Phytochemical and HPTLC Studies on Fruit Extracts of Momordica cymbalaria Fenzl, a Medicinally Important Plant

Shantakani, Srinivasulu; Y, Pallavi; Devi, Bollu Gayatri; Jyothi, H. K.

doi:10.15835/nsb939910

Cited by 4 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The highest phenolic content was observed in the methanol-n-butanol extract, followed by extracts C, A, D and B. This finding is consistent with reports by Srinivasulu et al, (2017) which 74.65 ± 0.04 GAE mg/g phenolic content were identified from methanol extract followed by ethyl acetate (62.16 ± 0.07 GAE mg/gm).…”

Section: Effect Of Solvent On the Phytoconstituentssupporting

confidence: 91%

Effect of extraction solvents on the phytochemical content and bioactivity of Momordica charantia Linn. fruits

Rahim¹,

Yaakob²,

Hisam³

et al. 2021

Mal. J. Fund. Appl. Sci.

View full text Add to dashboard Cite

Momordica charantia (M. charantia) is a herbaceous climber commonly found in Southeast Asia with therapeutic importance for various illnesses. This study focused on the effect of extraction solvents on saponins-containing compounds from M. charantia and their bioactivities. Different organic solvents including water, ethanol, ethyl acetate, a mixture of methanol-water and methanol-n-butanol were used in the extraction process. The total saponin content, total flavonoid and phenolic content for each extract were examined. In addition, the antioxidant capacity of these extracts were evaluated using both 1,1-diphenyl-2-picrylhydrazyl (DPPH) Free Radical Scavenging Activity and 2,2’-azino-bis-3- ethylbenzthiazoline-6-sulphonic acid (ABTS) assay. Furthermore, a-amylase and lipase inhibition assay were carried out using an in vitro model. The result showed that methanol-n-butanol extracts exhibited the highest total saponin, flavonoid, phenolic content, and ABTS antioxidant activity compared to the other extracts. The a-amylase inhibition assay revealed that water extract and methanol-n-butanol extract from M. charantia contained potent a-amylase inhibitor. On the other hand, the ethyl acetate extract was found to have the most antioxidant capacities based on DPPH radical scavenging assay. The ethyl acetate extract also exhibited the highest inhibition of lipase activities. In conclusion, the methanol-n-butanol solvent was found to be the most effective in extracting saponin from M. charantia. The M. charantia extracts showed inhibition of a-amylase and lipase activities which may suggest the therapeutic potential of M. charantia for obesity and diabetes.

show abstract

Section: Effect Of Solvent On the Phytoconstituentssupporting

confidence: 91%

Effect of extraction solvents on the phytochemical content and bioactivity of Momordica charantia Linn. fruits

Rahim¹,

Yaakob²,

Hisam³

et al. 2021

Mal. J. Fund. Appl. Sci.

View full text Add to dashboard Cite

show abstract

“…The methanolic extract tested showed a positive result for all bioactive compounds, including alkaloids, flavonoids, tannins, saponins, and phenols. Hence, this discovery of bioactive compounds can start a new drug discovery and development as the compounds are presented with significant major secondary metabolites (25). The previous study done by (26) also proves that alkaloids, steroids glycoside, saponins, and phenolic compounds that possess considerable biological importance are present in the ethanolic extract of M. charantia.…”

Section: Phytochemical Analysismentioning

confidence: 78%

Qualitative Phytochemical Screening and Antibacterial Properties of Momordica charantia Methanolic Extract Against Selected Bacterial Strains

Cheong¹,

Zakaria²,

Yusof³

2022

MJMHS

View full text Add to dashboard Cite

Introduction: The persistent development of bacterial resistance against currently available antibacterial drugs necessitates the search for new antimicrobial agents. The major part of this research is to overcome drug resistance in infectious agents by utilizing medicinal plants as the main natural source in the production of new pharmaceuticals. As 25-50% of contemporary medications are derived from plants, this sparked renewed interest in therapeutic plants. Due to the largely diverse phytochemical compounds found in crude extracts of medicinal plants, they could be used as an alternative source of antimicrobial agents. This study aims to screen the phytochemical compounds and evaluate the antibacterial effect of Momordica charantia fruit extract, obtained by maceration in 100% absolute methanol. Method: Disc diffusion and broth microdilution methods were performed to evaluate the inhibitory effect of M. charantia fruit extract on Staphylococcus aureus, Escherichia coli, and Salmonella typhimurium. Results: The phytochemical tests conducted revealed that the fruit extracts tested positive for alkaloids, phenols, tannins, flavonoids, and saponins. The methanolic extract of M. charantia fruit demonstrated antibacterial activity against S. aureus with a mean inhibition zone of (17mm±0.82), but not against E. coli or S. typhimurium. For S. aureus, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were 125mg/ml and 500mg/ml, respectively. Conclusion: Based on the findings, the current study offers insight into the therapeutic potential of M. charantia where the methanolic fruit extract of the fruit has been shown to have antimicrobial activity against S. aureus and has the potential to be exploited as an antimicrobial agent.

show abstract

Green and ecofriendly reduction of graphene oxide by amino acids obtained from M. cymbalaria and its qualitative and quantitative analysis by HPTLC technique

Ananthi,

Saral

2024

Biomass Conv. Bioref.

View full text Add to dashboard Cite

Phytochemical and HPTLC Studies on Fruit Extracts of Momordica cymbalaria Fenzl, a Medicinally Important Plant

Cited by 4 publications

References 15 publications

Effect of extraction solvents on the phytochemical content and bioactivity of Momordica charantia Linn. fruits

Effect of extraction solvents on the phytochemical content and bioactivity of Momordica charantia Linn. fruits

Qualitative Phytochemical Screening and Antibacterial Properties of Momordica charantia Methanolic Extract Against Selected Bacterial Strains

Green and ecofriendly reduction of graphene oxide by amino acids obtained from M. cymbalaria and its qualitative and quantitative analysis by HPTLC technique

Contact Info

Product

Resources

About