Phytochemical composition and in vitro pharmacological investigations of Neurada procumbens L. (Neuradaceae): A multidirectional approach for industrial products

Phytochemical composition and biological activity of Neurada procumbens L. growing in southern Algeria

“…UHPLC/MS profiling of the methanol extract of the aerial parts of N. procumbens L. (Neuradaceae) (Figure 1) resulted in the tentative identification of 14 compounds including fatty acids, flavones, flavonoids, and sesquiterpenes. Flavones and flavonoids represented by 3,8‐i‐ C ‐β‐D‐glucopyranosyl‐3′,4′,5,7‐tetrahydroxyflavone (Shie et al., 2010), Kaempferol‐3‐(6″‐acetylglucoside)‐7‐glucoside (Khurshid et al., 2019), and orientin 2″‐O‐α‐rhamnopyranoside (Marzouk et al., 2014), are among its main compounds constituting about 9.27%, 4.63%, and 1.23% of the total identified compounds, respectively. Meanwhile fatty acids represented by 2‐butyl‐3‐methylbutanedioic (Shao, Wang, & Li, 2012), 9,10‐epoxyoctadecanedioic (Pinto et al., 2009), 5,8,12‐trihydroxy‐9‐octadecenoic (Xu et al., 2011), 17‐methyl‐6‐octadecenoic (Carballeira, Montano, Balaña‐Fouce, & Prada, 2009), 4,6‐dimethyl‐2,4‐hexadecadienoic (Řezanka & Dembitsky, 2002), and 7,8‐dimethyl‐7‐hexadecenoic (Ratnayake, Olsson, & Ackman, 1989), acids predominate in the extract in addition to the presence of sesquiterpenes represented by emmotin A (Khurshid et al., 2019).…”

“…The cytotoxic activity of the plant extract was tested against both HCT116 (colon cancer) and HePG2 (human hepatocellular carcinoma) using the mitochondrial dependent reduction of yellow MTT ( 1.23% of the total identified compounds, respectively. Meanwhile fatty acids represented by 2-butyl-3-methylbutanedioic (Shao, Wang, & Li, 2012), 9,10-epoxyoctadecanedioic (Pinto et al, 2009), 5,8,12-trihydroxy-9-octadecenoic (Xu et al, 2011), 17-methyl-6-octadecenoic (Carballeira, Montano, Balaña-Fouce, & Prada, 2009), 4,6-dimethyl-2,4-hexadecadienoic (Řezanka & Dembitsky, 2002), and 7,8-dimethyl-7-hexadecenoic (Ratnayake, Olsson, & Ackman, 1989), acids predominate in the extract in addition to the presence of sesquiterpenes represented by emmotin A (Khurshid et al, 2019). Compounds identified from N. procumbens aerial parts and their percentages are illustrated in Table 1.…”

“…Neurada constitutes mainly desert plants which are widely spread in the Arabian Peninsula. Traditionally, they are considered by the Bedouin as edible medicinal herbs (Khurshid et al., 2019).…”

“…The plant has also been used in traditional Arabic medicine to treat diarrhea and dysentery. It has also been used as a stimulant to increase cardiac and breathing functions (Khurshid et al., 2019). Its water extract increased the blood pressure in mice.…”

“…profiling of the methanol extract of the aerial parts of N. procumbens L. (Neuradaceae) (Figure 1) resulted in the tentative identification of 14 compounds including fatty acids, flavones, flavonoids, and sesquiterpenes. Flavones and flavonoids represented by 3,8-i-Cβ-D-glucopyranosyl-3′,4′,5,7-tetrahydroxyflavone (Shie et al, 2010),Kaempferol-3-(6″-acetylglucoside)-7-glucoside(Khurshid et al, 2019), and orientin 2″-O-α-rhamnopyranoside(Marzouk et al, 2014), are among its main compounds constituting about 9.27%, 4.63%, and…”