Phytochemical composition and biological activities of the plants of the genus Randia

Abstract

Background: The genus Randia L. (Rubiaceae) is native to Americas and highly distributed in tropical areas. Some Randia species are used in traditional medicine in some countries to treat diverse illnesses/symptoms of kidney, circulatory system, lungs, diabetes, cancer, inflammation, and against the bites/stings of snakes and other poisonous animals.
 Questions: What are the phytochemical compounds previously identified in Randia? What biological activities do they present?
 Data description: Twenty-eight studies on chemical composition and biological activities of Randia were reviewed. Species names were corroborated in Plants of the World Online and World Flora Online.
 The site and studied years: Studies of Randia of Americas from 1991 to 2021.
 Methods: Database reviewed were PubMed, Scopus, Scielo, BVS, DAOJ, Science Direct, Springer Link, Web of Science, and Google Scholar, employing the keywords Randia and its synonym Basanacantha.
 Results: Six species are the most studied (R. aculeata, R. echinocarpa, R. ferox, R. hebecarpa, R. matudae, and R. monantha). Ethnopharmacology information of 12 species was recovered. One hundred compounds in Randia have been identified (phenolic acids, terpenes, sterols, and others), and diverse biological activities reported in 24 studies (e.g., antimutagenic, antioxidant, and antivenom) have demonstrated for nine species.
 Conclusions: Biological activities found in some species of Randia support their traditional uses, but only the antivenom effect of Randia aculeata has been demonstrated. Randia species could be a source of bioactive compounds; however, knowledge must be expanded to demonstrate their traditional uses and contribute to the development of strategies for their preservation and rational use.
 
 
 Translate
 stop
 
 
 
 
 
 Translate
 stop
 
 

Sacred Trees in Hindu Temples of Theni District, Tamil Nadu: A Perspective of Ethnomedicinal uses and Conservation Study

“…Literature published in the local language (Tamil) and scientific reports have been basis to compare the results and discuss the data. Taxonomic identification was carried out using the flora and leaves [10][11][12][13][14].…”

El fruto del crucetillo (Randia aculeata): alternativa potencial para el control de la garrapata del bovino

“…Además del brevaje, el fruto en sí también se ha reportado como analgésico, antiinflamatorio, y en menor frecuencia se emplea para padecimientos crónicos, como cáncer y diabetes (Ojeda-Ayala et al 2022). El macerado alcohólico de crucetillo también es utilizado como descongestionador, y también como antihemorrágico y antidiarreico, según las experiencias de los consumidores locales.…”

Biological Importance of Phytoconstitents Isolated from the Genus Randia & GC-MS Analysis of Petroleum-Ether Fruit Extract of Randia dumetorum

“…aculeata, Randia hebecarpa, Randia ferox, Randia momantha are the most studied species 4 . Excessive ethnobotanical and ethnomedicinal study of root, bark, leaves, fruit and seeds of this genus are reported in literature.…”

“…It is deciduous shrub with thorns or small tree (height up to 5m. ), which is distributed up to 4000 ft altitude throughout the india 4 . Leaves are oval, wrinkled, shiny & pubescent.…”

“…Genus Randia exhibits a wide array of biological activities like anticancer, antioxidant, anti mutagenic, anti pyretic, anti venom, antiinflammatory, hepatoprotective, abortifacient, haemolytic, molluscicidal, anthelmintic activities 4,[8][9][10][11][12][13][14][15][16] . The phytoconstituents associated with this genus are flavonoids, lignans, sterols, coumarins, tannis, triterpenoids, saponins mainly.…”