Phytochemical Analysis Radical Scavenging Activity of the Extracts of Costus picatus Linn Coccinia indica W&amp; A, two Ethnic Medicinal Plants used in the Treatment of Diabetes mellitus

Ajithabai, M. D.; S, Sreedevi N.; Jayakumar, G.; Nair, Mangalam S.; Deepa, P; Rani, Seema

doi:10.5530/ax.2011.1.12

Cited by 7 publications

(2 citation statements)

References 10 publications

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“…Apart from the novel gibberic acid diterpene ipomone (1), other known compounds viz. behenic acid (2), 21 docosanol (3, behenyl alcohol), 22 ester of ferulic acid with linear chain fatty alcohol, i.e., tetracosyl ferulate (4), 23 stigmasterol (5), 24 β-sitosterol (6), 25 7,3′,5′-tri-O-methyltricetin (7), 26 and apigenin (8) 27 were identified by comparing the observed NMR spectra with the reported spectroscopic data (Supporting Information). C-4a).…”

Section: Resultsmentioning

confidence: 99%

Identification and Evaluation of Apoptosis-Inducing Activity of Ipomone from Ipomoea nil: A Novel, Unusual Bicyclo-[3.2.1] Octanone Containing Gibberic Acid Diterpenoid

et al. 2021

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Ipomone (1), a novel diterpenoid along with seven known compounds (2–8), was isolated for the first time from the acidified hydroalcoholic extract of Ipomoea nil seeds. The structures of the isolated compounds were elucidated via comprehensive NMR spectroscopic data. The absolute configuration of 1 was ascertained through NOESY, NMR, and ECD analyses. Compound 1 was found to contain an unusual bicyclo-[3.2.1] octanone, which appeared first time in any natural product that might be an artifact resulting from the acid-catalyzed 1,2 alkyl shift/rearrangement. The novel compound was screened for cytotoxic activity against a panel of 12 human cancer cell lines and exhibited weak cytotoxicity with IC50 values in the range of 34–86 μM (except for HEK-293 cells). Microscopic studies revealed that compound 1 induced apoptosis and autophagy in A549 cells. To further explore the signaling pathway involved, immunoblot analysis was performed that confirmed inhibition of apoptotic proteins PARP-1 and caspase-3 expression and upregulation of LC3B expression by compound 1. The compound was further subjected to molecular docking studies to evaluate its binding affinity with p110α, PARP-1, and caspase-3 proteins.

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Section: Resultsmentioning

confidence: 99%

Identification and Evaluation of Apoptosis-Inducing Activity of Ipomone from Ipomoea nil: A Novel, Unusual Bicyclo-[3.2.1] Octanone Containing Gibberic Acid Diterpenoid

et al. 2021

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“…Compound 8 showed the molecular formula of C 30 H 52 O 3, and, based on the data and comparison of the spectral values with the literature, it was elucidated as 3β, 24β, and 25-trihydroxycycloartane [27]. The 1 H NMR peaks at δ H 1.16 (H-26), 1.22 (H-27), 0.89 (H-28), 0.96 (H-18, H-29), and 0.80 (H-30) revealed six tertiary methyl groups and the peak at δ H 0.88 (H-21), a secondary methyl group.…”

Section: Structure Identification Of Compounds 1-9mentioning

confidence: 90%

Phytochemical Study of Euphorbia turcomanica Boiss.

et al. 2022

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The attraction to the Euphorbia genus, with its remarkable diversity in species, is due to its variety of chemical compositions. Euphorbia turcomanica is one of the species of the spurge family growing wildly in Iran. This research aims to investigate the presence of secondary metabolites, specially terpenoid compounds, in terms of structural determination. Samples of E. tucomanica were finely powdered and macerated with acetone/dichloromethane 2:1. Repeated column chromatography using silica gel, MPLC, and HPLC methods followed by the analysis of data obtained from spectroscopic means was carried out to purify and identify the terpenoid constituents. The chemical structures of nine known terpenoids were determined for the first time from E. turcomanica during this study. Loliolide (1), a monoterpene, and eight steroids and triterpenes, including simiarenol (2), isomultiflorenol (3), cycloart-25-ene-3β,24-diol (4), β-sitosterol (5), cycloart-23-ene-3β,25-diol (6), 3α, 11α-dihydroxyurs-12-ene (7), 3β, 24β, 25-trihydroxycycloartane (8), and 7α-hydroxystigmasterol (9) were isolated and identified. E. tucomanica, with a rich terpenoid profile, can be one of the valuable and economic sources providing compounds for drug development.

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