Phytochemical and Biological Studies on Ziziphora bungeana

Radhakrishnan, S.; Zhaparkulova, Karlygash; Sakipova, Zuriyadda; Ibragimova, Liliya; Ross, Samir A.

doi:10.1007/s10600-018-2296-0

Cited by 6 publications

(6 citation statements)

References 9 publications

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“…and belongs to the genus Ziziphora L. in the Labiatae family. The plant is mainly distributed in Kazakhstan, China, Central Asia, and Mongolia, and is used to treat hypertension and heart diseases [ 1 ]. In China, it only grows in the Xinjiang Uygur Autonomous Region and has long been used as a folk medicine to treat diseases such as cardiopathy, hypertension, fever, headache, insomnia, and cardiopalmus [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…In China, it only grows in the Xinjiang Uygur Autonomous Region and has long been used as a folk medicine to treat diseases such as cardiopathy, hypertension, fever, headache, insomnia, and cardiopalmus [ 2 , 3 ]. The main active constituents of Z. bungeana are flavonoids and essential oils [ 1 – 6 ]. The essential oils of Z. bungeana have antioxidant and antimicrobial activities [ 1 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…The main active constituents of Z. bungeana are flavonoids and essential oils [ 1 – 6 ]. The essential oils of Z. bungeana have antioxidant and antimicrobial activities [ 1 , 4 ]. The flavonoids of Z. bungeana have significant protective functions for vascular endothelial cells [ 5 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Integrated metabolomic and transcriptomic profiling reveals the tissue-specific flavonoid compositions and their biosynthesis pathways in Ziziphora bungeana

Yang

Cheng

et al. 2020

Chin Med

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Background Ziziphora bungeana Juz. is a folk medicine from the Xinjiang Uygur Autonomous Region. The herb or the aerial parts of it have been used to medicinally treat cardiovascular diseases. Flavonoids are the main pharmacologically active ingredients in Z . bungeana . Identification of the tissue-specific distribution of flavonoids in Z . bungeana is crucial for effective and sustainable medicinal use of the plant. Furthermore, understanding of the biosynthesis pathways of these flavonoids in Z . bungeana is of great biological significance. Methods The flavonoids from different tissues of Z. bungeana were identified using liquid chromatography-tandem mass spectrometry (LC–MS/MS). The full-length transcriptome of Z. bungeana was determined using a strategy based on a combination of Illumina and PacBio sequencing techniques. The functions of differentially expressed unigenes were predicted using bioinformatics methods and further investigated by real-time quantitative PCR and phylogenetic relationship analysis. Results Among the 12 major flavonoid components identified from Z. bungeana extracts, linarin was the most abundant component. Nine flavonoids were identified as characteristic components of specific tissues. Transcriptome profiling and bioinformatic analysis revealed that 18 genes were putatively involved in flavonoid biosynthesis. The gene expression and phylogenetic analysis results indicated that ZbPALs , Zb4CL3 , ZbCHS1 , and ZbCHI1 may be involved in the biosynthesis of the main flavonoid intermediate. ZbFNSII , ZbANS , and ZbFLS may be involved in the biosynthesis of flavones, anthocyanins, and flavonols, respectively. A map of the biosynthesis pathways of the 12 major flavonoids in Z. bungeana is proposed. Conclusions The chemical constituent analysis revealed the compositions of 9 characteristic flavonoids in different tissues of Z. bungeana . Linarin can be hydrolysed into acacetin to exert a pharmaceutical role. Apigenin-7- O -rutinoside is hypothesised to be the precursor of linarin in Z. bungeana . There was greater content of linarin in the aerial parts of the plant than in the whole herb, which provides a theoretical basis for using the aerial parts of Z. bungeana for medicine. These results provide a valuable reference for further research on the flavonoid biosynthesis pathways of Z. bungeana ...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Integrated metabolomic and transcriptomic profiling reveals the tissue-specific flavonoid compositions and their biosynthesis pathways in Ziziphora bungeana

Yang

Cheng

et al. 2020

Chin Med

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“…However, this is the first report on essential oil composition from this plant. In continuation to our previous work on essential oil composition of Kazakhstan medicinal plants [6], we were interested to continue working on A. asiatica. Agrimoniin was first isolated in 1982 from roots of A. pilosa, a plant traditionally used in Japan and China as an antidiarrheal, haemostatic, and antiparasitic agent.…”

Section: Introductionmentioning

confidence: 99%

Isolation of Chemical Compounds and Essential Oil from Agrimonia asiatica Juz. and Their Antimicrobial and Antiplasmodial Activities

Kozykeyeva

Datkhayev

Radhakrishnan

et al. 2020

The Scientific World Journal

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Agrimonia asiatica is a perennial plant with deep green color and covered with soft hairs and has a slightly aromatic odor. This genus Agrimonia has been used in traditional medicines of China, Greece, and European countries. It was mainly used as a haemostatic, a tonic for asthenia, and an astringent for diarrhea. Agrimony is part of the division Magnoliophyta; class is represented by order Rosales, family Rosaceae, of the genus Agrimonia. Family Rosaceae—or pink eels—is one of the largest families of flowering plants, including about 100 genera and 3000 species. Rosaceae is common in almost all areas of the globe where flowering plants can grow, but most of them are concentrated in the temperate and subtropical zones of the Northern Hemisphere. Phytochemical investigation on ethanolic extract of A. asiatica led to isolation of four flavonoid derivatives (kaempferol-3-glycoside, quercetin-3-O-α-arabinofuranosyl-β-D-galactopyranoside, 3-O-kaempherol 2,3-di-O-acetyl-4-O-(cis-p-coumaroyl)-6-O-(trans-p-coumaroyl)-β-D-glucosopyranoside, and catechin) alongside of sucrose. All the extracts, fractions, and isolated compounds were tested for antimicrobial and antiplasmodial activities. We also studied the chemical composition of essential oil obtained from the aerial part of A. asiatica. The essential oil constituents from the aerial part of A. asiatica were obtained using a steam-distillation method in wild growing conditions in Kazakhstan. The essential oil extracted from the aerial part of the plant was analyzed by gas chromatography-mass spectroscopy and its major components amounting to 100% were found to be β-selinene (36.370%), α-panasinsene (21.720%), hexadecanoic acid (7.839%), and 1,2-nonadiene (6.199%). Neither the extract nor the isolated compounds showed antimicrobial and antiplasmodial activities.

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“…In this regard, the purpose of our activity was to develop the composition, technology and quality assessment of films with antibacterial and anti-inflammatory properties, thanks to the use of a CO 2 -extract of the plant Z. bungeanaJuz family Lamiaceaeas their basis [5]. Ziziphora phytochemicals include monoterpene essential oils, triterpenes, and phenolic substances belonging to flavonoids.…”

Section: Introductionmentioning

confidence: 99%

Development of the orodispersible films based on CO2 extract of Ziziphora bungeana with antimicrobial activity

Zhaparkulova¹,

Gani²,

Сакипова³

et al. 2020

Bull. of the Kar. Univ. "Chem". Ser.

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The present work was intended to develop the new drug in the form of film soluble in the oral cavity: development of its composition, production technology, the study of its antimicrobial activity. The relevance of the problem is caused by the absence of drugs in the form of films on the domestic pharmaceutical market. The optimal composition of films was selected by evaluating a number of physical, chemical and technological indicators of the obtained films. The article indicates the materials used to obtain the drugs in question, presents the technology for their preparation and quality determination methods: unit measurement methods and potentiometric determination of pH, tensiometric and conductometric methods, thin-layer and gas chromatography and others. Antimicrobial activity of the resulting films has been proven in vitro. Staphylococcus aureus ATCC 6538-p and Escherichia coli ATCC 8739 have been used as the test microorganisms in order to study them by disk diffusion method in agar. The introduction of СО2 extract of Z. bungeana from medicinal plant raw materials as active ingredients in medicinal films will expand the range of complex phytopreparations of the domestic pharmaceutical market for the treatment of inflammatory diseases of the oral mucosa.

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Phytochemical and Biological Studies on Ziziphora bungeana

Cited by 6 publications

References 9 publications

Integrated metabolomic and transcriptomic profiling reveals the tissue-specific flavonoid compositions and their biosynthesis pathways in Ziziphora bungeana

Integrated metabolomic and transcriptomic profiling reveals the tissue-specific flavonoid compositions and their biosynthesis pathways in Ziziphora bungeana

Isolation of Chemical Compounds and Essential Oil from Agrimonia asiatica Juz. and Their Antimicrobial and Antiplasmodial Activities

Development of the orodispersible films based on CO2 extract of Ziziphora bungeana with antimicrobial activity

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