Phytochemical Composition, Antioxidant Potential and Cholinesterase Inhibition Potential of Extracts from <i>Mentha pulegium</i> L.

Politeo, Olivera; Bektašević, Mejra; Carev, Ivana; Jurin, Mislav; Roje, Marin

doi:10.1002/cbdv.201800374

Cited by 22 publications

(18 citation statements)

References 39 publications

(45 reference statements)

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“…El-Tarf [35] Tunisia [43] Croatia [15] Turkey [ The amount of extracted phenolics depends on some parameters, including the extraction temperature, time, pH, and solvent polarity [57,58]. The results of other authors may vary moderately from ours due to these factors.…”

Section: Plant Current Study Previous Studiesmentioning

confidence: 80%

“…There are many studies focusing on the biological and pharmacological studies of plants (aerial and underground parts) in folk medicine [ 13 , 14 , 15 ]. Several studies on medicinal plants have reported that there are marked differences in chemical composition (total flavonoid, total phenolic contents), mineral count, and biological activity due to differences in geographical regions and locations across the world.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Extraction Methods on Polyphenols, Flavonoids, Mineral Elements, and Biological Activities of Essential Oil and Extracts of Mentha pulegium L.

et al. 2021

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Our study evaluated the in vitro antioxidant properties, antibacterial and antifungal activities, anti-inflammatory properties, and chemical composition of the essential oils (EOs), total phenol, and total flavonoid of wild Mentha pulegium L. This study also determined the mineral (nutritional and toxic) elements in the plant. The EOs were extracted using three techniques—hydro distillation (HD), steam distillation (SD), and microwave-assisted distillation (MAD)—and were analyzed using chromatography coupled with flame ionization (GC-FID) and gas chromatography attached with mass spectrometry detector (GC-MS). The antioxidant effects of the EOs were tested with 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), while the antibacterial and antifungal activities of the EO and methanolic extract were tested using Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. Twenty-six compounds were identified in the essential oil, representing 97.73% of the total oil, with 0.202% yield. The major components were pulegone (74.81%), menthone (13.01%) and piperitone (3.82%). Twenty-one elements, including macro- and micro-elements (Ba, Br, Ca, Cl, Co, Cr, Cs, Eu, Fe, K, Mg, Mn, Mo, Na, Rb, Sb, Sc, Sr, Th, U and Zn), were detected using neutron activation analysis (INAA) and inductively coupled plasma optical emission spectrometry (ICP-OES), with the concentration of mineral element close to the FAO recommendation. The results show that the EOs and extracts from Mentha pulegium L. had significant antimicrobial activities against the microorganisms, including five human pathogenic bacteria, one yeast (Candida albicans), and one phytopathogenic fungi. The in vivo anti-inflammatory activities of the leaf extracts were confirmed. The results indicate that the EOs and extracts from Mentha pulegium L. have promising applications in the pharmaceutical industries, clinical applications, and in medical research.

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Section: Plant Current Study Previous Studiesmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Effect of Extraction Methods on Polyphenols, Flavonoids, Mineral Elements, and Biological Activities of Essential Oil and Extracts of Mentha pulegium L.

et al. 2021

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“…Several authors have documented the antioxidant activity of Mentha pulegium extracts and the essential oils originating from Mentha pulegium . 42 As AgNPs would be coating by the bioactive constituent involved in the Mentha pulegium leaf extract, the AgNPs biosynthesized using Mentha pulegium leaf extract are anticipated to exhibit powerful antioxidant activity. Thus, we performed the DPPH experiment to evaluate the antioxidant activity of biosynthesized AgNPs, where the DPPH method is considered as one of the quickest methods.…”

Section: Resultsmentioning

confidence: 99%

Green Fabrication of Bioactive Silver Nanoparticles Using Mentha pulegium Extract under Alkaline: An Enhanced Anticancer Activity

Wang

Wei

2021

ACS Omega

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Fabrication of silver nanoparticles (AgNPs) using Chinese herbal medicine is popular as the bioactive components included in them would generate potential synergistic effect with the metal nanoparticles. The leaf of Mentha pulegium , whose extract contains a range of phytochemicals and exhibits a wide spectrum of bioactivities, is used as Chinese herbal medicine after drying naturally. Thus, the green synthesis of AgNPs using Mentha pulegium has aroused interests from analysts. However, the biosynthesis of AgNPs under alkaline conditions and the biological activities remain elusive, where alkaline conditions may influence the physicochemical properties and the biological activities of biosynthesized AgNPs. In this study, we were stimulated to fabricate bioactive AgNPs using Mentha pulegium extract under alkaline conditions, accompanied by a systematic evaluation on the effect of biosynthesis parameters on the formation, average size, and polydispersity of AgNPs. Our results showed that alkaline conditions could accelerate the formation of AgNPs with a small average size but at a disadvantage to the polydispersity. Additionally, the as-prepared AgNPs had a hexagonal structure and spherical shape with an average size of 15.7 ± 0.1 nm, existing in the monodispersed form and revealing a high degree of stability. The AgNPs exhibited potent antioxidant and significant inhibitory activity for both bacterial and cancer cell lines. The MIC values of AgNPs for Staphylococcus aureus and Escherichia coli were both 50.0 μg·mL –1 , and the IC 50 values for HCT116, HepG2, and HeLa cells were 9.0, 14.5, and 31.5 μg·mL –1 , respectively. The AgNPs biosynthesized using M. pulegium under alkaline conditions, which had a smaller size and more surface loads, are entirely different with those synthesized under acidic conditions, and the anticancer activity increased significantly. The internalization of AgNPs inside these five cells displayed a variant trend with variable AgNPs concentrations, suggesting the different mechanism of cell death. For two pathogens, HCT116 and HepG2 cancer cell lines, both cell wall and intracellular damage may be responsible for the cell death. However, for Hela cell line the cell death may be rooted in oxidative stress or intracellular penetration. These results confirmed that the AgNPs biosynthesized from M. pulegium extract under alkaline conditions would act as better anticancer agents in biomedicine.

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“…All these chemical constituents contribute to multidirectional pharmacological activities. Some of the remarkable bioactivities reported within this plant family are anti-allergic (Malik et al, 2003; Makino et al, 2003; Kim et al, 2009), anti-inflammatory (Borges et al, 2018), antimicrobial (Khoury et al, 2016; Cocan et al, 2018), free radical scavenging (Khaled-Khodja et al, 2014; Politeo et al, 2018), antinociceptive (Hwang et al, 2018; Uritu et al, 2018), anti-cancer activities (Nguyen et al, 2018; Sajjadi et al, 2018), etc. Many pharmacological activities of the Lamiaceae family have been widely studied and investigated.…”

Section: Anti-allergic Activitymentioning

confidence: 99%

Lamiaceae: An Insight on Their Anti-Allergic Potential and Its Mechanisms of Action

2019

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The prevalence of allergic diseases such as asthma, allergic rhinitis, food allergy and atopic dermatitis has increased dramatically in recent decades. Conventional therapies for allergy can induce undesirable effects and hence patients tend to seek alternative therapies like natural compounds. Considering the fact above, there is an urgency to discover potential medicinal plants as future candidates in the development of novel anti-allergic therapeutic agents. The Lamiaceae family, or mint family, is a diverse plant family which encompasses more than 7,000 species and with a cosmopolitan distribution. A number of species from this family has been widely employed as ethnomedicine against allergic inflammatory skin diseases and allergic asthma in traditional practices. Phytochemical analysis of the Lamiaceae family has reported the presence of flavonoids, flavones, flavanones, flavonoid glycosides, monoterpenes, diterpenes, triterpenoids, essential oil and fatty acids. Numerous investigations have highlighted the anti-allergic activities of Lamiaceae species with their active principles and crude extracts. Henceforth, this review has the ultimate aim of compiling the up-to-date (2018) findings of published scientific information about the anti-allergic activities of Lamiaceae species. In addition, the botanical features, medicinal uses, chemical constituents and toxicological studies of Lamiaceae species were also documented. The method employed for data collection in this review was mainly the exploration of the PubMed, Ovid and Scopus databases. Additional research studies were obtained from the reference lists of retrieved articles. This comprehensive summarization serves as a useful resource for a better understanding of Lamiaceae species. The anti-allergic mechanisms related to Lamiaceae species are also reviewed extensively which aids in future exploration of the anti-allergic potential of Lamiaceae species.

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Phytochemical Composition, Antioxidant Potential and Cholinesterase Inhibition Potential of Extracts from Mentha pulegium L.

Cited by 22 publications

References 39 publications

Effect of Extraction Methods on Polyphenols, Flavonoids, Mineral Elements, and Biological Activities of Essential Oil and Extracts of Mentha pulegium L.

Effect of Extraction Methods on Polyphenols, Flavonoids, Mineral Elements, and Biological Activities of Essential Oil and Extracts of Mentha pulegium L.

Green Fabrication of Bioactive Silver Nanoparticles Using Mentha pulegium Extract under Alkaline: An Enhanced Anticancer Activity

Lamiaceae: An Insight on Their Anti-Allergic Potential and Its Mechanisms of Action

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