Phytochemical and Pharmacological Properties of the Genus Melodinus – A Review

Jiang, Jingjing; Zhang, Wudi; Chen, Ye‐Gao

doi:10.4314/tjpr.v14i12.25

Cited by 25 publications

(15 citation statements)

References 39 publications

(100 reference statements)

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“…research showed that about 66 alkaloids of different structures have been isolated from M. henryi so far [8,[12][13][14]19]. In this study, 15 monoterpenoid indole alkaloids were isolated and identified.…”

Section: Aggregationsmentioning

confidence: 82%

“…Furthermore, there is an urgent need for phytochemical investigation on bioactive ingredients of this plant to understand the chemical components of MHTA. Phytochemical research showed that about 66 alkaloids of different structures have been isolated from M. henryi so far [ 8 , 12 – 14 , 19 ]. In this study, 15 monoterpenoid indole alkaloids were isolated and identified.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the chemical constituents and contents of aspidosperma-type alkaloids may be related to the toxicity of MHTA. Besides, some quinoline and indole alkaloids isolated from Melodinus plants, such as 15-dihydroscandine, 15β-hydroxy-14,15-dihydroscandine, melaxillines A and B, melodinine T, scandine, 11-hydroxytabersonine, and O -methyl-Δ 14 -vincanol-3-one exhibited significant anti-inflammatory activity [ 17 , 28 , 44 , 45 ]. Among the isolates in this study, tabersonine ( 4 ) could attenuate LPS-induced acute lung injury and inhibited LPS-mediated macrophage activation in vitro [ 46 ], 11-hydroxytabersonine ( 5 ) showed inhibitory effect on NO production [ 17 ], tubotaiwine ( 9 ) showed good inhibitions on COX-1 and COX-2 in anti-inflammatory assay in vitro [ 47 ], and melaxilline A ( 14 ), scandine ( 12 ), and meloscandonine ( 15 ) significantly inhibited in release of β-glucuronidase [ 28 ], suggesting these compounds may be responsible for the anti-inflammatory effect of MHTA.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, 15 monoterpenoid indole alkaloids were isolated and identified. According to the structural characteristics, the compounds were classified as strychnos-type alkaloids (1-3), aspidosperma-type alkaloids (4)(5)(6)(7)(8), condylocarpan-type alkaloid (9), eburna-type alkaloids (10)(11), and quinoline-type alkaloids (12)(13)(14)(15). Previous reports on the cytotoxic activities of the compounds showed that aspidosperma-type alkaloids 4, 5, 6 and 8 had significant cytotoxic activities on human cancer cell lines, while other types of compounds have no obvious cytotoxic activity [13,19].…”

Section: Aggregationsmentioning

confidence: 99%

“…Plants of the genus Melodinus (Apocynaceae) are rich in terpenoid indole alkaloids (TIAs) and widely distributed in the tropical and sub-tropical regions [8]. Among them, M. henryi is a perennial vine mainly distributed in China, Thailand, and Burma [9] and has been used as a folk medicine for the treatment of infantile meningitis and fractures [9].…”

Section: Introductionmentioning

confidence: 99%

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Acute and Sub-Acute Toxicological Evaluations of Bioactive Alkaloidal Extract from Melodinus henryi and Their Main Chemical Constituents

Yang

Wang

Fan

et al. 2020

Nat. Prod. Bioprospect.

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Melodinus henryi is a good source of terpenoid indole alkaloids, and traditionally used as a folk medicine in the treatment of meningitis and fracture. In order to further exploit their potential uses, its anti-inflammatory and immunosuppressive activities, safety evaluations and chemical profiles have been illustrated. Compared to the crude methanol extract from M. henryi and its non-alkaloidal fraction, the total alkaloidal fraction (MHTA) had the strongest anti-inflammatory and immunosuppressive activities. In the acute oral toxicity assay, the half lethal dose (LD 50) of MHTA was more than 2000 mg/kg. The sub-acute toxicity assay for consecutive 28 days exhibited MHTA at a lower concentrations of less than 500 mg/kg might be regarded as safe, and might damage spleen, liver, kidney, and heart when the dose is higher than 1000 mg/kg. In addition, a phytochemical investigation on MHTA led to the isolation of 15 monoterpenoid indole alkaloids. Thus, in regard with the potent side effects of MHTA, it should be used with caution in the development of phytomedicine. Meilian Yang and Yudan Wang have contributed equally to this work.

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Section: Aggregationsmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Aggregationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Acute and Sub-Acute Toxicological Evaluations of Bioactive Alkaloidal Extract from Melodinus henryi and Their Main Chemical Constituents

Yang

Wang

Fan

et al. 2020

Nat. Prod. Bioprospect.

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Synthesis of Alkaloids and Compounds Containing the 3,4‐Benzomorphan Scaffold

Rodríguez,

Bonjoch,

Bradshaw

2023

Eur J Org Chem

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Several natural products bearing an embedded hexahydro‐ 2,6‐methano‐1‐benzazocine framework (3,4‐benzomorphan), a heterocyclic regioisomer of the 6,7‐benzomorphan substructure found in morphine alkaloids, have therapeutic potential for a variety of diseases. Biogenesis, biosynthetic approaches, and total syntheses of alkaloids or synthetic azapolycyclic compounds featuring the aforementioned azatricyclic ring system (i.e., a 3,4‐benzomorphan scaffold), are reviewed.

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