21 citation statements)

References 28 publications

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“…A. rotundifolia is a small tree originating from the Plumbaginaceae family with a height of 2–3 m. It has broad and ovate leaves, 5–8.8 cm long and 4.5–8.5 cm wide [44,45]. The species is mainly grown in Bangladesh and is used to cure inflammatory and painful arthritis [72,73].…”

Section: Resultsmentioning

confidence: 99%

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Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves―A Comprehensive Review

et al. 2019

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Mangroves are ecologically important plants in marine habitats that occupy the coastlines of many countries. In addition to their key ecological importance, various parts of mangroves are widely used in folklore medicine and claimed to effectively manage a panoply of human pathologies. To date, no comprehensive attempt has been made to compile and critically analyze the published literature in light of its ethnopharmacological uses. This review aims to provide a comprehensive account of the morphological characteristics, ethnobotany, global distribution, taxonomy, ethnopharmacology, phytochemical profiles, and pharmacological activities of traditionally used mangroves. Out of 84 mangrove species, only 27 species were found to be traditionally used, however not all of them are pharmacologically validated. The most common pharmacological activities reported were antioxidant, antimicrobial, and antidiabetic properties. Mangroves traditionally reported against ulcers have not been extensively validated for possible pharmacological properties. Terpenoids, tannins, steroids, alkaloids, flavonoids, and saponins were the main classes of phytochemicals isolated from mangroves. Given that mangroves have huge potential for a wide array of medicinal products and drug discovery to prevent and treat many diseases, there is a dire need for careful investigations substantiated with accurate scientific and clinical evidence to ensure safety and efficient use of these plants and validate their pharmacological properties and toxicity.

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Section: Resultsmentioning

confidence: 99%

“…P. rhizophorae , also known as tea mangrove, is endemic to the coastline of Central America [44]. It comes from the Tetrameristaceae family.…”

Section: Resultsmentioning

confidence: 99%

Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves―A Comprehensive Review

et al. 2019

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“…Recent advances in drug discovery in Panama, specifically bioactive components extracted from the bacterium Bacillus pumilus , which was isolated from the black coral Antipathes sp., have shown the ability to constrain the growth of T. cruzi [ 73 ]. Other compounds derived from Panamanian isolates of the mangrove Pelliciera rhizophorae have also demonstrated selective anti-parasitic activity against T. cruzi [ 74 ]. It is worth mentioning that drug trials in Panama using bioactive components extracted from bacteria, corals, and other trypanostatics have all been in vitro.…”

Section: Introductionmentioning

confidence: 99%

“…A recent study demonstrated the utility of the macro-ecological approach to better understand the spatial-temporal transmission dynamic of leishmaniasis in Panama [ 116 ], but similar work on CHD has not yet been conducted. In addition, there is a need for developing new and innovative strategies for vector control and more effective and less toxic drugs to treat infected people [ 72 , 74 ]. More specifically, scientific studies about population genetics and niche dynamics of major epidemiologic components of CHD (i.e.…”

Section: Introductionmentioning

confidence: 99%

American trypanosomiasis, or Chagas disease, in Panama: a chronological synopsis of ecological and epidemiological research

Rodríguez

Loaiza

2017

Parasites Vectors

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American trypanosomiasis, or Chagas disease, is a growing public health problem in Panama, and further forest degradation due to human population growth is expected to worsen the situation. Most people infected with the parasite Trypanosoma cruzi are silently ill, and their life expectancy is severely compromised, which contributes to further deterioration of living conditions in endemic regions. Here, we review the outcomes of nearly 100 years of ecological and epidemiological investigation about Chagas disease in Panama, in an attempt to highlight progress, identify needs, and re-orient future efforts. Rhodnius pallescens and Triatoma dimidiata are both primary vectors of T. cruzi in Panama, but R. pallescens seems more efficient in human-altered forest ecosystems due to a greater degree of association with Attalea butyracea. In contrast, T. dimidiata transmits T. cruzi efficiently under more sylvatic conditions (e.g. settlements inside old-growth or secondary forest patches), where its populations reach considerable numbers irrespective of the absence of A. butyracea. A trend of increasing forest degradation, suburbanization, and development of tourism in Panama favoring the establishment of A. butyracea and other palm tree species (Acrocomia sp.) suggests that a colonist species like R. pallescens will continue to play a more prominent role in the transmission of T. cruzi than a forest specialist like T. dimidiata. However, studies about the taxonomic status and ecology of these vectors are still needed in Panama to address their transmission potential fully. The implementation of an active surveillance system and education programs could greatly minimize the risk of Chagas disease transmission in Panama, preventing fatal infections in children from endemic areas.

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“…α-glucosidase enzyme bioassays were conducted following the protocol of Lopez et al (2015) using acarbose as a positive control.…”

Section: Malaria and α-Glucosidase Bioassaysmentioning

confidence: 99%

Diversity and Allelopathic Potential of Weeds among Panamanian Coffee Crops

Chérigo¹,

Lezcano²,

Martínez-Luis³

2017

OnLine Journal of Biological Sciences

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Worldwide, coffee is one of the most highly consumed and produced crops. Coffee production is a significant activity in the Panamanian economy, mainly in rural communities and among indigenous groups in the Chiriquí province highlands. Weeds growing alongside coffee plants can provoke considerable economic losses for producers by interfering with the growth, development and yield of coffee crop in cultivated areas. Designing an effective program to control weeds depends on identifying the different species found in the coffee plantations. The objective of this study was to assess the biological diversity and negative allelopathic potential of weeds in a coffee field to generate enough information that would better allow farmers to control them. As a result, we identified forty-two different species of weeds in all sampling transects within the study area. Emilia sonchifolia and Impatiens walleriana were the most abundant. In respect to phytotoxic activity, Emilia sonchifolia and Hyptis capitata showed the highest activity against the seed germination of dicotyledonous species Amaranthus hypochondriacus, exhibiting IC 50 values of 160 and 178 µg mL , respectively. Finally, we proceeded to evaluate the organic extracts of two coffee weeds in a panel of bioassays to demonstrate to the farmers that weeds may also have useful applications for human health. Borreria verticillata showed antimalaric activity while Blechum pyramidatum displayed inhibition of the α-glucosidase enzyme. These results allow us to propose a rational and systematic management of coffee weeds.

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Phytochemical composition, antiparasitic and α–glucosidase inhibition activities from Pelliciera rhizophorae

Cited by 25 publications

References 28 publications

Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves―A Comprehensive Review

Ethnopharmacology, Phytochemistry, and Global Distribution of Mangroves―A Comprehensive Review

American trypanosomiasis, or Chagas disease, in Panama: a chronological synopsis of ecological and epidemiological research

Diversity and Allelopathic Potential of Weeds among Panamanian Coffee Crops

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