Phytochemical characterization of bioactive compounds extracted with different solvents from Calophyllum inophyllum flowers and activity against pathogenic bacteria

Vittaya, Luksamee; Chalad, Chakhriya; Ratsameepakai, Waraporn; Leesakul, Nararak

doi:10.1016/j.sajb.2023.01.052

Cited by 8 publications

(16 citation statements)

References 35 publications

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“…Aqueous and methanolic extracts of A. martini rhizome, referred to as AM01 and AM0, respectively, contained main phytochemical components of phenolics, flavonoids, terpenoids, and alkaloids [23,24] . Phenolic compounds had hydroxyl groups that showed free radical scavenging activity [27,28] .…”

Section: Resultsmentioning

confidence: 99%

“…These phytochemicals showed higher levels of antioxidant activity than synthetic antioxidants (butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), or ascorbic acid. For example, rhizome extracts of A. martini inhibited free radicals better than BHT and ascorbic acid, [23] and inhibited a wide range of Gram‐positive and Gram‐negative pathogenic bacteria [24,26] . We believe that A. martini extracts are a safe and eco‐friendly material to use in the synthesis of ZnO NPs.…”

Section: Introductionmentioning

confidence: 89%

“…In addition, A. martini root is used as a late‐night remedy for constipation, bruising, and coughing. Phenolics, terpenoids, and saponins have been found in the vine, rhizomes, and leaves of A. martini [23–25] . These phytochemicals showed higher levels of antioxidant activity than synthetic antioxidants (butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), or ascorbic acid.…”

Section: Introductionmentioning

confidence: 99%

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Green Synthesis and Biological Activities of Zinc Oxide Nanoparticles using Ampelocissus martini Rhizome Extract

Vittaya,

Chalad,

Sirimahachai

2024

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Zinc oxide nanoparticles (ZnO NPs) were prepared by co‐precipitation of zinc acetate with Ampelocissus martini rhizome extract (AM). Four conformations of ZnO NPs were obtained by conjoined precipitation of sodium hydroxide, zinc acetate dihydrate, and AM: ZnO NPs‐01, ZnO NPs‐02, ZnO NPs‐03, and ZnO NPs‐04. The structure of ZnO NPs was confirmed by X‐Ray diffraction (XRD). Fourier transform infrared (FTIR) analysis was conducted to identify functional groups. The formation and morphology of the synthesized ZnO NPs were confirmed by field emission scanning electron microscopy (FE‐SEM) with Energy dispersive X‐ray spectroscopy (EDS) mapping, and transmission electron microscopy (TEM). Free radical scavenging activity was determined by 2,2‐diphenyl‐1‐picryl‐hydazyl‐hydrate (DPPH) and 2,2/‐azino‐bis‐(3‐ethylbenzothi‐azoline‐6‐sulfonic acid (ABTS) assays. Antibacterial activity was examined by disc diffusion analysis together with minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). ZnO NPs‐04 showed the highest inhibition in DPPH and ABTS assays and was active against E. coli and S. aureus with MICs=10 mg/mL and 5 mg/mL, respectively. These findings indicated that synthesized NPs could be utilized for several medicinal applications.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Green Synthesis and Biological Activities of Zinc Oxide Nanoparticles using Ampelocissus martini Rhizome Extract

Vittaya,

Chalad,

Sirimahachai

2024

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“…Phytochemical investigations of Derris from a variety of geographic regions of southern Thailand in our study are the first report on the HPLC fingerprint profile of the unknown Derris species and D. pubipetala. Previously, some articles mentioned the uses of HPLC fingerprint in legumes for Pharmaceutical (drug quality control) or chemotaxonomic purposes (Xie et al 2014;Yang et al 2014;da Costa et al 2016;Orak et al 2016;Stefanucci et al 2022), also in the genus Derris (Vittaya et al 2014;Chen et al 2015;Zabairi et al 2015;Saraf and Shinede 2016;Saraf and Shinede 2018). The results showed peaks of unique chemical markers with reasonable heights and acceptable resolution, that can be used for the rapid identification of the unknown Derris species and D. pubipetala.…”

Section: Discussionmentioning

confidence: 99%

Morphological, anatomical, phytochemical, and phylogenetic evidences reveal into a new Derris species (Fabaceae) with rare flowers and reddish midribs, from Peninsular Thailand

Boonprajan¹,

Leeratiwong²,

Sirichamorn³

2023

Preprint

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Derris erythrocosta Boonprajan & Sirich., sp. nov., a new species of the genus Derris Lour. (Fabaceae) was discovered from Peninsular, Thailand. The taxon was considered as a distinct species in terms of integrative taxonomy approach. The overall morphology demonstrated that this species most resembled D. pubipetala. According to the macro-morphological and leaves micro-morphological studies, this taxon has several autapomorphies distinctively different from other Derris species, e.g., the presence of reddish midribs of the mature leaflets, sparsely hairy filaments, prominent hairs at base of anthers, and presence of glandular trichomes along the midrib. Additionally, HPLC fingerprints from phytochemical study of this species were also distinct.  Results from molecular phylogenetic analyses strongly supported and clearly confirmed its status as a new of the genus Derris.

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“…It distributes across Thailand, especially in the coastal regions. With its medium-sized stature, reaching heights of 20–30 meters, it thrives in diverse landscapes, including forests, mangroves, coastal areas, and tropical regions [ 8 , 9 ]. This plant has been recognized as one of the most important medicinal plants in Ayurvedic and Thai traditional medicine with various parts including leaves, flowers, and stem barks with medicinal properties [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profiles and Anticancer Effects of Calophyllum inophyllum L. Extract Relating to Reactive Oxygen Species Modulation on Patient-Derived Cells from Breast and Lung Cancers

et al. 2023

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Reactive oxygen species (ROS) contribute to cancer growth and metastasis. Using antioxidants to modulate cellular ROS levels is a promisingstrategy for cancer prevention and treatment. Calophyllum inophyllum L., or tamanu, is a medicinal plant renowned for its anti-inflammatory, antioxidant, and anticancer properties in traditional medicine systems. However, the anticancer effects of C. inophyllum extract on cellular ROS remain unexplored. This study represents the first report on such effects and provides the potential mechanisms underlying the anticancer properties of C. inophyllum extract. The branches of C. inophyllum were extracted, and the extract was comprehensively analyzed for phytochemical constituents, antioxidant capacity, total phenolic content, and total flavonoid content. Subsequently, the extract’s potential anticancer properties were evaluated using patient-derived cells from breast and lung cancer. The results revealed that the C. inophyllum extract possesses notable antioxidant activity and demonstrated no cytotoxicity within the initial 24 h of treatment. However, after 72 h, it exhibited significant antiproliferative effects. Moreover, the extract exhibited inhibitory properties against migration and invasion at concentrations below the IC50, which corresponded to the expression of related genes. Notably, these effects correlated with the reduction of intracellular ROS levels. Overall, our findings highlight the anticancer potential of C. inophyllum extract, emphasize its ability to modulate cellular ROS levels and target key molecular pathways involved in cancer progression. This study sheds light on the promising therapeutic implications of C. inophyllum extract as a novel agent for cancer treatment, which is safe for normal cells.

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Phytochemical characterization of bioactive compounds extracted with different solvents from Calophyllum inophyllum flowers and activity against pathogenic bacteria

Cited by 8 publications

References 35 publications

Green Synthesis and Biological Activities of Zinc Oxide Nanoparticles using Ampelocissus martini Rhizome Extract

Green Synthesis and Biological Activities of Zinc Oxide Nanoparticles using Ampelocissus martini Rhizome Extract

Morphological, anatomical, phytochemical, and phylogenetic evidences reveal into a new Derris species (Fabaceae) with rare flowers and reddish midribs, from Peninsular Thailand

Phytochemical Profiles and Anticancer Effects of Calophyllum inophyllum L. Extract Relating to Reactive Oxygen Species Modulation on Patient-Derived Cells from Breast and Lung Cancers

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