Phytochemical analysis of <i>Brugmansia suaveolens</i> Bercht. &amp; J. Presl and its therapeutic potential for topical use

Costa, Sandro Pinheiro da; Schuenck-Rodrigues, Raphaela Aparecida; Cardoso, Verônica da Silva; Valverde, Simone Sacramento; Vermelho, Alane Beatriz; Ricci, Esther Lopes

doi:10.1080/14786419.2022.2147930

Cited by 2 publications

(5 citation statements)

References 9 publications

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“…These substances have numerous applications, such as food additives, flavors, and industrially important products such as the development of new drugs [ 20 ]. Some of the natural products derived from plants include drugs such as morphine, codeine, cocaine, pilocarpine, and steroids such as diosgenin, digoxin, and digitoxin [ 8 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

“…The results showed that this monoterpenoid increased the secretion of IFN-γ, an immunological marker, and of IL-2 from peripheral blood mononuclear cells. They therefore observed an increase in the number of cell deaths in the A549 and MCF7 cell lines and showed an increase in ROS production and mitochondrial membrane disruption leading to apoptosis [ 8 , 80 ].…”

Section: Resultsmentioning

confidence: 99%

“…The antibacterial activity of methanolic extracts from B. suaveolens stem, leaves, and flowers was evaluated by means of the disk diffusion test. The result showed that extracts from the stem of the plant exerted mild antibacterial activity, while extracts from the leaves and flowers had no antibacterial activity [ 8 , 108 ].…”

Section: Resultsmentioning

confidence: 99%

“…Popularly, its dried flowers and leaves are used to treat strong coughs and bronchitis by inhaling its vapor. In the form of juice and/or ointment, it is applied to burns, abrasions, inflammation, hemorrhoids, arthritis, and rheumatism on the affected areas to relieve the pain generated by this trauma [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…and J. Presl is still a little-reported species regarding its biological effects, which enable the elucidation of substances of natural origin, stimulating the discovery of new products with different applications. This lack of comprehensive reports enables unprecedented studies using substances of natural origin, stimulating the discovery of new products with different applications [ 4 , 8 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Potential of Bioactive Compounds from Brugmansia suaveolens Bercht. & J. Presl

et al. 2023

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Brugmansia suaveolens Bercht. & J. Presl has been widely used due to the presence of different bioactive compounds. This review summarizes the latest advances and perspectives of the B. suaveolens plant species; it is a systematic literature review on aspects of botany, traditional uses, phytochemistry, pharmacology, and toxicology as therapeutic potential. In addition, 120 compounds are described, including alkaloids, flavonoids, terpenoids, steroids, amino acids, aromatics, and aliphatics. As for the therapeutic potential, it is described in extracts and compounds in the antitumor, anti-inflammatory, antioxidant, antimicrobial, antispasmodic, anticoagulant, and analgesic aspects, as well as the effects on the central nervous system. The toxicity of the genus stands out, especially the potential for organ toxicity. Therefore, this review evidenced the knowledge related to the traditional use based on the scientific research of Brugmansia suaveolens, highlighting an overview of bioactive compounds and biological and toxicological activities in order to provide a scientific basis for future studies on the value of this species for the development of new natural products.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Therapeutic Potential of Bioactive Compounds from Brugmansia suaveolens Bercht. & J. Presl

et al. 2023

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Bioactive profiling of Rumex vesicarius L. from the Hail region of Saudi Arabia: a study on its phytochemical and elemental analysis, antibiofilm, antibacterial, antioxidant properties, and molecular docking analysis

Sulieman,

Abdallah,

Alanazi

et al. 2024

Front. Microbiol.

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BackgroundRumex vesicarius is a wild leafy plant belonging to the family Polygonaceae, renowned for its therapeutic benefits. The genus Rumex comprises approximately 150 species distributed globally.ObjectiveThe study aimed to investigate the biological activities of R. vesicarius using in vitro and in silico methods.MethodsRumex vesicarius was collected from the mountains in Hail and extracted with methanol. The phytochemical composition was qualitatively determined using colorimetric detection methods. Additional analyses included elemental analysis, in silico docking, antioxidant, antibacterial, and anti-biofilm properties.ResultsThe extract contained various classes of phytochemicals, including flavonoids, phenolics, tannins, terpenes, and saponins. Sixteen constituents were identified through molecular docking, revealing inhibition against the filamentous temperature-sensitive protein Z (FtsZ), a crucial factor in bacterial cell division. Six compounds exhibited low binding scores ranging from −8.3 to −5.0 kcal/mol, indicating efficient interaction at the active site. Elemental analysis identified 15 elements, with potassium being the most abundant, followed by calcium, aluminum, silicon, iron, phosphorus, sulfur, magnesium, titanium, strontium, zinc, manganese, bromine, and chromium. Antioxidant analysis revealed significant properties at lower concentrations compared to ascorbic acid, butylated hydroxytoluene, and β-carotene. Antibacterial analysis demonstrated inhibitory effects on Bacillus subtilis MTCC121 and Pseudomonas aeruginosa MTCC 741, with inhibition zones of 13.67 ± 1.0 mm and 11.50 ± 1.0 mm, respectively. The MIC and MBC values ranged from 250 to 500 μg/mL. R. vesicarius also exhibited anti-biofilm activity.ConclusionWild-grown R. vesicarius from the mountains of Hail is rich in bioactive phytochemicals and essential minerals, exhibiting notable antioxidant and antibacterial properties.

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Phytochemical analysis of Brugmansia suaveolens Bercht. & J. Presl and its therapeutic potential for topical use

Cited by 2 publications

References 9 publications

Therapeutic Potential of Bioactive Compounds from Brugmansia suaveolens Bercht. & J. Presl

Therapeutic Potential of Bioactive Compounds from Brugmansia suaveolens Bercht. & J. Presl

Bioactive profiling of Rumex vesicarius L. from the Hail region of Saudi Arabia: a study on its phytochemical and elemental analysis, antibiofilm, antibacterial, antioxidant properties, and molecular docking analysis

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