Phytochemical and pharmacological study of the distillation extract from Salvia officinalis leaves

Vovk, G. V.; Myga, M. M.; Коshovyi, Oleh; Verkhovodova, Yu. V.; Kireev, I. V.

doi:10.24959/ubphj.16.10

Cited by 2 publications

(2 citation statements)

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“…Оптичну густину вимірювали на спектрофотометрі Thermo Evolution 60S (США) за відповідної довжини хвилі. Вміст суми гідрохінонпохідних визначали в перерахунку на арбутин за 455 нм після реакції з амінопіразолоном [21], суми похідних гідроксикоричних кислот визначали в перерахунку на хлорогенову кислоту за 327 нм [15,17], вміст суми флавоноїдів у перерахунку на рутин -за довжини хвилі 417 нм [16,18], вміст суми фенольних сполук у перерахунку на галову кислоту -за 270 нм [20,22]. Для статистичної достовірності досліди проводили не менше п'яти разів [21].…”

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Prospects of creating a new medicine based on biologically active substances of bearberry leaves for correction of the metabolic syndrome

Chaika¹,

Коshovyi²,

Mazen³

et al. 2021

Ukr. biopharm. j.

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Topicality. The metabolic syndrome is pathogenetically interrelated metabolic disorders in the condition of a sick person. A large set of factors is involved in its occurrence. Risk factors include genetic predisposition, overeating, insulin resistance, obesity, bad habits, hypodynamics, stress and unfavorable environmental conditions. First of all, defects of the lipid and carbohydrate metabolism provoke a cascade of genetic, metabolic, hormonal, nervous, inflammatory and other reactions and disorders in cells, tissues and organs, causing the metabolic syndrome and associated diseases, such as diabetes, kidney and gallstone disease, hypertension, platelet hyperaggregation, etc. Therefore, the rational use of synthetic and herbal medicines in the complex correction of these disorders can slow down the development of the metabolic syndrome. Aim. To develop the method for obtaining a dry modified extract from bearberry, study its chemical composition, hypoglycemic and hypolipidemic activity in order to determine the prospects of its use for the correction of the metabolic syndrome. Materials and methods. The study object was a dry extract of bearberry leaves modified with cysteine. HPLC and spectrophotometry were used to analyze the extract obtained. The hypoglycemic and hypolipidemic activity of dry extracts of bearberry was studied in rats with insulin resistance. Results and discussion. The method for obtaining a dry modified extract from bearberry leaves was developed by adding cysteine. Phenologlycoside (arbutin), 2 phenolic acids (gallic and ellagic), 6 flavonoids, 8 saponins were identified in the extract, and their quantitative content was determined. Hyperoside and catechin were dominant among flavonoids, and ursolic acid, uvaol, and lupeol prevailed among saponins. The content of the main groups of phenolic compounds was determined in the extract by spectrophotometry. The introduction of the dry extract from bearberry leaves modified with cysteine has a normalizing effect on metabolic disorders on the background of a high-fructose diet; therefore, it can be a promising agent for the correction of the metabolic syndrome. Conclusions. As a result of the research conducted, a new dry extract from bearberry leaves modified with cysteine has been created. The phytochemical composition, hypoglycemic and hypolipidemic activities of the extract have been studied, indicating the prospects for its use to correct the metabolic syndrome.

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Section: матеріали та методиunclassified

Prospects of creating a new medicine based on biologically active substances of bearberry leaves for correction of the metabolic syndrome

Chaika¹,

Коshovyi²,

Mazen³

et al. 2021

Ukr. biopharm. j.

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“…Увагу привертає шавлія лікарська, лікарська рослинна сировина (ЛРС) якої містить велику кількість борнеолу, камфори, каріофілену, цинеолу, елемену, гумулену, ледену, пінену і туйону [4,6,8,16,23,24,25,31].…”

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Relevance of research of the pharmacological properties of salvia (Salvia officinalis) (literature review)

Ye.V.¹

2022

Med. perspekt.

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Salvia officinalis (sage) attracts attention as it is widely cultivated on the territory of Ukraine. It is known that it has long been used in traditional medicine, as it contains large amounts of borneol, camphor, caryophyllene, cineole, ale, humulene, chilling, pinene and thujone. The purpose of this review is to collect and analyze information on the relevance of using the medicinal properties of raw Salvia officinalis (sage), since it reveals oncoprotective, antimutagenic, antioxidant, hepatoprotective, anti-inflammatory, antimicrobial, antifungal action, normalizes metabolic processes, and has successfully proven itself in the composition of cosmeceuticals. Taking into account the current COVID-19 pandemic situation in the world, as well as the anti-inflammatory, antimicrobial, antiviral properties of Salvia officinalis (sage), its positive effect on the normalization of the level of lipid peroxidation, antioxidant enzymes (superoxide dismutase and catalase), as well as a significant effect on reducing pulmonary fibrosis, dosage forms based on Salvia officinalis, can be used for prevention, comprehensive treatment and rehabilitation after a COVID-19 infection. The analysis of the pharmaceutical market showed that in Ukraine, medicines based on Salvia officinalis are used in the treatment of diseases of the upper respiratory tract, as well as in climacteric syndrome and psychoemotional stress, in the complex therapy of chronic diseases of the gastrointestinal tract and genitourinary system. The collected and systematized information indicates that medicinal plant Salvia officinalis (sage) can be used in a more diverse way. Therefore, we consider it expedient to further study the pharmacological properties of Salvia officinalis and develop a technology for the manufacture of new dosage forms for internal use based on it.

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Phytochemical and pharmacological study of the distillation extract from Salvia officinalis leaves

Cited by 2 publications

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Prospects of creating a new medicine based on biologically active substances of bearberry leaves for correction of the metabolic syndrome

Prospects of creating a new medicine based on biologically active substances of bearberry leaves for correction of the metabolic syndrome

Relevance of research of the pharmacological properties of salvia (Salvia officinalis) (literature review)

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