Phytochemical Analysis, Antioxidant Activities In Vitro and In Vivo, and Theoretical Calculation of Different Extracts of Euphorbia fischeriana

Abstract

Euphorbia fischeriana has a long-standing history of use in traditional medicine for the treatment of tuberculosis diseases. However, the plant’s therapeutic potential extends beyond this specific ailment. The present study aimed to investigate the antioxidant properties of Euphorbia fischeriana and lay the groundwork for further research on its potential therapeutic applications. Phytochemical tests were performed on the plant, and 11 types of phytochemicals were identified. Ultraviolet–visible spectrophotometry was used to evaluate the active components and antioxidant properties of eight different solvent extracts, ultimately selecting acetone extract for further research. UHPLC-ESI-Q-TOF-MS identified 43 compounds in the acetone extract, and chemical calculations were used to isolate those with high content and antioxidant activity. Three stability experiments confirmed the extract’s stability, while cell viability and oral acute toxicity studies demonstrated its relatively low toxicity. In rats, the acetone extract showed significant protective effects against D-galactosamine-induced liver damage through histopathological examination and biochemical analysis. These results suggest that Euphorbia fischeriana’s acetone extract has potential in treating diseases related to oxidative imbalances. Therefore, this study highlights the plant’s potential therapeutic applications while providing insight into its antioxidant properties.

Euphorbia royleana Boiss Derived Silver Nanoparticles and Their Applications as a Nanotherapeutic Agent to Control Microbial and Oxidative Stress-Originated Diseases

“…The scavenging potential might be attributed to the synergic effect of both the elemental silver and phytochemicals present in LER and the dopping surface of AgNPs [28,29]. These findings align with previous research that has reported the DPPH [2,[30][31][32] scavenging potential of Euphorbia species and AgNPs coated with plant constituents. The AgNPs' significant antibacterial activity is owed to their affinity for cell membrane surface proteins, which disrupts cell permeability.…”

Actinidia arguta (Sieb. et Zucc.) Planch. ex Miq.: A Review of Phytochemistry and Pharmacology

“…Through the use of HPLC-MS technology, three phenolic compounds were identified in the roots: planchols A and B (54 and 55) and isotachioside (56) [18]. From the leaves of A. arguta, researchers isolated 11 phenolic compounds, namely, phydroxybenzoic acid (57); vanillic acid (58); protocatechuic acid (59); isovanillic acid (60); hydroxytyrosol (61) [29]; caffeoylthreonic acid (62); salvianic acid A (63) [30]; maysedilactones A, B, and D (64-66) [31]; and rhodioloside (73) [21]. Additionally, 10 phenolic compounds were identified in the fruit, including argutinosides J-L (67-69) [32], vanillic acid-4-O-β-D-glucopyranoside (70), 1-O-feruloyl-β-D-glucopyranoside (71), ferulic acid-4-O-β-D-glucopyranoside (72), 5-O-caffeoyl quinic acid methyl ester (74), 5-O-caffeoyl quinic acid butyl ester (75), 5-O-feruloyl quinic acid methyl ester (76), and 5-O-coumaroyl quinic acid methyl ester (77) [21].…”

“…However, there is growing evidence suggesting that synthetic antioxidants can result in liver damage and even cancer [58]. Consequently, the search for natural antioxidants from plants has gained prominence in recent years [59][60][61][62].…”

Antioxidant and Anti-Inflammatory Activity of the Ethanolic Extract of Euphorbia Hirta Leaf Extract: An In Vitro and In Silico Study

“…The Euphorbia hirta plant, abundant in various phytochemicals such as flavonoids, phenolic compounds, and terpenoids, has exhibited potential bioactivity in earlier studies. [ 3 4 ] However, a comprehensive investigation into the antioxidant and anti-inflammatory properties of its ethanolic leaf extract is warranted. This study aims to bridge this knowledge gap by conducting in vitro assays to evaluate the extract’s antioxidant capacity and its ability to mitigate inflammatory responses.…”