Phytochemical Characteristics of Astragalus vulpinus Willd. Herb and Psychomodulating Activity of its Extract

An experimental study is devoted to the investigation of the effect of extract Astragalus physodes on the behavioral reactions of laboratory animals in conditions of «social» stress. Material and methods. The work was carried out toward white outbred male rats of 6-8 months of age. All animals were divided into groups (n = 10): 1 -intact rats, which were singly in the cell (control group); 2 -animals exposed to «social» stress (victims/aggressors); 3 -individuals exposed to «social» stress and received extract Astragalus physodes by intragastric gavage at a dose of 50 mg/kg/day for 14 days, starting from the 21 days of the experiment (victims/aggressors). «Social» stress was modeled by the formation of aggressive (aggressors) and submissive (victim) types of behavior in conditions of paired sensory contact. In studying the behavioral reactions of rats, psychopharmacological tests were used in the standard modification: «Elevated plus maze» and «Tail hanging». Results and discussion. In conditions of «social» stress, in the tests «Elevated plus maze» and «Tail hanging» among aggressors and victims, there is an increase in the level of anxiety and depression, which is manifested in a decrease in the number of rearing, the time spent on the open arms of the labyrinth. The results of the study indicate the ability of the herb extract Astragalus physodes under conditions of «social» stress to level the state of anxiety, which is manifested in an increase in the motor and approximate research activity of laboratory animals. Conclusions. Thus, the herb extract Astragalus physodes eliminates the increased anxiety generated under the influence of stressogenic effects, thereby exhibiting psychomodulatory properties, which actualizes further in-depth pharmacological studies of this extract with the aim of possibly creating medicinal preparations based on it.

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Phytochemical Analysis of <i>Elaeagnus argentea</i> Leaves

Salnikova

Шур

Цибизова

2021

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. Currently, close attention in the field of pharmacy and medicine is directed to the search for new sources of biologically active substances of various origins, including vegetable. The woody plant Elaeagnus argentea is considered as a promising source. Despite its widespread use in the food industry, folk medicine as an anti-inflammatory, restorative, antimicrobial agent, the chemical composition of this plant has not been sufficiently studied.Aim. Qualitative and quantitative determination of the main groups of biologically active substances (BAS) in the raw material (leaves) of Elaeagnus argentea growing on the territory of the Astrakhan region for further development of a methodology for standardizing the raw material of this plant.Materials and methods. The leaves of Elaeagnus argentea were harvested in the spring in the eastern part of the delta of the Astrakhan region (Volga region). Drying of raw materials was carried out in natural conditions. In the study, unified methods were used: to determine the amount of flavonoids and saponins, the spectrophotometric method was used, ascorbic acid - the titrimetric method. For the analysis of flavonoids in the leaves of Elaeagnus argentea, an aqueous-alcoholic solution of 70 % concentration was used as an extractant. The quantitative content of flavonoids was determined in the obtained raw material extract in terms of luteolin-7-glucoside. The amount of saponins in the leaves of Elaeagnus argentea was determined in terms of oleanolic acid. 96 % ethanol was used as an extractant. The quantitative determination of ascorbic acid in the aqueous extract of crushed raw materials was carried out by titrimetry based on the ability to reduce 2,6-dichlorophenolindophenol.Results and discussion. In the pharmacognostic study of biologically active substances in the leaves of Elaeagnus argentea, the content of ascorbic acid was found to be at least 0.32 %, the amount of flavonoids in terms of luteolin-7-glucoside was at least 1.92 %; saponins - 2.38 %; which indicates the need for a more detailed study of the phytochemical composition of other morphological groups of the plant Elaeagnus argentea growing in the Astrakhan region.Conclusion. The data obtained during the study can be used to confirm the quality of raw materials (leaves) of Elaeagnus argentea. A more detailed study of leaves for the presence of other groups of biologically active substances will make it possible to use the obtained data for the development of regulatory documents for medicinal plant raw materials «Elaeagnus argentea leaves».

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Phytochemical Characteristics of Astragalus vulpinus Willd. Herb and Psychomodulating Activity of its Extract

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Utilizing preclinical models of genetic diversity to improve translation of phytochemical activities from rodents to humans and inform personalized nutrition

Utilizing preclinical models of genetic diversity to improve translation of phytochemical activities from rodents to humans and inform personalized nutrition

Effect of Astragalus physodes extract on animal behavioral responses under «social» stress

Phytochemical Analysis of <i>Elaeagnus argentea</i> Leaves

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