Phytochemical analysis of &lt;i&gt;Cyrtanthus obliquus&lt;/i&gt; bulbs from the informal street market of Kwazulu-Natal, South Africa

Mahlangeni, Nomfundo; Moodley, Roshila; Jonnalagaddaa, SB

doi:10.4314/ajtcam.v12i5.5

Cited by 4 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this regard, four homoisoflavanones (40)(41)(42)(43) were described from a CH 3 OH extract of the 'Knysna lily' Cyrtanthus obliquus (L.f.) Aiton [70]. Measurements made via the FRAP assay showed all four compounds to have antioxidant potential [70]. Further analysis with the DPPH free radical scavenging reagent revealed that the 3-benzylidenechromanones (40,41) were inactive, while the 3-benzylchromanones (42,43) This article is protected by copyright.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…By contrast, galanthamine (5) administered peritoneally at 2 mg/kg/day was seen to reverse all of the deleterious effects brought about by the carcinogen DMH [69]. There has also been interest in the contributions of non-alkaloid principles towards the antioxidant effects of the Amaryllidaceae [70]. In this regard, four homoisoflavanones (40)(41)(42)(43) were described from a CH 3 OH extract of the 'Knysna lily' Cyrtanthus obliquus (L.f.) Aiton [70].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…There has also been interest in the contributions of non-alkaloid principles towards the antioxidant effects of the Amaryllidaceae [70]. In this regard, four homoisoflavanones (40)(41)(42)(43) were described from a CH 3 OH extract of the 'Knysna lily' Cyrtanthus obliquus (L.f.) Aiton [70]. Measurements made via the FRAP assay showed all four compounds to have antioxidant potential [70].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

See 2 more Smart Citations

Anti-inflammatory Principles of the Plant Family Amaryllidaceae

Nair,

van Staden

2024

Planta Med

View full text Add to dashboard Cite

There is considerable interest in the utilization of plants against inflammation. Over 50 species of the plant family Amaryllidaceae are known for such usage in traditional medicine. This review was undertaken to identify the chemical principles responsible for these anti-inflammatory effects. It describes the findings from in vitro, in vivo and in silico studies as well as the probes made on the mechanisms of action. The literature search returned over 600 hits, of which around 130 were chosen for their relevance to the text. Over 140 compounds have thus far been screened for anti-inflammatory effects. These were mostly isoquinoline alkaloids, but also included other classes of secondary metabolites such as chromones, flavonoids and triterpenoids. In vitro studies were carried out in mononuclear cells such as lymphocytes, monocytes, neutrophils and macrophages, against which no serious side effects were observed. The constituents were also effective against inflammation induced by physical and chemical stimuli in a variety of murine test subjects. Chief among the compounds were the isoquinoline alkaloids lycorine and narciclasine, which displayed potent effects against pain, swelling, asthma and arthritis amongst others. From a mechanistic perspective several of the compounds were shown to mediate in inflammatory pathways, notably via the modulation of both pro-inflammatory (such as NF-κB, TNF-α and IL-1) and anti-inflammatory (such as IL-10 and TGF-β) factors. Useful insights also emerged from active-site docking studies of some of the compounds. The Amaryllidaceae affords a rich and diverse platform for the discovery of potential anti-inflammatory drugs.

show abstract

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

See 1 more Smart Citation

Anti-inflammatory Principles of the Plant Family Amaryllidaceae

Nair,

van Staden

2024

Planta Med

View full text Add to dashboard Cite

show abstract

“…Species of Cyrtanthus have been identified as reservoirs for a host of chemical compounds. In a study performed by Mahlangeni et al, four homoisoflavanones, namely 5,7-dihydroxy-6-methoxy-3-(4′-methoxybenzyl)chroman-4-one, 5,7-dihydroxy-6-methoxy-3-(4′hydroxybenzyl)chroman-4-one and two 5,7-dihydroxy-6-methoxy-3-(4′-methoxybenzylidene)chroman-4-one, 5,7-dihydroxy-3-(4′hydroxybenzylidene)-chroman-4-one were isolated from the hexane, methanol and dichloromethane extracts of Cyrtanthus obliquus [ 338 ]. The bulbs of C. obliquus extracted with ethanol also revealed the presence of novel alkaloid obliquine, as well as 1α-hydroxygalanthamine, 3-epimacronine, narcissidine, tazettine and trisphaeridine [ 339 ].…”

Section: The Genus Cyrtanthusmentioning

confidence: 99%

“…dihydroxy-6-methoxy-3-(4′-methoxybenzyl)chroman-4-one and 5,7-dihydroxy-6-methoxy-3-(4′-hydroxybenzyl)chroman-4-one isolated from the fresh bulbs of C. obliquus have been shown to possess significant antioxidant activity with an IC50 of 371.54 and 288.40 µg/mL, respectively[338].…”

mentioning

confidence: 99%

The Phytochemistry and Pharmacology of Tulbaghia, Allium, Crinum and Cyrtanthus: ‘Talented’ Taxa from the Amaryllidaceae

et al. 2022

View full text Add to dashboard Cite

Amaryllidaceae is a significant source of bioactive phytochemicals with a strong propensity to develop new drugs. The genera Allium, Tulbaghia, Cyrtanthus and Crinum biosynthesize novel alkaloids and other phytochemicals with traditional and pharmacological uses. Amaryllidaceae biomolecules exhibit multiple pharmacological activities such as antioxidant, antimicrobial, and immunomodulatory effects. Traditionally, natural products from Amaryllidaceae are utilized to treat non-communicable and infectious human diseases. Galanthamine, a drug from this family, is clinically relevant in treating the neurocognitive disorder, Alzheimer’s disease, which underscores the importance of the Amaryllidaceae alkaloids. Although Amaryllidaceae provide a plethora of biologically active compounds, there is tardiness in their development into clinically pliable medicines. Other genera, including Cyrtanthus and Tulbaghia, have received little attention as potential sources of promising drug candidates. Given the reciprocal relationship of the increasing burden of human diseases and limited availability of medicinal therapies, more rapid drug discovery and development are desirable. To expedite clinically relevant drug development, we present here evidence on bioactive compounds from the genera Allium, Tulgbaghia, Cyrtanthus and Crinum and describe their traditional and pharmacological applications.

show abstract

Chemical and biological studies of the South African Amaryllidaceae genera Crinum, Ammocharis, Amaryllis, Cyrtanthus and Brunsvigia

Nair

Staden

2021

South African Journal of Botany

View full text Add to dashboard Cite

Phytochemical analysis of <i>Cyrtanthus obliquus</i> bulbs from the informal street market of Kwazulu-Natal, South Africa

Cited by 4 publications

References 9 publications

Anti-inflammatory Principles of the Plant Family Amaryllidaceae

Anti-inflammatory Principles of the Plant Family Amaryllidaceae

The Phytochemistry and Pharmacology of Tulbaghia, Allium, Crinum and Cyrtanthus: ‘Talented’ Taxa from the Amaryllidaceae

Chemical and biological studies of the South African Amaryllidaceae genera Crinum, Ammocharis, Amaryllis, Cyrtanthus and Brunsvigia

Contact Info

Product

Resources

About