Phytochemical and Antimicrobial Investigation of Latex from <i>Euphorbia Abyssinica</i> Gmel

El-Fiky, Fathy K.; Asres, Kaleab; Gibbons, Simon; Hammoda, Hala M.; Badr, Jihan M.; Umer, Shemsu

doi:10.1177/1934578x0800300922

Cited by 10 publications

(16 citation statements)

References 29 publications

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“…Another plant secondary metabolite with antiviral activity is oleanolic acid [105]. It is reported from Syzygium aromaticum [9], Ocimum basilicum, Ocimum lamiifolium, Ocimum urticifolium, and Olea europea subsp cuspidate [11], Osyris quadripartite [91], Acokanthera schimperi [78], Dregea schimperi [88], Euphorbia abyssinica [89], and Phytolacca dodecandra [93]. Oleanolic acid has a binding affinity for SARS-CoV-2 M protease and Spike (S) glycoprotein [106].…”

Section: Medicinal Plants With Antiviral Active Componentsmentioning

confidence: 99%

Candidate Anti-COVID-19 Medicinal Plants from Ethiopia: A Review of Plants Traditionally Used to Treat Viral Diseases

Tegen

Dessie

Damtie

2021

Evidence-Based Complementary and Alternative Medicine

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Background. Emerging viral infections are among the major global public health concerns. The pandemic COVID-19 is a contagious respiratory and vascular disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are no medicines that can treat SARS-CoV-2 except the vaccines. Therefore, searching for plant-originated therapeutics for the treatment of COVID-19 is required. Consequently, reviewing medicinal plants used to treat different viral infections is mandatory. This review article aims to review the ethnobotanical knowledge of medicinal plants traditionally used to treat different viral diseases by the Ethiopian people and suggests those plants as candidates to fight COVID-19. Methods. Articles written in English were searched from online public databases using searching terms like “Traditional Medicine,” “Ethnobotanical study,” “Active components,” “Antiviral activities,” and “Ethiopia.” Ethnobotanical data were analyzed using the Excel statistical software program. Result. From the 46 articles reviewed, a total of 111 plant species were claimed to treat viral infections. Fifty-six (50.4%) of the plant species had reported to have antiviral active components that are promising to treat COVID-19. Lycorine, gingerol shogaol, resveratrol, rhoifolin, oleanolic acid, kaempferol, rosmarinic acid, almond oil, ursolic acid, hederagenin, nigellidine, α-hederin, apigenin, nobiletin, tangeretin, chalcone, hesperidin, epigallocatechin gallate, allicin, diallyl trisulfide, ajoene, aloenin, artemisinin, glucobrassicin, curcumin, piperine, flavonoids, anthraquinone, hydroxychloroquine, and jensenone were some of them. Conclusion. The Ethiopian traditional knowledge applies a lot of medicinal plants to treat different viral infections. Reports of the chemical components of many of them confirm that they can be promising to fight COVID-19.

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Section: Medicinal Plants With Antiviral Active Componentsmentioning

confidence: 99%

Candidate Anti-COVID-19 Medicinal Plants from Ethiopia: A Review of Plants Traditionally Used to Treat Viral Diseases

Tegen

Dessie

Damtie

2021

Evidence-Based Complementary and Alternative Medicine

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“…It is abundant in Ethiopia, Sudan, Nigeria, and Somalia. 5 Traditionally, it was used to treat intestinal worms, diarrhea, head fungal infections, external injuries, venereal diseases, and neck cancer. 6 − 8 Different E. abyssinica stem bark extracts are reported to have antifungal attributes.…”

Section: Introductionmentioning

confidence: 99%

“… 9 Similarly, antibacterial and antifungal properties of plant latex were reported. 5 The root extract showed antimalarial potential in mice against Plasmodium berghei infection. 10 In the treatment of skin diseases, an ointment made from plant latex showed antibacterial and antiparasitic properties.…”

Section: Introductionmentioning

confidence: 99%

A Network Pharmacology Analysis of Cytotoxic Triterpenes Isolated from Euphorbia abyssinica Latex Supported by Drug-likeness and ADMET Studies

et al. 2022

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Euphorbia plants have been identified as potential sources of antitumor lead compounds. The current study aimed to isolate and identify the main active constituents of Euphorbia abyssinica latex followed by a cytotoxic evaluation. A network pharmacology approach was employed to predict the underlying mechanism. Finally, drug-likeness and ADMET studies were conducted for active compounds. The phytochemical investigation of the latex of E. abyssinica resulted in the isolation of two triterpenes, 3-acetyloxy-(3α)-urs-12-en-28-oic methyl ester ( 1 ) and lup-20(29)-en-3α,23-diol ( 2 ). The dichloromethane extract displayed potent cytotoxic activity against the MCF7 cell line with an IC 50 value of 4.27 ± 0.12 μg/mL but weak activity against HepG2 and HeLa cell lines (IC 50 = 20.47 ± 1.17 and 26.73 ± 2.99 μg/mL, respectively) compared to doxorubicin. Compound 1 showed an encouraging cytotoxic effect against MCF7 with IC 50 = 4.20 ± 0.20 μg/mL, followed by compound 2 (IC 50 = 5.8 ± 0.35 μg/mL). The network analysis revealed that the two isolated compounds are linked to 68 targets of human nature, among which 51 genes are linked to breast carcinomas and 5 targets (AR, CYP19A1, EGFR, PGR, and PTGS2) might be the top therapeutic targets of isolated compounds on breast cancer. Furthermore, the gene-enrichment analysis revealed that E. abyssinica could play a role in the treatment of breast cancer by striking 51 potential targets via mainly three signaling pathways: P13K–AKT, Wnt, and VEGF. Therefore, isolated triterpenes could be considered effective antitumor agents for breast cancer by elucidating their candidate target to alleviate breast cancer and related signaling pathways of the targets.

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“…abyssinica J.F. Gmel, commonly called desert candle, is a succulent monoecious geophyte, shrub, or tree that grow up to 9 m high [13]. It is widespread across most of Africa, the Arabian Peninsula, and in Southern Asia from Pakistan to Malaysia, Indonesia, and Papua New Guinea [14].…”

Section: Introductionmentioning

confidence: 99%

“…Its latex was reported to yield ingenol esters and lathyrane derivatives as minor components besides euphol, euphorbol, lupeol, oleanolic acid, β-sitosterol, and β-sitosterol-3-O-glucoside [13,16]. It has also been reported to contain rubber, waxes, and resins as major constituents, in addition to 8(R)-hydroxy-dec-3(E)en-oic acid, showing significant anti-fungal activity against Aspergillus flavus, Aspergillus niger, and Candida albicans [13]. Furthermore, E. abyssinica has exhibited cytotoxic activity against Caco2 (IC 50 11.3 µg/mL) [17].…”

Section: Introductionmentioning

confidence: 99%

Digalloyl Glycoside: A Potential Inhibitor of Trypanosomal PFK from Euphorbia abyssinica J.F. Gmel

El‐Hawary

Mohammed

Lithy

et al. 2022

Plants

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Human African trypanosomiasis is an endemic infectious disease caused by Trypanosoma brucei via the bite of tsetse-fly. Most of the drugs used for the treatment, e.g., Suramin, have shown several problems, including the high level of toxicity. Accordingly, the discovery of anti-trypanosomal drugs from natural sources has become an urgent requirement. In our previous study on the anti-trypanosomal potential of Euphorbia species, Euphorbia abyssinica displayed significant anti-trypanosomal activity. Therefore, a phytochemical investigation of the methanolic extract of E. abyssinica was carried out. Twelve compounds, including two triterpenes (1, 2); one sterol-glucoside (4); three ellagic acid derivatives (3, 9, 11); three gallic acid derivatives (5, 6, 10); and three flavonoids (7, 8, 12), were isolated. The structures of isolated compounds were determined through different spectroscopic techniques. Compound (10) was obtained for the first time from genus Euphorbia while all other compounds except compound (4), were firstly reported in E. abyssinica. Consequently, an in silico study was used to estimate the anti-trypanosomal activity of the isolated compounds. Several compounds displayed interesting activity where 1,6-di-O-galloyl-d-glucose (10) appeared as the most potent inhibitor of trypanosomal phosphofructokinase (PFK). Moreover, molecular dynamics (MD) simulations and ADMET calculations were performed for 1,6-di-O-galloyl-d-glucose. In conclusion, 1,6-di-O-galloyl-d-glucose revealed high binding free energy as well as desirable molecular dynamics and pharmacokinetic properties; therefore, it could be suggested for further in vitro and in vivo studies for trypanosomiasis.

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Phytochemical and Antimicrobial Investigation of Latex from Euphorbia Abyssinica Gmel

Cited by 10 publications

References 29 publications

Candidate Anti-COVID-19 Medicinal Plants from Ethiopia: A Review of Plants Traditionally Used to Treat Viral Diseases

Candidate Anti-COVID-19 Medicinal Plants from Ethiopia: A Review of Plants Traditionally Used to Treat Viral Diseases

A Network Pharmacology Analysis of Cytotoxic Triterpenes Isolated from Euphorbia abyssinica Latex Supported by Drug-likeness and ADMET Studies

Digalloyl Glycoside: A Potential Inhibitor of Trypanosomal PFK from Euphorbia abyssinica J.F. Gmel

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