Phytochemical and antioxidant characterization, cytogenotoxicity and antigenotoxicity of the fractions of the ethanolic extract of in <i>Poincianella bracteosa</i> (Tul.) L.P. Queiroz

Freire, Jamilson Dos Santos; Fernandes, Bianca Cristina Dos Santos; Silva, Julia Adelaide Cardeal da; Araujo, José Rafael da Silva; Almeida, Pedro Marcos de; Júnior, Joaquim Soares da Costa; Silva, Jurandy Nascimento da; Freitas, Samya Danielle Lima de; Martins, Francielle Alline

doi:10.1080/15287394.2020.1824136

Cited by 19 publications

(2 citation statements)

References 65 publications

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“…Plants have been characterized as an important source of pharmaceutical products with therapeutic or prophylactic properties which are associated with anti-inflammatory, antioxidant, antibacterial, antigenotoxic and antiproliferative activities of their bioactive compounds [ 1 , 2 , 3 , 4 ]. Due to their beneficial properties, their use for various therapeutic purposes has increased tremendously over the last decades worldwide.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and Genotoxicological Evaluation of Prickly Pear Peel Extracts

Dormousoglou

Efthimiou

Αντωνοπούλου

et al. 2023

Plants

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This study investigated the beneficial properties of prickly pear peel (PPP) extracts from Opuntia ficus-indica (L.) Mill. Extracts were obtained via the Soxhlet extraction method using methanol (P1), ethanol (P2) and ethanol-water (P3) as extraction solvents. Their total phenolic and flavonoid content (TPC and TFC, respectively) and their antioxidant activity (AA) were determined. The PPP extracts were characterized in detail using mass spectrometry techniques. Their cyto-genotoxic effect and antigenotoxic potential against mitomycin C were evaluated via the cytokinesis block micronucleus (CBMN) assay on human lymphocytes. Enhanced TPC, TFC and AA values were recorded for all the extracts. Moreover, P1 and P2 were cytotoxic only at the highest concentrations, whereas P3 was found to be cytotoxic in all cases. No significant micronucleus induction was observed in the tested extracts. The PPP extracts contain bioactive compounds such as flavonoids, carboxylic acids, alkaloids, fatty acids and minerals (mainly K, Si, Mg, Ca, P and Zn). The results showed that all three extracts exerted high antigenotoxic activity. Our findings confirm the beneficial and genoprotective properties of PPP extracts and further studies on the bioactive compounds of Opuntia ficus-indica (L.) Mill. are recommended, as it constitutes a promising plant in pharmaceutical applications.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and Genotoxicological Evaluation of Prickly Pear Peel Extracts

Dormousoglou

Efthimiou

Αντωνοπούλου

et al. 2023

Plants

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“…It is well known that plants have important chemical compounds and can be models for many clinically proven drugs or used directly to treat, cure, and prevent diseases as an old‐fashioned method of medicinal practice 7,8 . In addition, people living in rural areas use many plants for various purposes such as religious ceremonies, black magic, food, clothing, shelter, agriculture, agrochemicals, and narcotics 9 .…”

Section: Introductionmentioning

confidence: 99%

Cytoprotective, antimutagenic/antirecombinogenic and antibacterial properties of Lallemantia iberica extracts

et al. 2022

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BACKGROUND Plants have important chemical compounds to protect organisms from many mutagens but they may also have dangerous toxic substances that must be tested before use. Lallemantia iberica has been used by local people for treatment of some diseases but it was never tested for its cell protective and antimutagenic/antirecombinogenic properties. In this study, it was aimed to determine the cytoprotective, antimutagenic/antirecombinogenic, antibacterial, antioxidant and phenolic profile of L. iberica by MTS assay, micronucleus test/somatic mutation recombination test (SMART), disc diffusion method, ABTS/DPPH tests and liquid chromatography (LC), respectively. RESULTS MTS assay results showed that both of the extracts supported the normal growth of healthy human lymphocytes and there was no significant difference between extracts. Although there was no significant increase in micronucleus concentration (‰) of the cultures treated with ethanol or methanol extracts, methanol extract caused slightly lower micronucleus concentration (12.64 ± 3.65‰) than the ethanol extract (24.46 ± 4.50‰). SMART results showed that ethanol and methanol extracts prevented harmful mitotic recombination. Lallemantia iberica also showed antibacterial activity against all of the strains tested, and the largest inhibition zones were observed with Pseudomonas aeruginosa (17.9 mm) and Enterobacter aerogenes (13.8 mm). Methanol extracts showed better antioxidant activities (ABTS IC50: 104.07 μg mL−1, DPPH IC50: 58.8 μg mL−1) than ethanol extracts (ABTS IC50: 344.03 μg mL−1, DPPH IC50: 233.7 μg mL−1). According to the LC results, the most abundant phenolic compounds were rutin hydrate (1796.4 ± 62.9 mg kg−1) and p‐coumaric acid (228.1 ± 7.60 mg kg−1). CONCLUSION Lallemantia iberica extracts had cell‐protective, antimutagenic/antirecombinogenic, antibacterial and strong antioxidant characteristics in relation to their rich phenolic content. © 2022 Society of Chemical Industry.

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Metabolomic and antioxidant potential analyses of the rhizome and leaves of Podophyllum hexandrum Royle: A comparative account

Lone,

Shahnawaz,

Singh

et al. 2023

Biocatalysis and Agricultural Biotechnology

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Phytochemical and antioxidant characterization, cytogenotoxicity and antigenotoxicity of the fractions of the ethanolic extract of in Poincianella bracteosa (Tul.) L.P. Queiroz

Cited by 19 publications

References 65 publications

Phytochemical Analysis and Genotoxicological Evaluation of Prickly Pear Peel Extracts

Phytochemical Analysis and Genotoxicological Evaluation of Prickly Pear Peel Extracts

Cytoprotective, antimutagenic/antirecombinogenic and antibacterial properties of Lallemantia iberica extracts

Metabolomic and antioxidant potential analyses of the rhizome and leaves of Podophyllum hexandrum Royle: A comparative account

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