Phytochemical composition, and analgesic and antiinflammatory properties of essential oil of <i>Chamaemelum nobile</i> (Asteraceae L All) in rodents

Abstract

Purpose: To investigate the in vivo analgesic and anti-inflammatory activities of essential oil of dried flowers of Chamaemelum nobile (Asteraceae L. All) in Swiss mice and Wistar rats, respectively. Methods: The volatile oil of the dried flowers of C. nobile obtained by hydrodistillation was analyzed by gas chromatography-mass spectrometry (GC-MS). Animals were assigned to the following experimental groups: C. nobile (180 mg/kg), ibuprofen (100 mg/kg) and vehicle-treated groups. Chemical and thermal pain models were used for the antinociceptive study in mice while fresh egg albumin-induced acute inflammation model in rats was used for anti-inflammatory study of the essential oil. Results: The most abundant components of the oil were α-bisabolol (50 %) and farnesene (5.35 %). Oral administration of essential oil (180 mg/kg, po) significantly (p < 0.05) reduced pain and prevented inflammation in the different test models used in this study. Conclusion: The essential oil of the dried flowers of C. nobile shows in vivo analgesic and antiinflammatory activities in rodents, and therefore, possesses potentials for development into effective analgesic and anti-inflammatory agent.

Phytochemistry and Biological Activities of Essential Oils from Six Aromatic Medicinal Plants with Cosmetic Properties

“…Roozbeh and Dong-Jin (2017) [ 36 ] reported that EO from the same plant collected in Iran is characterized by Chamazulene (31.12%), β-Pinene (10.11%), ά-bisabolol (7.32%), a pigenin-7-glucoside (6.20%), ά-bisabololoxide A (5.98%), α-pinene (5.97%), and β–thujone (4.84%). Aremu et al (2018) [ 37 ] also showed a difference in the chemical composition of Chamaemelum nobile EO compared to our study, with alpha-bisabolol being the most abundant quantitatively (>50%). The second most abundant compound was farnesene (5.35%), followed by spathulenol (2.56%).…”

In-vivo anti-inflammatory effects of Roman Chamomile (Chamaemelum nobile) aqueous extracts collected from the National Park of El-Kala (North-East, Algeria)

“…Since ROS plays an important role in the pathogenesis of certain inflammatory diseases, natural antioxidants can scavenge ROS and improve the inflammatory state and consequently combat these disorders (31,32). Several studies have been carried out to prove the antiinflammatory effect of Chamaemelum nobile, including Olukayode et al (33) with an in vivo evaluation of the analgesic and anti-inflammatory effect of Roman chamomile essential oil (compared to ibuprofen). The latter had been used against inflammation found in the mouse paw.…”

Traditional plants from Asteraceae family as potential candidates for functional food industry

“…112 Recently, the oral administration of EO from Roman chamomile reduced paw inflammation and exerted analgesic effects against thermal pain, corroborating the use of C. nobile in the treatment of inflammatory disorders. 113 Ps and EOs of Roman chamomile have been also reported to possess in vivo antiinflammatory effects. 110 C. nobile has been described to present cytotoxic effects against several cancer cell lines.…”