A significant amount of research attention has been devoted to the integration of metal-organic frameworks (MOFs) into 2D structures and their derivatives due to their remarkable properties, including high specific surface areas, adjustable pore sizes, and ease of functionalization. Consequently, they offer unique advantages in various fields such as catalysis, energy storage, optoelectronics, switches, and switchable devices. Some of the recent advances in this field are presented in this special issue and are briefly described below.