Phytochemical and Anti-Microbial Screening of Crude Extracts of Natal Fig (FicusNatalensisKraus)

Sheyin, F.T; Ndukwe, G. I.; Iyun, Ogunkemi Risikat Agbeke; Anyam, J.V.; Habila, JD

doi:10.4314/jasem.v22i9.16

Cited by 3 publications

(3 citation statements)

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“…A total of 14 studies about the in vitro antibacterial activity of medicinal plants from Sub-Saharan Africa against Campylobacter spp. were found [23][24][25][26][27][28][29][30][31][32][33][34][35][36]. e majority of studies were from Nigeria (5 studies), South Africa (4), and Guinea-Bissau (3).…”

Section: Database Search Resultsmentioning

confidence: 99%

“…Nine studies tested the antimicrobial activity for Campylobacter spp. through the MIC [23,24,26,[29][30][31][33][34][35], while five studies tested only through disk diffusion method [25,27,28,32,36]. Table 1 provides a summary of the studied plant extracts, plant parts, isolated compounds, diameter of inhibition, MIC, and MBC of the tested plants.…”

Section: Results Of the In Vitromentioning

confidence: 99%

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A Systematic Review of In Vitro Activity of Medicinal Plants from Sub‐Saharan Africa against Campylobacter spp.

Hlashwayo

Barbosa

Langa

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Introduction. Campylobacter spp. are zoonotic bacteria that cause gastroenteritis in humans and may cause extraintestinal infections such as Guillain-Barré syndrome, reactive arthritis, and bacteremia. Resistance to antibiotics is an increasing concern in the Sub-Saharan Africa; thus, search for alternatives such as plant-based active ingredients is important in order to develop new drugs. Objectives. To present a systematic review of in vitro and in vivo studies of the antibacterial activity of medicinal plants from Sub-Saharan Africa against Campylobacter spp. Methodology. Studies published until March 2020 on medicinal plants used against Campylobacter spp. from each country of Sub-Saharan Africa were searched on PubMed, Science Direct, AJOL, and Google Scholar. Articles were selected based on the existence of information regarding in vitro and in vivo activity of medicinal plants against Campylobacter spp. Results. A total of 47 medicinal plants belonging to 28 families were studied for in vitro activity against Campylobacter spp. No plant was studied in vivo. Plants from Fabaceae family were the most commonly studied. The plants with the strongest antimicrobial activities were Cryptolepis sanguinolenta and Terminalia macroptera. The root extracts from these plants were effective, and both had a minimal inhibitory concentration (MIC) of 25 μg/ml. Seven pure compounds were isolated and analyzed for activity against Campylobacter spp. The compound cryptolepine from C. sanguinolenta was the most effective with MIC values ranging between 6.25 and 25 μg/ml. Conclusion. Several native plants from the Sub-Saharan Africa region were studied for in vitro activity against Campylobacter spp. Some plants seemed very effective against the bacteria. Chemical compounds from three plants have been isolated and analyzed, but further studies are needed in order to produce new and effective drugs.

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Section: Database Search Resultsmentioning

confidence: 99%

Section: Results Of the In Vitromentioning

confidence: 99%

A Systematic Review of In Vitro Activity of Medicinal Plants from Sub‐Saharan Africa against Campylobacter spp.

Hlashwayo

Barbosa

Langa

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…It was reported that alkaloids, terpenes, saponins, tannins, flavonoids, steroids and glycosides found in abundance in F. natalensis plant. These secondary metabolites has powerful zones of inhibition against a few chosen human infections with antibacterial activity (Sheyin et al, 2018). F. natalensis plant material is a potent source of antibacterial and antioxidant compounds.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

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Inflammation is immune response of body against foreign toxic substances. Chronic inflammation is associated with diabetes, heart diseases, arthritis and cancer. The present study aims to investigate anti-inflammatory potential of plant Ficus natalensis subspecies leprieurii. Various extracts of leaves of F. natalensis were investigated for bioactive phytochemicals and screened using in vitro activities of anti-inflammatory. In vivo study of anti-inflammatory potential was also conducted by using method of carrageenan induced paw edema. This plant showed potential in vitro protein denaturation assay of anti-inflammatory activity. In vivo assay revealed that n-hexane extract exhibited the maximum percentage inhibition of paw volume (83.49%) as compared to standard drug used. GC-MS analysis of nhexane extract exhibited tentative identification of bioactive phytochemicals which were further evaluated for their activity by using molecular docking. The results suggested that gamma tocopherol has the highest binding affinity with BSA. The results concluded that F. natalensis has medicinal importance and promising anti-inflammatory potential.

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Syntheses and determination of activities of some metal(II) complexes with derivatives of a novel vanillin–tryptophan Schiff base ligand

Abubakar,

Shallangwa,

Ibrahim

2024

J.Umm Al-Qura Univ. Appll. Sci.

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In this research, a novel L-tryptophan-vanillin Schiff base and three complexes were synthesised, characterization, and their biological activities were also determined. The physicochemical parameters of the compounds investigated revealed that, Schiff base ligand (SL) melting point = 84–85 °C, Schiff base ligand–Fe2+ complex = 245–246 °C, Schiff base ligand–Co2+complex = 271–272 °C, and Schiff base ligand–Ni2+complex > 350 °C. Molar conductivities was found to be 10,300, 5000, 17,300, and 52,900 Sm2 mol−1 for the Schiff base and the complexes, respectively. It indicates that the complexes are non-electrolytic in nature. The magnetic susceptibilities of the complexes were found to be higher than the spin-only values due to unpaired electrons (Fe2+ complex = 5.73 BM, Co2+ complex = 4.52 BM, and Ni2+ complex = 3.46 BM), suggesting octahedral geometries. Electronic absorption (max) for Fe2+ = 480, Co2+ = 520 nm, while Ni2+ shows two bands at 480 and 570 nm, which signifies the n → π* and π → π* transitions, respectively. Their crystallinity index was also assessed using the PXRD and it revealed that complexes are purely crystalline. Antimicrobial test results revealed that Co2+ and Fe2+ complexes have excellent activities against gram-negative bacteria (E. coli, F. Shigella, and S. Typhi). They are all effective against MRSA, K. Pneumoniae., and S. Pneumoniae, as well as A. niger and C. albicans. Therefore, based on the findings from the study, it was concluded that the Schiff base is a bidentate ligand, and octahedral geometries and paramagnetic were suggested for the complexes.

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Phytochemical and Anti-Microbial Screening of Crude Extracts of Natal Fig (FicusNatalensisKraus)

Cited by 3 publications

References 4 publications

A Systematic Review of In Vitro Activity of Medicinal Plants from Sub‐Saharan Africa against Campylobacter spp.

A Systematic Review of In Vitro Activity of Medicinal Plants from Sub‐Saharan Africa against Campylobacter spp.

Untitled

Syntheses and determination of activities of some metal(II) complexes with derivatives of a novel vanillin–tryptophan Schiff base ligand

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