Phytochemical and Pharmacological Approaches of Traditional Alternate Cassia occidentalis L.

Ali, Mohammed Ashraf; Ansari, S. H.; Ahmad, Sayeed; Sanobar, Syeda; Hussain, Arshad; Khan, Shah Alam; Alam, Sarfaraz; Ali, Sajid; Ahmad, Faruque; Hakeem, Khalid Rehman

doi:10.1007/978-3-030-04408-4_15

Cited by 6 publications

(8 citation statements)

References 44 publications

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“…In traditional medicine, all parts of the plant are used [ 19 ]. The plant possesses antioxidant, nephroprotective and hepatoprotective activity, immunomodulatory activity, antidiabetic activity, analgesic and antipyretic activity, antianxiety, antidepressant and antimutagenic activity as well as antibacterial and antifungal activity [ 22 – 25 ].…”

Section: Introductionmentioning

confidence: 99%

Senna occidentalis (L.) Link root extract inhibits Plasmodium growth in vitro and in mice

Mogaka

Molu

Kagasi

et al. 2023

BMC Complement Med Ther

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Background Senna occidentalis (L.) Link has been used worldwide in traditional treatment of many diseases and conditions including snakebite. In Kenya, a decoction from the plant roots taken orally, is used as a cure for malaria. Several studies have demonstrated that extracts from the plant possess antiplasmodial activity, in vitro. However, the safety and curative potency of the plant root against established malaria infection is yet to be scientifically validated, in vivo. On the other hand, there are reports on variation in bioactivity of extracts obtained from this plant species, depending on the plant part used and place of origin among other factors. In this study, we demonstrated the antiplasmodial activity of Senna occidentalis roots extract in vitro, and in mice. Methods Methanol, ethyl acetate, chloroform, hexane and water extracts of S. occidentalis root were tested for in vitro antiplasmodial activity against Plasmodium falciparum, strain 3D7. Cytotoxicity of the most active solvent extracts was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and the curative potency in Plasmodium berghei infected mice evaluated by Rane’s test. Results All of the solvent extracts tested in this study inhibited the propagation of P. falciparum, strain 3D7, in vitro, with polar extracts being more active than non-polar ones. Methanolic extracts had the highest activity (IC50 = 1.76) while hexane extract displayed the lowest activity (IC50 = 18.47). At the tested concentrations, methanolic and aqueous extracts exhibited high selectivity index against P. falciparum strain 3D7 (SI > 10) in the cytotoxicity assay. Further, the extracts significantly suppressed the propagation of P. berghei parasites (P < 0.05) in vivo and increased the survival time of the infected mice (P < 0.0001). Conclusions Senna occidentalis (L.) Link root extract inhibits the propagation of malaria parasites in vitro and in BALB/c mice.

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Section: Introductionmentioning

confidence: 99%

Senna occidentalis (L.) Link root extract inhibits Plasmodium growth in vitro and in mice

Mogaka

Molu

Kagasi

et al. 2023

BMC Complement Med Ther

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“…Fever, stomach discomfort, anaemia, and overall weakness are among the many uses for the plant [20], [21]. Flower extract, for example, is one of various plant components that have been reported to have distinct therapeutic effects (toxic to Klebsiella pneumonia) [22], leaves (antimalarial, analgesic, and antipyretic action) [23], [24]. This work used a green synthesis approach to create silver nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles Biosynthesis, Structural Characterization, Antibacterial Action, and Antioxidant Potential

Tyagi

Rajput

Yadav³

et al. 2022

ECS Trans.

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The goal of this work is to address the green synthesis of silver nanoparticles (AgNPs) from Cassia occidentalis leaf aqueous extract. The AgNPs were studied using UV–visible spectroscopy, transmission electron microscopy, scanning electron microscopy, and X-ray diffraction. The spectra of AgNPs had a single strong peak at 435 nm, but the spectra of extract had two peaks at 230 and 250 nm, indicating the presence of polyphenols and phytochemicals in the solution, and the X-ray diffraction patterns showed that they were crystals. Obtained nanoparticles are round and oval in shape, according to TEM and SEM investigations, with diameters ranging from 6 to 30 nm. Pathogenic microorganisms such as E. coli and B. subtilis were used to investigate AgNPs antibacterial efficacy. As a consequence, it was discovered that green AgNPs exhibit significant antibacterial activity.

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“…It is also found in African countries like Nigeria and Ghana. It is an annual/perennial herb which grows up to 0.60-1.50 m in height and at altitudes of up to 1500 m (Ali et al, 2019;Kaur et al, 2014). Reported ethnomedicinal uses of S. occidentalis leaf show that it prevents leucorrhoea and also possesses febrifugal, purgative and diuretic properties.…”

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confidence: 99%

“…It is employed in the treatment of cough, rheumatism, jaundice and it is popular for its relief of many skin ailments (Vijayalakshmi et al, 2013). Phytoconstituents such as physcion, 4, 4, 5, 5-tetrahydroxy-2,2-dimethyl-1,1-bianthraquinone, helminthosporin, quercetin, questin, xanthorin, occidentalol-,1 occidentalol-II cassiaoccidentalins A, B and xanthorin have been reportedly isolated from the leaf (Ali et al, 2019;Yadav et al, 2009). Among the biological activities that have been reported for the plant are hypoglycemic, hepatoprotective, antiinflammatory, antimalarial, immunosuppressant, antiatherosclerogenic, hypolipidemic and antipyretic activities (Nde et al, 2022;Ali et al, 2019;Uzzi and Grillo, 2013;Yadav et al, 2009).…”

mentioning

confidence: 99%

“…Phytoconstituents such as physcion, 4, 4, 5, 5-tetrahydroxy-2,2-dimethyl-1,1-bianthraquinone, helminthosporin, quercetin, questin, xanthorin, occidentalol-,1 occidentalol-II cassiaoccidentalins A, B and xanthorin have been reportedly isolated from the leaf (Ali et al, 2019;Yadav et al, 2009). Among the biological activities that have been reported for the plant are hypoglycemic, hepatoprotective, antiinflammatory, antimalarial, immunosuppressant, antiatherosclerogenic, hypolipidemic and antipyretic activities (Nde et al, 2022;Ali et al, 2019;Uzzi and Grillo, 2013;Yadav et al, 2009). It is one of the plants which have aphrodisiac function and among the five categories of aphrodisiac, this plant with others like Cannabis sativa L. (Cannabaceae), Strychnos nux vomica L. (Loganiaceae) and Myristica fragrans Houtt.…”

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confidence: 99%

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Neutral Effect of Coffee Senna (Senna occidentalis (L.) Link Leguminosae) Leaf Ethanol Extract on Reproductive Parameters in Male Wistar Rats

Alade¹,

Ugwudike²,

Alade³

et al. 2022

jasem

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Many antimalarial remedies are known for reproductive toxicity in male. Also, several plants are known to have antifertility action in both sexes. The aim of this study is to evaluate the effect of ethanol extract of Senna occidentalis (L.) Link Leguminosae leaf (EESO) on male reproductive parameters such as sperm count, motility, morphology and the histology of testes in Wistar rats by employing standard procedures. The extract (50% ethanol) was orally administered to male Wistar rats daily, at 250, 500 and 1000 mg/kg with distilled water as control, for 20 days after which reproductive parameters were performed on the epididymal sperm and testes. The results show that all features were consistent with normal histology of the testes in the treated and untreated groups, the sperm count (SC), motility (SM) and morphology (MP) were also comparable with the control. The plant has been shown to be devoid of the traditional sperm toxicity associated with antimalarial agents.

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Phytochemical and Pharmacological Approaches of Traditional Alternate Cassia occidentalis L.

Cited by 6 publications

References 44 publications

Senna occidentalis (L.) Link root extract inhibits Plasmodium growth in vitro and in mice

Senna occidentalis (L.) Link root extract inhibits Plasmodium growth in vitro and in mice

Silver Nanoparticles Biosynthesis, Structural Characterization, Antibacterial Action, and Antioxidant Potential

Neutral Effect of Coffee Senna (Senna occidentalis (L.) Link Leguminosae) Leaf Ethanol Extract on Reproductive Parameters in Male Wistar Rats

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