Phytochemical and Biological Study of<i>Slemmadenia minima</i>

Gupta, Mahabir P.; Álvarez, Diana Aurelia Balseca; Solís, Pablo N.; Löwel, Matthias; Achenbach, Hans

doi:10.1055/s-2006-960186

Cited by 3 publications

(6 citation statements)

References 2 publications

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“…Optical rotations, uv, and cd measurements were made in MeOH. Nmr spectra, if not otherwise stated, were recorded in CD3OD with TMS as the internal standard for 'H nmr at 400 MHz and for 1 'C nmr at 100 MHz on a Jeol GX 400 instrument. Ms were run by ei at 70 eV on a Finnigan 4500 instrument and high resolution measurements on a MAT 311.…”

Section: Experimental General Experimentalmentioning

confidence: 99%

“…

A novel betaine-type indole alkaloid, 16-e/>z-panarine [1], was isolated from Stemmadenia minima. Its structure was determined by spectral studies and chemical interconver-We recently reported the alkaloid screening of different parts of the Central American plant Stemmadenia minima A. Gentry (Apocynaceae) (1).

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mentioning

confidence: 99%

“…A novel betaine-type indole alkaloid, 16-e/>z-panarine [1], was isolated from Stemmadenia minima. Its structure was determined by spectral studies and chemical interconver-…”

mentioning

confidence: 99%

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16-epi-Panarine, a New Betaine-Type Alkaloid from Stemmadenia minima

Achenbach¹,

Löwel²,

Waibel³

et al. 1991

J. Nat. Prod.

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Section: Experimental General Experimentalmentioning

confidence: 99%

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confidence: 99%

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16-epi-Panarine, a New Betaine-Type Alkaloid from Stemmadenia minima

Achenbach¹,

Löwel²,

Waibel³

et al. 1991

J. Nat. Prod.

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“…Dimethylobovatine [4],-Amorphous compound, [ MHz) 0.89 (6H, dt,7=7.1 Hz, H3-18 and H3-18'), 1.14 (2H, m, Hs-15 and Hs-15'), 1.25 (2H, m, H-20 and H-20'), 1.60 (4H, m, H2-19 and H2-19'), 1.79(2H,m, HK-15 andHR-15'), 1.84(2H, m, Hr-17 and HR-17'), 2.45 (2H, m, Hs-17 and Hs-17'), 2.90 (4H, m, H2-3 and H2-3'), 3.07 (2H, m, Hr-6 and HR-6'), 3.23 (2H, m, HR-5 and HR-5'), 3.27 (2H, m, Hs-6 and Hs-6'), 3.40 (2H, m, Hs-5 and Hs-5'), 3.52 (2H, m, H-21 and H-21'), 3.65 (6H, s, 2 XCOOMe), 3.81 (6H,s, 2 X ArOMe), 6.91 and 6.96 (1H each, d,7=8.3 Hz, H-10 and H-10'), 7.40 (2H, br s, 2XNH), 7.42 and 7.51 (1H each, dj=8.3 Hz, H-9 and H-9')•…”

Section: Methodsmentioning

confidence: 99%

“…Proton-carbon chemical shift correlations for all the carbons directly bonded to protons could be established in an HMQC experiment (Table 2). 134.2 (C-13V149.4 (C-ll) 6.98 (H-10) 124.4 (C-8)/103.1 (C-12) 7.52 (H-9') 134.4 (C-l3')/l53.2 (C-ll') 6.91 (H-10') When compound 2 was methylated with CH2N2 in Et20, the monomethyl derivative 1 and the dimethyl derivative 4 were obtained, confirming chemically the structure of 1. Compound 4 has not been previously found in nature.…”

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confidence: 99%

Obovatine, a New Bisindole Alkaloid from Stemmadenia obovata

Valencia¹,

Madinaveitia²,

Bermejo³

et al. 1995

J. Nat. Prod.

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A new bisindole alkaloid, obovatine [1], has been isolated from the leaves of Stemmadenia obovata together with the known compounds, bis[. 11 -hydroxycoronaridin-12-yl] [2], 11 -hydroxycoronaridine [5], and voacristine [6]. The structure of 1 was established by spectroscopic analysis and chemical transformations.Stemmadenia obovata (Benth.) Woods.(Apocynaceae), is one of ten species (1-7) known to produce ibogaine-type indole alkaloids (8). This particular species has no place in the popular pharmacopeia, unlike, for instance, S. donnelsmithii, which is widely used in Central America to treat rheumatism, eye inflammation, and toothache (9). Alkaloids were first obtained from the bark, fruit and seeds ofS. obovata by Collera et al. in 1962 (2) and now a new bisindole alkaloid, obovatine [1}, has been isolated from the leaves of this species, together with the known alkaloids, bis[ 11 -hydroxycoronaridin-12yl] [2] (10), 11-hydroxycoronaridine [51 (11), and voacristine (19-hydroxyvoacangine) [6] (12).The CHClj extract of the leaves of S. obovata was subjected to a combination of Sephadex LH-20 and Si gel chromatography to afford four ibogaine-type indole alkaloids, 1, 2, 5, and 6. Compound 1 proved to be a new indole alkaloid dimer, obovatine.

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A Quarter Century of Pharmacognostic Research on Panamanian Flora: A Review

Caballero‐George¹,

Gupta²

2011

Planta Med

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Introduction !Medicinal plants remain an endless source of new drugs, new drug leads, and new chemical entities (NCEs) [1]. In developing countries, medicinal plants have been the most accessible source of medicaments and in rural areas, traditional medicine is part of the first line of treatment for common pathologies [2]. The geographical characteristics of the Isthmus of Panama are responsible for its highly diverse flora and fauna. This diversity promotes the use of plants in traditional medicine by the Amerindian groups and the rural population, which have limited access to modern drugs. Panama is a unique terrestrial bridge of great biological importance. Panamanian flora is one of the richest in the world with an estimate of 9893 different species of vascular plants, of which 1327 (13.4 %) are endemic [3]. There is a large number of nonvascular species but they have not been investigated fully. Panama has over 687 species of ferns and about 1000 species of orchids, of which 50 % are endemic. Epiphytes, lianas, and climbers are a major component of the Panamanian tropical forest. Mosses abound in moist cloud forests as well as other parts of the country. Panama is considered one of the botanical "hot spot" countries and occupies the fourth place in the world in number of vascular species [4]. The number of species per 10 000 km 2 ranks even much higher than in bigger countries like India, China, and the United States [5]. Evidence of the biomedical potential of herbal drugs used in Panamanian traditional medicine is continually being reported. Panamanian plants have been evaluated for their biological activities on a diverse range of disease targets. They have been studied inter alia as cytotoxic to cancer cell lines, antimalarial, antileishmanial, antimicrobial, antiviral, larvicidal, antioxidant, immunosupressive, acetylcholinesterase inhibitors, and antihypertensive agents [6][7][8][9][10]. Research on the highly diverse Panamanian flora proposes new economical and medicinal ventures attractive to the pharmaceutical industry. In the National Science Strategic Plan 2010-2014, a very high priority has been assigned to the study and utilization of Panamanian biodiversity as a source Supporting information available at

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Phytochemical and Biological Study ofSlemmadenia minima

Cited by 3 publications

References 2 publications

16-epi-Panarine, a New Betaine-Type Alkaloid from Stemmadenia minima

16-epi-Panarine, a New Betaine-Type Alkaloid from Stemmadenia minima

Obovatine, a New Bisindole Alkaloid from Stemmadenia obovata

A Quarter Century of Pharmacognostic Research on Panamanian Flora: A Review

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