Phytochemical, Antibacterial, Antiproliferative, and Antioxidant Potentials and DNA Damage-Protecting Activity ofAcacia salicinaExtracts

Abstract

The extract enriched in total oligomer flavonoids (TOF), and the aqueous, methanol, and ethyl acetate extracts of Acacia salicina were investigated for their polyphenolic compound content, antioxidative activity in the nitro blue tetrazolium/riboflavin assay system, antibacterial activity against Gram-positive and Gram-negative bacterial reference strains, antigenotoxic activity tested with the Ames assay, and cytotoxic activity against the K562 human chronic myelogenous leukemia cell line and L1210 leukemia murine cells. TOF extract was effective at inhibiting nitro blue tetrazolium reduction by superoxide radical in a nonenzymatic O(2)(*-)-generating system. Significant activity against bacterial reference strains Staphylococcus aureus, Enterococcus faecalis, Salmonella enteritidis, and Salmonella typhimurium was shown with all the tested extracts. These extracts significantly decreased the genotoxicity induced by sodium azide and 4-nitro-o-phenylenediamine. A pronounced cytotoxic effect on both leukemia cell lines was detected in TOF, methanolic and ethyl acetate extracts. The antioxidant, antimicrobial, antigenotoxic, and cytotoxic activities exhibited by A. salicina depended on the chemical composition of the tested extracts.

Unexploited Acacia cyanophylla seeds: potential food sources of ω6 fatty acids and antioxidants?

“…Little information is available on antioxidants from Acacia seeds. For Acacia salicina the phenolic content of leaves was ca 0.18 g GAE kg −1 DW 24. The values obtained for A. cyanophylla were lower than those reported by Elfalleh et al 22 for pomegranate seeds (11.84 g RE kg −1 DW) and by Velioglu et al 25 for sunflower seeds (16.01 g kg −1 DW), buckwheat seeds (7.26 g kg −1 DW) and wheat germ (3.49 g kg −1 DW).…”

An in vitro study reveals nutraceutical properties of Ananas comosus (L.) Merr. var. Mauritius fruit residue beneficial to diabetes

“…Supplementation with antioxidants offers protection against oxidative stress and free radical damage. 32,33 PAE and PAM exhibited promising total antioxidant potential. PAE showed significant ABTS radical decolorisation potential (Fig.…”

“…Studies have shown that depletion of antioxidant status in patients with type 2 diabetes mellitus is responsible for the early onset of secondary complications. Supplementation with antioxidants offers protection against oxidative stress and free radical damage . PAE and PAM exhibited promising total antioxidant potential.…”

Antimicrobial activity of food‐compatible plant extracts and chitosan against naturally occurring micro‐organisms in tomato juice

“…For instance, antibacterial activity of aqueous, methanolic and ethyl acetate extracts of Acacia salicina Lindl. against Staphylococcus aureus and Salmonella serovars Enteritidis and Typhimurium has been reported 13. Also, aqueous and methanolic extracts of Schizandrae Fructus ( Schisandra chinensis (Turcz.)…”