Phytochemical Analysis and in vitro Antibacterial Activities of Seagrass Enhalus acoroides against Staphylococcus aureus

Setyoningrum, Desy; Yamindago, Ade; S, Syarifah Hikmah J.; Maftuch, Maftuch

doi:10.21776/ub.rjls.2020.007.02.2

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…Antibacterial activity can be caused by components of secondary metabolites, namely phenolic compounds in the form of flavonoids and tannins. Flavonoids and tannins are bactericidal but not sporicidal (Setyoningrum et al, 2021) . Phenolic compounds interact with bacterial cell wall components, which can cause changes in the cell wall's permeability, then cause cell coagulation, which can also lead to the inhibition of bacterial intracellular enzymes (Aljadi and Yusoff, 2003) .…”

Section: Capsule Evaluation Test Resultsmentioning

confidence: 99%

Formulation and Evaluation of Antibacterial and Anti-Inflammatory Capsules Containing Phyllanthus emblica L. Fruit Nanoparticles

Masfria,

Sumaiyah,

Syahputra

et al. 2023

Sci. Technol. Indones

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Phyllanthus emblica fruit has diuretic, antibacterial, hepatoprotective, antitumor, hypocholesterolemic, antioxidant, and antiulcerogenic activities making it possible as a traditional medicine in capsule form. Capsule preparations have the advantage of covering the unpleasant taste and smell of medicinal ingredients, easy to swallow, so they are practical to use. This study aimed to formulate Phyllanthus emblica fruit nanoparticles in capsules and to test the antibacterial activity against Streptococcus mutans and Pseudomonas aeruginosa and anti-inflammatory activity by observing denaturation inhibition in vitro. The method used to manufacture Phyllanthus emblica fruit simplicia nanoparticles was used using a High Energy Ball mill grinding machine. Capsule formulation was carried out with various doses of nanoparticles (100, 150, and 200 mg). Evaluation includes weight uniformity and disintegration time. Test of its antibacterial activity against Streptococcus mutans and Pseudomonas aeruginosa and its anti inflammatory activity in vitro. The study found that all formulas could be made into capsules that met the evaluation test requirements. The results of the evaluation of disintegration time ranged from 6.17-11.33 minutes. For the evaluation results of weight uniformity, it was found that weight deviations in columns A1 and A2 were in the range between 0.9% to 2.8% and 0.9 to 1.3%. The study reports on the antibacterial activity of Phyllanthus emblica fruit nanoparticle capsules (PFNP) against Streptococcus mutans and Pseudomonas aeruginosa. The results indicate that PFNP exhibits a dose-dependent antibacterial effect, with inhibition zone diameters of 10.83 mm, 11.6 mm, and 12.63 mm observed at 100 mg, 150 mg, and 200 mg, respectively, against Streptococcus mutans. Similarly, PFNP demonstrated a dose-dependent antibacterial effect against Pseudomonas aeruginosa, with inhibition zone diameters of 10.7 mm, 11.4 mm, and 12.1 mm observed at doses of 100 mg, 150 mg, and 200 mg, respectively. PFNP capsules showed inhibition results with a value of 5.63%, 6.13%, and 6.80%. It was concluded that Phyllanthus emblica fruit nanoparticles (Phyllanthus emblica L.) could be formulated in capsule dosage forms with doses of 100 mg, 150 mg, and 200 mg; has antibacterial activity against Streptococcus mutans and Pseudomonas aeruginosa, and has no anti-inflammatory activity.

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Section: Capsule Evaluation Test Resultsmentioning

confidence: 99%

Formulation and Evaluation of Antibacterial and Anti-Inflammatory Capsules Containing Phyllanthus emblica L. Fruit Nanoparticles

Masfria,

Sumaiyah,

Syahputra

et al. 2023

Sci. Technol. Indones

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Alveolar performance of mice (Mus musculus) exposure to cigarette smoke after-treatment of ethanol extract of seagrass (Enhalus acoroides)

Sitania

Kakisina

Nindatu

et al. 2023

The 7th International Conference on Basic Sciences 2021 (Icbs 2021)

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Overview of bioactivity studies on marine natural products

Zamani

Rahman

Rosada

et al. 2021

IOP Conf. Ser.: Earth Environ. Sci.

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Marine natural products are sourced from marine biodiversity as natural raw materials for various commercial products. This study aims to review natural products of marine organisms and gap analysis for future research or challenges. A total of 109 references from 24 countries were collected. The analysis was carried out quantitatively and qualitatively. The bioactive compounds produced wereantioxidants, antibacterial, anticancer, antimicrobial, anti-fouling, antifungal, and anti-tumoral substances. Some marine organisms that can store chemical compounds through secondary metabolite processes are mangroves, seagrasses, macroalgae, microalgae, soft corals, molluscs, echinoderms, gastropods, cnidarians, sponges, fungi, and bacteria. Most of the papers only discuss the identification stage of the active compound, and some focus on product development. There are very few studies on prospects of commercialization and mass production. The problem to achieve mass production is due to the lack of interdisciplinary research collaboration. Future research challenges need to develop a transdisciplinary approach to study bioprospection research from upstream to downstream, starting from the potential identification of bioactive ingredients, product development, the availability of raw materials for mass production as well as commercialization and marketing.

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Phytochemical Analysis and in vitro Antibacterial Activities of Seagrass Enhalus acoroides against Staphylococcus aureus

Cited by 4 publications

References 13 publications

Formulation and Evaluation of Antibacterial and Anti-Inflammatory Capsules Containing Phyllanthus emblica L. Fruit Nanoparticles

Formulation and Evaluation of Antibacterial and Anti-Inflammatory Capsules Containing Phyllanthus emblica L. Fruit Nanoparticles

Alveolar performance of mice (Mus musculus) exposure to cigarette smoke after-treatment of ethanol extract of seagrass (Enhalus acoroides)

Overview of bioactivity studies on marine natural products

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