Phytochemical, Antioxidant, Toxicological, and Pharmaceutical Evaluation of Polyherbal Formulation: Irochel

Ghayas, Syma; Hannan, Abdul; Rizwani, Ghazala H.

doi:10.1177/15593258211073412

Cited by 2 publications

(1 citation statement)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These formulations have been traditionally used in various cultures for the management of liver diseases, and recent studies have shown promising results in their hepatoprotective effects, with negligible side effects (Iroanya, Adebesin & Okpuzor 2014;Padmanabhan & Jangle 2014;Shetty et al 2018Shetty et al , 2020. They have been found to contain a variety of bioactive compounds such as flavonoids, alkaloids and terpenoids, which exhibit various pharmacological activities such as antioxidant, antiinflammatory and hepatoprotective effects (Ghayas, Hannan & Rizwani 2022).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective activities of polyherbal formulations: A systematic review

Aladejana,

Aladejana

2023

Journal of Medicinal Plants for Economic Development

View full text Add to dashboard Cite

Background: Liver diseases pose a substantial global public health challenge, encompassing conditions such as liver failure, hepatitis, cirrhosis and associated complications Safeguarding the liver becomes important as these conditions impact human health. Hepatoprotective agents play a pivotal role in mitigating liver damage caused by chemicals, drugs and toxins. Polyherbal formulations, combining botanical components from traditional medicine, offer a promising approach to addressing liver disorders. Their popularity arises from a multi-targeted strategy in treating complex diseases, marking a shift in focus toward these formulations.Aim: The study aimed to conduct a thorough review of the existing literature on the hepatoprotective activity of polyherbal formulations and provide a comprehensive overview of their mechanisms of action. This review provides the overview of the use of polyherbal formulations in the management of liver disease.Method: A systematic search of electronic databases, including : Scopus, Academia, Elsevier, Science Direct, Wiley, BioMed Central, PubMed, and Google Scholar, was conducted using a combination of keywords such as ‘polyherbal formulations’, ‘hepatoprotective’ and ‘liver diseases’. Studies published between January 2010 and April 2023 were included in the review.Results: A total of 61 articles were reviewed, and the studies showed that polyherbal formulations possess significant hepatoprotective activity against various hepatotoxic agents. The mechanisms of action of these formulations include antioxidant, antiinflammatory, antifibrotic and antiapoptotic effects. Additionally, some polyherbal formulations were found to stimulate liver regeneration, enhance bile secretion and promote detoxification processes.Conclusion: Polyherbal formulations have shown promising hepatoprotective activity, and their multitargeted approach to treating complex diseases makes them a potential alternative to conventional medicines. However, identifying the active compounds responsible for the hepatoprotective effects of these formulations and their pharmacokinetics and pharmacodynamics could provide insights into the development of new and effective drugs for liver disorders.Contribution: This article contributes to the growing body of literature on the potential of polyherbal formulations as hepatoprotective agents.

show abstract

Section: Introductionmentioning

confidence: 99%

Hepatoprotective activities of polyherbal formulations: A systematic review

Aladejana,

Aladejana

2023

Journal of Medicinal Plants for Economic Development

View full text Add to dashboard Cite

show abstract

Chronic (52-week) oral toxicity study of herbal tea of Moringa stenopetala and Mentha spicata leaves formulation in Wistar albino rats

Hassen¹,

Gebru²,

Debella³

et al. 2022

Int J Pharm Sci Dev Res

View full text Add to dashboard Cite

Background: Moringa stenopetala leaves have long been used to treat diabetes, hypertension, respiratory problems, and other diseases. The herbal formulation of Moringa stenopetala and Mentha spicata leaves was found to be more effective in lowering high blood pressure and blood sugar levels. Unlike its pharmacological properties, the long-term safety profile of this herbal formulation has not been investigated yet. Thus, this study investigated the long-term (chronic) oral toxicity of herbal tea of M. stenopetala and M. spicata leaves blended in rats. Methods: Wistar albino rats were randomly distributed into four groups (n = 10/sex/group), and then randomly assigned to a control group and three test groups. The control group (G I) received distilled water. The test groups (G II-IV) received 559.36, 1118.72, and 2237.44 mg/kg of herbal tea of M. stenopetala and M. spicata leaves blend respectively, for 360 consecutive days. During the treatment period, in-life parameters (mortality, clinical symptoms, body weight, and food intake) were evaluated. On the 361st day, hematological, serum biochemical, gross morphological, and histological parameters were investigated. Results: Throughout the 360-day treatment period, no herbal tea-related deaths, severe clinical symptoms, loss of body weight, or food intake were seen in any of the treated groups. Bodyweight, food consumption, organ weight, hematological, and serum biochemical findings showed no significant differences between the control and treated groups in both sexes. Macro-pathological and histopathological examinations of the major organs (liver, kidney, heart, pancreas, stomach, and spleen) revealed no herbal tea-related pathologic alterations. Conclusion: The findings indicate that long-term (360-days) oral administration of the herbal tea of M. stenopetala and M. spicata leaves blend is well tolerated by rats. Hence, it would be safe/low toxic up to a dose of 2237.44 mg/kg/day in chronic exposure.

show abstract

Phytochemical, Antioxidant, Toxicological, and Pharmaceutical Evaluation of Polyherbal Formulation: Irochel

Cited by 2 publications

References 88 publications

Hepatoprotective activities of polyherbal formulations: A systematic review

Hepatoprotective activities of polyherbal formulations: A systematic review

Chronic (52-week) oral toxicity study of herbal tea of Moringa stenopetala and Mentha spicata leaves formulation in Wistar albino rats

Contact Info

Product

Resources

About