Phytochemical and antioxidant studies of Laurera benguelensis growing in Thailand

Manojlović, N.; Vasiljević, Perica; Gritsanapan, Wandee; Supabphol, Roongtawan; Manojlovic, I.

doi:10.4067/s0716-97602010000200004

Cited by 46 publications

(27 citation statements)

References 29 publications

(18 reference statements)

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“…In fact, Xanthoria species were shown to contain various anthraquinone pigments, and especially parietin (Brodo et al 2001). Manojlovic et al (2010) investigated the anthraquinones content of lichen Laurera benguelensis and reported that the lichen extracts showed high anti-oxidant activity due to its metabolites including parietin. In accordance with this finding, Yim et al (1998) determined that the cellular protection afforded by the anthraquinonecontaining fraction of herbal extracts might be related to its ability to sustain the glutathione anti-oxidant status under the oxidative stress conditions.…”

Section: Discussionmentioning

confidence: 99%

Xanthoria elegans (Link) (lichen) extract counteracts DNA damage and oxidative stress of mitomycin C in human lymphocytes

2012

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Several lichen species have been used for medicinal purposes throughout the ages, and they are reported to be effective in the treatment of different disorders including ulcer and cancer. It is revealed that lichens may be easily accessible sources of natural drugs and possible food supplements after their safety evaluations. The main objective in this study was to evaluate the roles of aqueous extracts of Xanthoria elegans (at 25, 50 and 100 lg/ml) upon mitomycin C (MMC; at 10 -7 M) induced genotoxic and oxidative damages in cultured human lymphocytes. X. elegans were collected from the Erzurum and Artvin provinces (in Turkey) during August 2010. After the application of MMC and X. elegans extract (XEE), separate and together, human whole blood cultures were assessed by four genotoxicity end-points including chromosomal aberration, micronucleus, sister chromatid exchange (SCE) and 8-oxo-2-deoxyguanosine (8-OHdG) assays. In addition, biochemical parameters [total antioxidant capacity (TAC) and total oxidative stress (TOS)] were examined to determine oxidative effects. According to our results, the frequencies of cytogenetic endpoints and 8-OH-dG levels were significantly increased by MMC compared with controls in human peripheral lymphocytes. MMC caused oxidative stress by altering TAC and TOS levels. On the contrary, XEE led to increases of TAC level without changing TOS level. XEE had no genotoxic effect. Furthermore, our findings revealed that MMC induced increases in the mean frequencies of four genotoxic indices were diminished by XEE in dose dependent manner, indicating its protective role towards cells from MMC exerted injury. In conclusion, the results obtained in the present study indicate for the first time that XEE is a potential source of natural antigenotoxicants.

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Section: Discussionmentioning

confidence: 99%

Xanthoria elegans (Link) (lichen) extract counteracts DNA damage and oxidative stress of mitomycin C in human lymphocytes

2012

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“…Praveen Kumar et al (2010) determined the antioxidant activity of the extracts of the lichen Ramalina hossei and Ramalina conduplicans. Manojlović et al (2010a) explored the antioxidant properties of Laurera benguelensis. Kosanić et al (2012a, b) found that the lichens Umbilicaria crustulosa, U. cylindrica, U. polyphylla, Parmelia caperata, P. sulcata, and P. saxatilis have a strong antioxidant effect.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of in vitro antioxidant, antimicrobial, genotoxic and anticancer activities of lichen Cetraria islandica

et al. 2014

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In this study, the antioxidant, antimicrobial, genotoxic and anticancer activities of Cetraria islandica methanol extract were determined by using free radical and superoxide anion scavenging activity, reducing power, determination of total phenolic compounds and flavonoid contents, broth microdilution minimal inhibitory concentration against five bacterial and five fungal species, cytokinesis block micronucleus (MN) assay on peripheral blood lymphocytes (PBLs) and the microculture tetrazolium test on FemX (human melanoma) and LS174 (human colon carcinoma) cell lines. As a result of the study, we found that C. islandica methanol extract exhibited moderate free-radical-scavenging activity with IC 50 values 678.38 lg/ml. Moreover, the tested extract had effective reducing power and superoxide anion radical scavenging. The minimal inhibitory concentration values against the tested microorganisms ranged from 0.312 to 5 mg/ml. The extract increased MN frequency in a dose dependent manner, but it was significant in higher tested concentrations (50, 100 and 200 lg/ml). No significant differences were observed between NDI values in all treatments and untreated PBLs. In addition, the tested extract had strong anticancer activity towards both cell lines with IC 50 values of 22.68 and 33.74 lg/ml. It can be concluded that the tested extract exhibited a certain level of in vitro antioxidant, antimicrobial, genotoxic and anticancer activities.

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“…It has been shown that the biosynthesis of secalonic acid D (see Fig. 2 for the chemical structure) was dependent on the biosynthesis of the pigment emodin via the acetate-malonate pathway in a study conducted on the lichen Laurera benguelensis 41 . Diverse biological activities of secalonic acid D have been reported, such as a mycotoxin towards chicken and mice embryo, an inhibitor of various isozymes of protein kinase C and protein kinase A in murine secondary palate development 123 , as well as mouse and human cleft palatal inducing agent 124 .…”

Section: Current Industrial Applications Of Natural Hydroxyanthraquinmentioning

confidence: 99%

Natural hydroxyanthraquinoid pigments as potent food grade colorants: an overview

Caro

Anamale

Fouillaud

et al. 2012

Nat. Prod. Bioprospect.

140

109

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Natural pigments and colorants are widely used in the world in many industries such as textile dying, food processing or cosmetic manufacturing. Among the natural products of interest are various compounds belonging to carotenoids, anthocyanins, chlorophylls, melanins, betalains… The review emphasizes pigments with anthraquinoid skeleton and gives an overview on hydroxyanthraquinoids described in Nature, the first one ever published. Trends in consumption, production and regulation of natural food grade colorants are given, in the current global market. The second part focuses on the description of the chemical structures of the main anthraquinoid colouring compounds, their properties and their biosynthetic pathways. Main natural sources of such pigments are summarized, followed by discussion about toxicity and carcinogenicity observed in some cases. As a conclusion, current industrial applications of natural hydroxyanthraquinoids are described with two examples, carminic acid from an insect and Arpink red™ from a filamentous fungus.

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Phytochemical and antioxidant studies of Laurera benguelensis growing in Thailand

Cited by 46 publications

References 29 publications

Xanthoria elegans (Link) (lichen) extract counteracts DNA damage and oxidative stress of mitomycin C in human lymphocytes

Xanthoria elegans (Link) (lichen) extract counteracts DNA damage and oxidative stress of mitomycin C in human lymphocytes

Evaluation of in vitro antioxidant, antimicrobial, genotoxic and anticancer activities of lichen Cetraria islandica

Natural hydroxyanthraquinoid pigments as potent food grade colorants: an overview

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